TNFRSF25

Tumor necrosis factor receptor superfamily, member 25, also known as TNFRSF25, is a human gene.cite web | title = Entrez Gene: TNFRSF25 tumor necrosis factor receptor superfamily, member 25| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8718| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.cite web | title = Entrez Gene: TNFRSF25 tumor necrosis factor receptor superfamily, member 25| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8718| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Metheny-Barlow LJ, Li LY |title=Vascular endothelial growth inhibitor (VEGI), an endogenous negative regulator of angiogenesis. |journal=Seminars in ophthalmology |volume=21 |issue= 1 |pages= 49–58 |year= 2006 |pmid= 16517446 |doi= 10.1080/08820530500511446
*cite journal | author=Chinnaiyan AM, O'Rourke K, Yu GL, "et al." |title=Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. |journal=Science |volume=274 |issue= 5289 |pages= 990–2 |year= 1996 |pmid= 8875942 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Kitson J, Raven T, Jiang YP, "et al." |title=A death-domain-containing receptor that mediates apoptosis. |journal=Nature |volume=384 |issue= 6607 |pages= 372–5 |year= 1996 |pmid= 8934525 |doi= 10.1038/384372a0
*cite journal | author=Marsters SA, Sheridan JP, Donahue CJ, "et al." |title=Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-kappa B. |journal=Curr. Biol. |volume=6 |issue= 12 |pages= 1669–76 |year= 1997 |pmid= 8994832 |doi=
*cite journal | author=Bodmer JL, Burns K, Schneider P, "et al." |title=TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95). |journal=Immunity |volume=6 |issue= 1 |pages= 79–88 |year= 1997 |pmid= 9052839 |doi=
*cite journal | author=Screaton GR, Xu XN, Olsen AL, "et al." |title=LARD: a new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 9 |pages= 4615–9 |year= 1997 |pmid= 9114039 |doi=
*cite journal | author=Warzocha K, Ribeiro P, Charlot C, "et al." |title=A new death receptor 3 isoform: expression in human lymphoid cell lines and non-Hodgkin's lymphomas. |journal=Biochem. Biophys. Res. Commun. |volume=242 |issue= 2 |pages= 376–9 |year= 1998 |pmid= 9446802 |doi= 10.1006/bbrc.1997.7948
*cite journal | author=Grenet J, Valentine V, Kitson J, "et al." |title=Duplication of the DR3 gene on human chromosome 1p36 and its deletion in human neuroblastoma. |journal=Genomics |volume=49 |issue= 3 |pages= 385–93 |year= 1998 |pmid= 9615223 |doi= 10.1006/geno.1998.5300
*cite journal | author=Jiang Y, Woronicz JD, Liu W, Goeddel DV |title=Prevention of constitutive TNF receptor 1 signaling by silencer of death domains. |journal=Science |volume=283 |issue= 5401 |pages= 543–6 |year= 1999 |pmid= 9915703 |doi=
*cite journal | author=Kaptein A, Jansen M, Dilaver G, "et al." |title=Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3). |journal=FEBS Lett. |volume=485 |issue= 2-3 |pages= 135–41 |year= 2000 |pmid= 11094155 |doi=
*cite journal | author=Frankel SK, Van Linden AA, Riches DW |title=Heterogeneity in the phosphorylation of human death receptors by p42(mapk/erk2). |journal=Biochem. Biophys. Res. Commun. |volume=288 |issue= 2 |pages= 313–20 |year= 2001 |pmid= 11606045 |doi= 10.1006/bbrc.2001.5761
*cite journal | author=Migone TS, Zhang J, Luo X, "et al." |title=TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. |journal=Immunity |volume=16 |issue= 3 |pages= 479–92 |year= 2002 |pmid= 11911831 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Al-Lamki RS, Wang J, Thiru S, "et al." |title=Expression of silencer of death domains and death-receptor-3 in normal human kidney and in rejecting renal transplants. |journal=Am. J. Pathol. |volume=163 |issue= 2 |pages= 401–11 |year= 2003 |pmid= 12875962 |doi=
*cite journal | author=Wen L, Zhuang L, Luo X, Wei P |title=TL1A-induced NF-kappaB activation and c-IAP2 production prevent DR3-mediated apoptosis in TF-1 cells. |journal=J. Biol. Chem. |volume=278 |issue= 40 |pages= 39251–8 |year= 2003 |pmid= 12882979 |doi= 10.1074/jbc.M305833200
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance. |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8
*cite journal | author=Osawa K, Takami N, Shiozawa K, "et al." |title=Death receptor 3 (DR3) gene duplication in a chromosome region 1p36.3: gene duplication is more prevalent in rheumatoid arthritis. |journal=Genes Immun. |volume=5 |issue= 6 |pages= 439–43 |year= 2005 |pmid= 15241467 |doi= 10.1038/sj.gene.6364097

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