NCR1

Natural cytotoxicity triggering receptor 1
PDB rendering based on 1oll.
Available structures PDB 1OLL, 1P6F
Identifiers
Symbols	NCR1; CD335; FLJ99094; LY94; NK-p46; NKP46
External IDs	OMIM: 604530 MGI: 1336212 HomoloGene: 3551 GeneCards: NCR1 Gene
Gene Ontology Molecular function • receptor activity • receptor signaling protein activity Cellular component • plasma membrane • integral to plasma membrane • SWI/SNF complex Biological process • cellular defense response • signal transduction • natural killer cell activation • regulation of natural killer cell mediated cytotoxicity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9437	17086
Ensembl	ENSG00000189430	ENSMUSG00000062524
UniProt	O76036	Q3T9W3
RefSeq (mRNA)	NM_001145457.1	NM_010746.3
RefSeq (protein)	NP_001138929.1	NP_034876.2
Location (UCSC)	Chr 19: 55.42 – 55.42 Mb	Chr 7: 4.29 – 4.3 Mb
PubMed search	[1]	[2]

Natural cytotoxicity triggering receptor 1 is a protein that in humans is encoded by the NCR1 gene.^[1][2] NCR1 has also been designated as CD335 (cluster of differentiation 335).

References

1. ^ Pessino A, Sivori S, Bottino C, Malaspina A, Morelli L, Moretta L, Biassoni R, Moretta A (Sep 1998). "Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity". J Exp Med 188 (5): 953–60. doi:10.1084/jem.188.5.953. PMID 9730896. 
2. ^ "Entrez Gene: NCR1 natural cytotoxicity triggering receptor 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9437. 

Further reading

• Biassoni R, Cantoni C, Marras D et al. (2004). "Human natural killer cell receptors: insights into their molecular function and structure". J. Cell. Mol. Med. 7 (4): 376–87. doi:10.1111/j.1582-4934.2003.tb00240.x. PMID 14754506. 
• Sivori S, Vitale M, Morelli L et al. (1997). "p46, a Novel Natural Killer Cell–specific Surface Molecule That Mediates Cell Activation". J. Exp. Med. 186 (7): 1129–36. doi:10.1084/jem.186.7.1129. PMC 2211712. PMID 9314561. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2211712. 
• Vitale M, Bottino C, Sivori S et al. (1998). "NKp44, a Novel Triggering Surface Molecule Specifically Expressed by Activated Natural Killer Cells, Is Involved in Non–Major Histocompatibility Complex–restricted Tumor Cell Lysis". J. Exp. Med. 187 (12): 2065–72. doi:10.1084/jem.187.12.2065. PMC 2212362. PMID 9625766. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2212362. 
• Cantoni C, Bottino C, Vitale M et al. (1999). "NKp44, A Triggering Receptor Involved in Tumor Cell Lysis by Activated Human Natural Killer Cells, Is a Novel Member of the Immunoglobulin Superfamily". J. Exp. Med. 189 (5): 787–96. doi:10.1084/jem.189.5.787. PMC 2192947. PMID 10049942. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2192947. 
• Vankayalapati R, Wizel B, Weis SE et al. (2002). "The NKp46 receptor contributes to NK cell lysis of mononuclear phagocytes infected with an intracellular bacterium". J. Immunol. 168 (7): 3451–7. PMID 11907104. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Augugliaro R, Parolini S, Castriconi R et al. (2003). "Selective cross-talk among natural cytotoxicity receptors in human natural killer cells". Eur. J. Immunol. 33 (5): 1235–41. doi:10.1002/eji.200323896. PMID 12731048. 
• Ponassi M, Cantoni C, Biassoni R et al. (2003). "Structure of the human NK cell triggering receptor NKp46 ectodomain". Biochem. Biophys. Res. Commun. 309 (2): 317–23. doi:10.1016/j.bbrc.2003.08.007. PMID 12951052. 
• Foster CE, Colonna M, Sun PD (2003). "Crystal structure of the human natural killer (NK) cell activating receptor NKp46 reveals structural relationship to other leukocyte receptor complex immunoreceptors". J. Biol. Chem. 278 (46): 46081–6. doi:10.1074/jbc.M308491200. PMID 12960161. 
• Arnon TI, Achdout H, Lieberman N et al. (2004). "The mechanisms controlling the recognition of tumor- and virus-infected cells by NKp46". Blood 103 (2): 664–72. doi:10.1182/blood-2003-05-1716. PMID 14504081. 
• Marcenaro E, Augugliaro R, Falco M et al. (2004). "CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity". Eur. J. Immunol. 33 (12): 3367–76. doi:10.1002/eji.200324425. PMID 14635045. 
• Carbone E, Neri P, Mesuraca M et al. (2005). "HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells". Blood 105 (1): 251–8. doi:10.1182/blood-2004-04-1422. PMID 15328155. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Mavoungou E, Bouyou-Akotet MK, Kremsner PG (2005). "Effects of prolactin and cortisol on natural killer (NK) cell surface expression and function of human natural cytotoxicity receptors (NKp46, NKp44 and NKp30)". Clin. Exp. Immunol. 139 (2): 287–96. doi:10.1111/j.1365-2249.2004.02686.x. PMC 1809301. PMID 15654827. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1809301. 
• Nowbakht P, Ionescu MC, Rohner A et al. (2005). "Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias". Blood 105 (9): 3615–22. doi:10.1182/blood-2004-07-2585. PMID 15657183. 
• Poggi A, Massaro AM, Negrini S et al. (2005). "Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors". J. Immunol. 174 (5): 2653–60. PMID 15728472. 
• Zilka A, Landau G, Hershkovitz O et al. (2006). "Characterization of the heparin/heparan sulfate binding site of the natural cytotoxicity receptor NKp46". Biochemistry 44 (44): 14477–85. doi:10.1021/bi051241s. PMID 16262248. 
• Hermann E, Alonso-Vega C, Berthe A et al. (2006). "Human congenital infection with Trypanosoma cruzi induces phenotypic and functional modifications of cord blood NK cells". Pediatr. Res. 60 (1): 38–43. doi:10.1203/01.pdr.0000220335.05588.ea. PMID 16690951. 

External links

• MeSH NCR1+protein,+human

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