RHAG

Rh-associated glycoprotein, also known as RHAG, is a human gene.cite web | title = Entrez Gene: RHAG Rh-associated glycoprotein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6005| accessdate = ] RHAG has also recently been designated CD241 (cluster of differentiation 241).

PBB_Summary
section_title =
summary_text = The Rh blood group antigens (MIM 111700) are associated with human erythrocyte membrane proteins of approximately 30 kD, the so-called Rh30 polypeptides. Heterogeneously glycosylated membrane proteins of 50 and 45 kD, the Rh50 glycoproteins, are coprecipitated with the Rh30 polypeptides on immunoprecipitation with anti-Rh-specific mono- and polyclonal antibodies. The Rh antigens appear to exist as a multisubunit complex of CD47 (MIM 601028), LW (MIM 111250), glycophorin B (MIM 111740), and play a critical role in the Rh50 glycoprotein. [supplied by OMIM] cite web | title = Entrez Gene: RHAG Rh-associated glycoprotein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6005| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bakouh N, Benjelloun F, Cherif-Zahar B, Planelles G |title=The challenge of understanding ammonium homeostasis and the role of the Rh glycoproteins. |journal=Transfusion clinique et biologique : journal de la Société française de transfusion sanguine |volume=13 |issue= 1-2 |pages= 139–46 |year= 2006 |pmid= 16564724 |doi= 10.1016/j.tracli.2006.02.008
*cite journal | author=Ripoche P, Goossens D, Devuyst O, "et al." |title=Role of RhAG and AQP1 in NH3 and CO2 gas transport in red cell ghosts: a stopped-flow analysis. |journal=Transfusion clinique et biologique : journal de la Société française de transfusion sanguine |volume=13 |issue= 1-2 |pages= 117–22 |year= 2006 |pmid= 16574458 |doi= 10.1016/j.tracli.2006.03.004
*cite journal | author=Ridgwell K, Spurr NK, Laguda B, "et al." |title=Isolation of cDNA clones for a 50 kDa glycoprotein of the human erythrocyte membrane associated with Rh (rhesus) blood-group antigen expression. |journal=Biochem. J. |volume=287 ( Pt 1) |issue= |pages= 223–8 |year= 1992 |pmid= 1417776 |doi=
*cite journal | author=Avent ND, Ridgwell K, Mawby WJ, "et al." |title=Protein-sequence studies on Rh-related polypeptides suggest the presence of at least two groups of proteins which associate in the human red-cell membrane. |journal=Biochem. J. |volume=256 |issue= 3 |pages= 1043–6 |year= 1989 |pmid= 3146980 |doi=
*cite journal | author=Cherif-Zahar B, Raynal V, Gane P, "et al." |title=Candidate gene acting as a suppressor of the RH locus in most cases of Rh-deficiency. |journal=Nat. Genet. |volume=12 |issue= 2 |pages= 168–73 |year= 1996 |pmid= 8563755 |doi= 10.1038/ng0296-168
*cite journal | author=Huang CH |title=The human Rh50 glycoprotein gene. Structural organization and associated splicing defect resulting in Rh(null) disease. |journal=J. Biol. Chem. |volume=273 |issue= 4 |pages= 2207–13 |year= 1998 |pmid= 9442063 |doi=
*cite journal | author=Hyland CA, Chérif-Zahar B, Cowley N, "et al." |title=A novel single missense mutation identified along the RH50 gene in a composite heterozygous Rhnull blood donor of the regulator type. |journal=Blood |volume=91 |issue= 4 |pages= 1458–63 |year= 1998 |pmid= 9454778 |doi=
*cite journal | author=Iwamoto S, Omi T, Yamasaki M, "et al." |title=Identification of 5' flanking sequence of RH50 gene and the core region for erythroid-specific expression. |journal=Biochem. Biophys. Res. Commun. |volume=243 |issue= 1 |pages= 233–40 |year= 1998 |pmid= 9473510 |doi= 10.1006/bbrc.1997.8023
*cite journal | author=Matassi G, Chérif-Zahar B, Raynal V, "et al." |title=Organization of the human RH50A gene (RHAG) and evolution of base composition of the RH gene family. |journal=Genomics |volume=47 |issue= 2 |pages= 286–93 |year= 1998 |pmid= 9479501 |doi= 10.1006/geno.1997.5112
*cite journal | author=Huang CH, Liu Z, Cheng G, Chen Y |title=Rh50 glycoprotein gene and rhnull disease: a silent splice donor is trans to a Gly279-->Glu missense mutation in the conserved transmembrane segment. |journal=Blood |volume=92 |issue= 5 |pages= 1776–84 |year= 1998 |pmid= 9716608 |doi=
*cite journal | author=Chérif-Zahar B, Matassi G, Raynal V, "et al." |title=Rh-deficiency of the regulator type caused by splicing mutations in the human RH50 gene. |journal=Blood |volume=92 |issue= 7 |pages= 2535–40 |year= 1998 |pmid= 9746795 |doi=
*cite journal | author=Huang C, Cheng GJ, Reid ME, Chen Y |title=Rhmod syndrome: a family study of the translation-initiator mutation in the Rh50 glycoprotein gene. |journal=Am. J. Hum. Genet. |volume=64 |issue= 1 |pages= 108–17 |year= 1999 |pmid= 9915949 |doi=
*cite journal | author=Huang CH, Cheng G, Liu Z, "et al." |title=Molecular basis for Rh(null) syndrome: identification of three new missense mutations in the Rh50 glycoprotein gene. |journal=Am. J. Hematol. |volume=62 |issue= 1 |pages= 25–32 |year= 1999 |pmid= 10467273 |doi=
*cite journal | author=Iwamoto S, Suganuma H, Kamesaki T, "et al." |title=Cloning and characterization of erythroid-specific DNase I-hypersensitive site in human rhesus-associated glycoprotein gene. |journal=J. Biol. Chem. |volume=275 |issue= 35 |pages= 27324–31 |year= 2000 |pmid= 10862620 |doi= 10.1074/jbc.M003297200
*cite journal | author=Marini AM, Matassi G, Raynal V, "et al." |title=The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast. |journal=Nat. Genet. |volume=26 |issue= 3 |pages= 341–4 |year= 2000 |pmid= 11062476 |doi= 10.1038/81656
*cite journal | author=Westhoff CM, Ferreri-Jacobia M, Mak DO, Foskett JK |title=Identification of the erythrocyte Rh blood group glycoprotein as a mammalian ammonium transporter. |journal=J. Biol. Chem. |volume=277 |issue= 15 |pages= 12499–502 |year= 2002 |pmid= 11861637 |doi= 10.1074/jbc.C200060200
*cite journal | author=Mouro-Chanteloup I, D'Ambrosio AM, Gane P, "et al." |title=Cell-surface expression of RhD blood group polypeptide is posttranscriptionally regulated by the RhAG glycoprotein. |journal=Blood |volume=100 |issue= 3 |pages= 1038–47 |year= 2002 |pmid= 12130520 |doi=
*cite journal | author=Chen BS, Xu ZX, Xu X, "et al." |title=RhCG is downregulated in oesophageal squamous cell carcinomas, but expressed in multiple squamous epithelia. |journal=Eur. J. Cancer |volume=38 |issue= 14 |pages= 1927–36 |year= 2002 |pmid= 12204676 |doi=
*cite journal | author=Dahl KN, Westhoff CM, Discher DE |title=Fractional attachment of CD47 (IAP) to the erythrocyte cytoskeleton and visual colocalization with Rh protein complexes. |journal=Blood |volume=101 |issue= 3 |pages= 1194–9 |year= 2003 |pmid= 12393442 |doi= 10.1182/blood-2002-04-1187
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

External links

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