Leukemia inhibitory factor receptor

LIFR also known as CD118 (Cluster of Differentiation 118), is a subunit of a receptor for leukemia inhibitory factor.

PBB_Summary
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summary_text = The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, gp130. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin.cite web | title = Entrez Gene: LIFR leukemia inhibitory factor receptor alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3977| accessdate = ]

ee also

* Cluster of differentiation

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Tomida M |title=Structural and functional studies on the leukemia inhibitory factor receptor (LIF-R): gene and soluble form of LIF-R, and cytoplasmic domain of LIF-R required for differentiation and growth arrest of myeloid leukemic cells. |journal=Leuk. Lymphoma |volume=37 |issue= 5-6 |pages= 517–25 |year= 2003 |pmid= 11042511 |doi=
*cite journal | author=Lass A, Weiser W, Munafo A, Loumaye E |title=Leukemia inhibitory factor in human reproduction. |journal=Fertil. Steril. |volume=76 |issue= 6 |pages= 1091–6 |year= 2002 |pmid= 11730732 |doi=
*cite journal | author=Gearing DP, Bruce AG |title=Oncostatin M binds the high-affinity leukemia inhibitory factor receptor. |journal=New Biol. |volume=4 |issue= 1 |pages= 61–5 |year= 1992 |pmid= 1536831 |doi=
*cite journal | author=Gearing DP, Comeau MR, Friend DJ, "et al." |title=The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor. |journal=Science |volume=255 |issue= 5050 |pages= 1434–7 |year= 1992 |pmid= 1542794 |doi=
*cite journal | author=Gearing DP, Thut CJ, VandeBos T, "et al." |title=Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. |journal=EMBO J. |volume=10 |issue= 10 |pages= 2839–48 |year= 1991 |pmid= 1915266 |doi=
*cite journal | author=Boulton TG, Stahl N, Yancopoulos GD |title=Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors. |journal=J. Biol. Chem. |volume=269 |issue= 15 |pages= 11648–55 |year= 1994 |pmid= 7512571 |doi=
*cite journal | author=Schiemann WP, Graves LM, Baumann H, "et al." |title=Phosphorylation of the human leukemia inhibitory factor (LIF) receptor by mitogen-activated protein kinase and the regulation of LIF receptor function by heterologous receptor activation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 12 |pages= 5361–5 |year= 1995 |pmid= 7777512 |doi=
*cite journal | author=Gearing DP, Druck T, Huebner K, "et al." |title=The leukemia inhibitory factor receptor (LIFR) gene is located within a cluster of cytokine receptor loci on mouse chromosome 15 and human chromosome 5p12-p13. |journal=Genomics |volume=18 |issue= 1 |pages= 148–50 |year= 1994 |pmid= 8276403 |doi= 10.1006/geno.1993.1441
*cite journal | author=Sharkey AM, Dellow K, Blayney M, "et al." |title=Stage-specific expression of cytokine and receptor messenger ribonucleic acids in human preimplantation embryos. |journal=Biol. Reprod. |volume=53 |issue= 4 |pages= 974–81 |year= 1996 |pmid= 8547494 |doi=
*cite journal | author=Kojima K, Kanzaki H, Iwai M, "et al." |title=Expression of leukaemia inhibitory factor (LIF) receptor in human placenta: a possible role for LIF in the growth and differentiation of trophoblasts. |journal=Hum. Reprod. |volume=10 |issue= 7 |pages= 1907–11 |year= 1996 |pmid= 8583009 |doi=
*cite journal | author=Tomida M, Gotoh O |title=Structure of the gene encoding the human differentiation-stimulating factor/leukemia inhibitory factor receptor. |journal=J. Biochem. |volume=120 |issue= 1 |pages= 201–5 |year= 1997 |pmid= 8864865 |doi=
*cite journal | author=Wang Z, Melmed S |title=Identification of an upstream enhancer within a functional promoter of the human leukemia inhibitory factor receptor gene and its alternative promoter usage. |journal=J. Biol. Chem. |volume=272 |issue= 44 |pages= 27957–65 |year= 1997 |pmid= 9346946 |doi=
*cite journal | author=Tanaka M, Hara T, Copeland NG, "et al." |title=Reconstitution of the functional mouse oncostatin M (OSM) receptor: molecular cloning of the mouse OSM receptor beta subunit. |journal=Blood |volume=93 |issue= 3 |pages= 804–15 |year= 1999 |pmid= 9920829 |doi=
*cite journal | author=Knight DA, Lydell CP, Zhou D, "et al." |title=Leukemia inhibitory factor (LIF) and LIF receptor in human lung. Distribution and regulation of LIF release. |journal=Am. J. Respir. Cell Mol. Biol. |volume=20 |issue= 4 |pages= 834–41 |year= 1999 |pmid= 10101017 |doi=
*cite journal | author=Kakizawa T, Miyamoto T, Ichikawa K, "et al." |title=Functional interaction between Oct-1 and retinoid X receptor. |journal=J. Biol. Chem. |volume=274 |issue= 27 |pages= 19103–8 |year= 1999 |pmid= 10383413 |doi=
*cite journal | author=Bartoe JL, Nathanson NM |title=Differential regulation of leukemia inhibitory factor-stimulated neuronal gene expression by protein phosphatases SHP-1 and SHP-2 through mitogen-activated protein kinase-dependent and -independent pathways. |journal=J. Neurochem. |volume=74 |issue= 5 |pages= 2021–32 |year= 2000 |pmid= 10800945 |doi=
*cite journal | author=Bamberger AM, Schulte HM, Wullbrand A, "et al." |title=Expression of leukemia inhibitory factor (LIF) and LIF receptor (LIF-R) in the human adrenal cortex: implications for steroidogenesis. |journal=Mol. Cell. Endocrinol. |volume=162 |issue= 1-2 |pages= 145–9 |year= 2000 |pmid= 10854707 |doi=
*cite journal | author=Blanchard F, Duplomb L, Wang Y, "et al." |title=Stimulation of leukemia inhibitory factor receptor degradation by extracellular signal-regulated kinase. |journal=J. Biol. Chem. |volume=275 |issue= 37 |pages= 28793–801 |year= 2000 |pmid= 10858440 |doi= 10.1074/jbc.M003986200
*cite journal | author=Plun-Favreau H, Elson G, Chabbert M, "et al." |title=The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine. |journal=EMBO J. |volume=20 |issue= 7 |pages= 1692–703 |year= 2001 |pmid= 11285233 |doi= 10.1093/emboj/20.7.1692

External links

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