TNFRSF6B

Tumor necrosis factor receptor superfamily, member 6b, decoy
Identifiers
Symbols	TNFRSF6B; DCR3; DJ583P15.1.1; M68; TR6
External IDs	OMIM: 603361 HomoloGene: 48242 GeneCards: TNFRSF6B Gene
Gene Ontology Molecular function • receptor activity • protein binding Cellular component • extracellular region • soluble fraction Biological process • apoptosis • anti-apoptosis
Orthologs
Species	Human	Mouse
Entrez	8771	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	NM_003823.3	n/a
RefSeq (protein)	NP_003814.1	n/a
Location (UCSC)	n/a	n/a
PubMed search	[1]	n/a

Tumor necrosis factor receptor superfamily member 6B is a protein that in humans is encoded by the TNFRSF6B gene.^[1][2][3]

This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Overexpression of this gene has been noted in gastrointestinal tract tumors, and it is located in a gene-rich cluster on chromosome 20, with other potentially tumor-related genes. Two transcript variants encoding the same isoform, but differing in the 5' UTR, have been observed for this gene.^[3]

Interactions

TNFRSF6B has been shown to interact with TNFSF14^[2][4][5] and Fas ligand.^[1][2][5]

References

1. ^ ^{a b} Pitti RM, Marsters SA, Lawrence DA, Roy M, Kischkel FC, Dowd P, Huang A, Donahue CJ, Sherwood SW, Baldwin DT, Godowski PJ, Wood WI, Gurney AL, Hillan KJ, Cohen RL, Goddard AD, Botstein D, Ashkenazi A (Jan 1999). "Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer". Nature 396 (6712): 699–703. doi:10.1038/25387. PMID 9872321. 
2. ^ ^{a b c} Yu KY, Kwon B, Ni J, Zhai Y, Ebner R, Kwon BS (Jun 1999). "A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis". J Biol Chem 274 (20): 13733–6. doi:10.1074/jbc.274.20.13733. PMID 10318773. 
3. ^ ^{a b} "Entrez Gene: TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8771. 
4. ^ Zhang, J; Salcedo T W, Wan X, Ullrich S, Hu B, Gregorio T, Feng P, Qi S, Chen H, Cho Y H, Li Y, Moore P A, Wu J (Jun. 2001). "Modulation of T-cell responses to alloantigens by TR6/DcR3". J. Clin. Invest. (United States) 107 (11): 1459–68. doi:10.1172/JCI12159. ISSN 0021-9738. PMC 209323. PMID 11390428. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=209323. 
5. ^ ^{a b} Hsu, Tsui-Ling; Chang Yung-Chi, Chen Siu-Ju, Liu Yong-Jun, Chiu Allen W, Chio Chung-Ching, Chen Lieping, Hsieh Shie-Liang (May. 2002). "Modulation of dendritic cell differentiation and maturation by decoy receptor 3". J. Immunol. (United States) 168 (10): 4846–53. ISSN 0022-1767. PMID 11994433. 

Further reading

• Kikuno R, Nagase T, Ishikawa K et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851. 
• Bai C, Connolly B, Metzker ML et al. (2000). "Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster". Proc. Natl. Acad. Sci. U.S.A. 97 (3): 1230–5. doi:10.1073/pnas.97.3.1230. PMC 15578. PMID 10655513. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=15578. 
• Deloukas P, Matthews LH, Ashurst J et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. 
• Migone TS, Zhang J, Luo X et al. (2002). "TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator". Immunity 16 (3): 479–92. doi:10.1016/S1074-7613(02)00283-2. PMID 11911831. 
• Hsu TL, Chang YC, Chen SJ et al. (2002). "Modulation of dendritic cell differentiation and maturation by decoy receptor 3". J. Immunol. 168 (10): 4846–53. PMID 11994433. 
• Mild G, Bachmann F, Boulay JL et al. (2002). "DCR3 locus is a predictive marker for 5-fluorouracil-based adjuvant chemotherapy in colorectal cancer". Int. J. Cancer 102 (3): 254–7. doi:10.1002/ijc.10711. PMID 12397645. 
• Gill RM, Ni J, Hunt JS (2003). "Differential Expression of LIGHT and Its Receptors in Human Placental Villi and Amniochorion Membranes". Am. J. Pathol. 161 (6): 2011–7. doi:10.1016/S0002-9440(10)64479-3. PMC 1850908. PMID 12466117. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1850908. 
• Wan X, Zhang J, Luo H et al. (2003). "A TNF family member LIGHT transduces costimulatory signals into human T cells". J. Immunol. 169 (12): 6813–21. PMID 12471113. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Wan X, Shi G, Semenuk M et al. (2003). "DcR3/TR6 modulates immune cell interactions". J. Cell. Biochem. 89 (3): 603–12. doi:10.1002/jcb.10523. PMID 12761893. 
• Tsuji S, Hosotani R, Yonehara S et al. (2003). "Endogenous decoy receptor 3 blocks the growth inhibition signals mediated by Fas ligand in human pancreatic adenocarcinoma". Int. J. Cancer 106 (1): 17–25. doi:10.1002/ijc.11170. PMID 12794752. 
• Clark HF, Gurney AL, Abaya E et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697. 
• Shi G, Wu Y, Zhang J, Wu J (2004). "Death decoy receptor TR6/DcR3 inhibits T cell chemotaxis in vitro and in vivo". J. Immunol. 171 (7): 3407–14. PMID 14500635. 
• Wu SF, Liu TM, Lin YC et al. (2004). "Immunomodulatory effect of decoy receptor 3 on the differentiation and function of bone marrow-derived dendritic cells in nonobese diabetic mice: from regulatory mechanism to clinical implication". J. Leukoc. Biol. 75 (2): 293–306. doi:10.1189/jlb.0303119. PMID 14634066. 
• Chang YC, Hsu TL, Lin HH et al. (2004). "Modulation of macrophage differentiation and activation by decoy receptor 3". J. Leukoc. Biol. 75 (3): 486–94. doi:10.1189/jlb.0903448. PMID 14657214. 
• Kim S, McAuliffe WJ, Zaritskaya LS et al. (2004). "Selective Induction of Tumor Necrosis Receptor Factor 6/Decoy Receptor 3 Release by Bacterial Antigens in Human Monocytes and Myeloid Dendritic Cells". Infect. Immun. 72 (1): 89–93. doi:10.1128/IAI.72.1.89-93.2004. PMC 343977. PMID 14688085. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=343977. 
• Hsu MJ, Lin WW, Tsao WC et al. (2004). "Enhanced adhesion of monocytes via reverse signaling triggered by decoy receptor 3". Exp. Cell Res. 292 (2): 241–51. doi:10.1016/j.yexcr.2003.09.019. PMID 14697332. 
• Gill RM, Hunt JS (2004). "Soluble Receptor (DcR3) and Cellular Inhibitor of Apoptosis-2 (cIAP-2) Protect Human Cytotrophoblast Cells Against LIGHT-Mediated Apoptosis". Am. J. Pathol. 165 (1): 309–17. doi:10.1016/S0002-9440(10)63298-1. PMC 1618528. PMID 15215185. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1618528. 

External links

• GeneReviews/NCBI/NIH/UW entry on Autoimmune Lymphoproliferative Syndrome

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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