Tumor necrosis factor receptor superfamily, member 6b, decoy
Symbols TNFRSF6B; DCR3; DJ583P15.1.1; M68; TR6
External IDs OMIM603361 HomoloGene48242 GeneCards: TNFRSF6B Gene
Species Human Mouse
Entrez 8771 n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) NM_003823.3 n/a
RefSeq (protein) NP_003814.1 n/a
Location (UCSC) n/a n/a
PubMed search [1] n/a

Tumor necrosis factor receptor superfamily member 6B is a protein that in humans is encoded by the TNFRSF6B gene.[1][2][3]

This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Overexpression of this gene has been noted in gastrointestinal tract tumors, and it is located in a gene-rich cluster on chromosome 20, with other potentially tumor-related genes. Two transcript variants encoding the same isoform, but differing in the 5' UTR, have been observed for this gene.[3]



TNFRSF6B has been shown to interact with TNFSF14[2][4][5] and Fas ligand.[1][2][5]


  1. ^ a b Pitti RM, Marsters SA, Lawrence DA, Roy M, Kischkel FC, Dowd P, Huang A, Donahue CJ, Sherwood SW, Baldwin DT, Godowski PJ, Wood WI, Gurney AL, Hillan KJ, Cohen RL, Goddard AD, Botstein D, Ashkenazi A (Jan 1999). "Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer". Nature 396 (6712): 699–703. doi:10.1038/25387. PMID 9872321. 
  2. ^ a b c Yu KY, Kwon B, Ni J, Zhai Y, Ebner R, Kwon BS (Jun 1999). "A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis". J Biol Chem 274 (20): 13733–6. doi:10.1074/jbc.274.20.13733. PMID 10318773. 
  3. ^ a b "Entrez Gene: TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy". 
  4. ^ Zhang, J; Salcedo T W, Wan X, Ullrich S, Hu B, Gregorio T, Feng P, Qi S, Chen H, Cho Y H, Li Y, Moore P A, Wu J (Jun. 2001). "Modulation of T-cell responses to alloantigens by TR6/DcR3". J. Clin. Invest. (United States) 107 (11): 1459–68. doi:10.1172/JCI12159. ISSN 0021-9738. PMC 209323. PMID 11390428. 
  5. ^ a b Hsu, Tsui-Ling; Chang Yung-Chi, Chen Siu-Ju, Liu Yong-Jun, Chiu Allen W, Chio Chung-Ching, Chen Lieping, Hsieh Shie-Liang (May. 2002). "Modulation of dendritic cell differentiation and maturation by decoy receptor 3". J. Immunol. (United States) 168 (10): 4846–53. ISSN 0022-1767. PMID 11994433. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.