Tumor necrosis factor (ligand) superfamily, member 14, also known as TNFSF14, is a human gene.cite web | title = Entrez Gene: TNFSF14 tumor necrosis factor (ligand) superfamily, member 14| url =| accessdate = ] TNFSF14 has also been designated as CD258 (cluster of differentiation 258).

section_title =
summary_text = The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.cite web | title = Entrez Gene: TNFSF14 tumor necrosis factor (ligand) superfamily, member 14| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Yang D, Zhai Y, Zhang M |title=LIGHT, a new member of the TNF superfamily. |journal=J. Biol. Regul. Homeost. Agents |volume=16 |issue= 3 |pages= 206–10 |year= 2003 |pmid= 12456019 |doi=
*cite journal | author=Bénichou S, Benmerah A |title= [The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway] |journal=Med Sci (Paris) |volume=19 |issue= 1 |pages= 100–6 |year= 2003 |pmid= 12836198 |doi=
*cite journal | author=Anderson JL, Hope TJ |title=HIV accessory proteins and surviving the host cell. |journal=Current HIV/AIDS reports |volume=1 |issue= 1 |pages= 47–53 |year= 2005 |pmid= 16091223 |doi=
*cite journal | author=Mauri DN, Ebner R, Montgomery RI, "et al." |title=LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator. |journal=Immunity |volume=8 |issue= 1 |pages= 21–30 |year= 1998 |pmid= 9462508 |doi=
*cite journal | author=Marsters SA, Sheridan JP, Pitti RM, "et al." |title=Identification of a ligand for the death-domain-containing receptor Apo3. |journal=Curr. Biol. |volume=8 |issue= 9 |pages= 525–8 |year= 1998 |pmid= 9560343 |doi=
*cite journal | author=Zhai Y, Guo R, Hsu TL, "et al." |title=LIGHT, a novel ligand for lymphotoxin beta receptor and TR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer. |journal=J. Clin. Invest. |volume=102 |issue= 6 |pages= 1142–51 |year= 1998 |pmid= 9739048 |doi=
*cite journal | author=Harrop JA, McDonnell PC, Brigham-Burke M, "et al." |title=Herpesvirus entry mediator ligand (HVEM-L), a novel ligand for HVEM/TR2, stimulates proliferation of T cells and inhibits HT29 cell growth. |journal=J. Biol. Chem. |volume=273 |issue= 42 |pages= 27548–56 |year= 1998 |pmid= 9765287 |doi=
*cite journal | author=Yu KY, Kwon B, Ni J, "et al." |title=A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. |journal=J. Biol. Chem. |volume=274 |issue= 20 |pages= 13733–6 |year= 1999 |pmid= 10318773 |doi=
*cite journal | author=Rooney IA, Butrovich KD, Glass AA, "et al." |title=The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells. |journal=J. Biol. Chem. |volume=275 |issue= 19 |pages= 14307–15 |year= 2000 |pmid= 10799510 |doi=
*cite journal | author=Lama J, Ware CF |title=Human immunodeficiency virus type 1 Nef mediates sustained membrane expression of tumor necrosis factor and the related cytokine LIGHT on activated T cells. |journal=J. Virol. |volume=74 |issue= 20 |pages= 9396–402 |year= 2000 |pmid= 11000208 |doi=
*cite journal | author=Morel Y, Schiano de Colella JM, Harrop J, "et al." |title=Reciprocal expression of the TNF family receptor herpes virus entry mediator and its ligand LIGHT on activated T cells: LIGHT down-regulates its own receptor. |journal=J. Immunol. |volume=165 |issue= 8 |pages= 4397–404 |year= 2000 |pmid= 11035077 |doi=
*cite journal | author=Zhang J, Salcedo TW, Wan X, "et al." |title=Modulation of T-cell responses to alloantigens by TR6/DcR3. |journal=J. Clin. Invest. |volume=107 |issue= 11 |pages= 1459–68 |year= 2001 |pmid= 11390428 |doi=
*cite journal | author=Granger SW, Butrovich KD, Houshmand P, "et al." |title=Genomic characterization of LIGHT reveals linkage to an immune response locus on chromosome 19p13.3 and distinct isoforms generated by alternate splicing or proteolysis. |journal=J. Immunol. |volume=167 |issue= 9 |pages= 5122–8 |year= 2001 |pmid= 11673523 |doi=
*cite journal | author=Shaikh RB, Santee S, Granger SW, "et al." |title=Constitutive expression of LIGHT on T cells leads to lymphocyte activation, inflammation, and tissue destruction. |journal=J. Immunol. |volume=167 |issue= 11 |pages= 6330–7 |year= 2002 |pmid= 11714797 |doi=
*cite journal | author=Bobik A, Kalinina N |title=Tumor necrosis factor receptor and ligand superfamily family members TNFRSF14 and LIGHT: new players in human atherogenesis. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=21 |issue= 12 |pages= 1873–5 |year= 2002 |pmid= 11742858 |doi=
*cite journal | author=Wang J, Lo JC, Foster A, "et al." |title=The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT. |journal=J. Clin. Invest. |volume=108 |issue= 12 |pages= 1771–80 |year= 2002 |pmid= 11748260 |doi=
*cite journal | author=Hsu TL, Chang YC, Chen SJ, "et al." |title=Modulation of dendritic cell differentiation and maturation by decoy receptor 3. |journal=J. Immunol. |volume=168 |issue= 10 |pages= 4846–53 |year= 2002 |pmid= 11994433 |doi=
*cite journal | author=Castellano R, Van Lint C, Peri V, "et al." |title=Mechanisms regulating expression of the tumor necrosis factor-related light gene. Role of calcium-signaling pathway in the transcriptional control. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 42841–51 |year= 2003 |pmid= 12215452 |doi= 10.1074/jbc.M207689200
*cite journal | author=Matsui H, Hikichi Y, Tsuji I, "et al." |title=LIGHT, a member of the tumor necrosis factor ligand superfamily, prevents tumor necrosis factor-alpha-mediated human primary hepatocyte apoptosis, but not Fas-mediated apoptosis. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 50054–61 |year= 2003 |pmid= 12393901 |doi= 10.1074/jbc.M206562200

External links


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