TNFRSF10A

TNFRSF10A

Tumor necrosis factor receptor superfamily, member 10a, also known as TNFRSF10A, is a human gene.

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summary_text = The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.cite web | title = Entrez Gene: TNFRSF10A tumor necrosis factor receptor superfamily, member 10a| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8797| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kimberley FC, Screaton GR |title=Following a TRAIL: update on a ligand and its five receptors. |journal=Cell Res. |volume=14 |issue= 5 |pages= 359–72 |year= 2005 |pmid= 15538968 |doi= 10.1038/sj.cr.7290236
*cite journal | author=Fleury S, Thibodeau J, Croteau G, "et al." |title=HLA-DR polymorphism affects the interaction with CD4. |journal=J. Exp. Med. |volume=182 |issue= 3 |pages= 733–41 |year= 1995 |pmid= 7650480 |doi=
*cite journal | author=Pan G, O'Rourke K, Chinnaiyan AM, "et al." |title=The receptor for the cytotoxic ligand TRAIL. |journal=Science |volume=276 |issue= 5309 |pages= 111–3 |year= 1997 |pmid= 9082980 |doi=
*cite journal | author=Walczak H, Degli-Esposti MA, Johnson RS, "et al." |title=TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. |journal=EMBO J. |volume=16 |issue= 17 |pages= 5386–97 |year= 1997 |pmid= 9311998 |doi= 10.1093/emboj/16.17.5386
*cite journal | author=MacFarlane M, Ahmad M, Srinivasula SM, "et al." |title=Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. |journal=J. Biol. Chem. |volume=272 |issue= 41 |pages= 25417–20 |year= 1997 |pmid= 9325248 |doi=
*cite journal | author=Schneider P, Bodmer JL, Thome M, "et al." |title=Characterization of two receptors for TRAIL. |journal=FEBS Lett. |volume=416 |issue= 3 |pages= 329–34 |year= 1997 |pmid= 9373179 |doi=
*cite journal | author=Marsters SA, Sheridan JP, Pitti RM, "et al." |title=A novel receptor for Apo2L/TRAIL contains a truncated death domain. |journal=Curr. Biol. |volume=7 |issue= 12 |pages= 1003–6 |year= 1998 |pmid= 9382840 |doi=
*cite journal | author=Chaudhary PM, Eby M, Jasmin A, "et al." |title=Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway. |journal=Immunity |volume=7 |issue= 6 |pages= 821–30 |year= 1998 |pmid= 9430227 |doi=
*cite journal | author=Schneider P, Thome M, Burns K, "et al." |title=TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB. |journal=Immunity |volume=7 |issue= 6 |pages= 831–6 |year= 1998 |pmid= 9430228 |doi=
*cite journal | author=Diab BY, Lambert NC, L'Faqihi FE, "et al." |title=Human collagen II peptide 256-271 preferentially binds to HLA-DR molecules associated with susceptibility to rheumatoid arthritis. |journal=Immunogenetics |volume=49 |issue= 1 |pages= 36–44 |year= 1999 |pmid= 9811967 |doi=
*cite journal | author=Costanzo A, Guiet C, Vito P |title=c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB. |journal=J. Biol. Chem. |volume=274 |issue= 29 |pages= 20127–32 |year= 1999 |pmid= 10400625 |doi=
*cite journal | author=Hymowitz SG, Christinger HW, Fuh G, "et al." |title=Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5. |journal=Mol. Cell |volume=4 |issue= 4 |pages= 563–71 |year= 1999 |pmid= 10549288 |doi=
*cite journal | author=Gibson SB, Oyer R, Spalding AC, "et al." |title=Increased expression of death receptors 4 and 5 synergizes the apoptosis response to combined treatment with etoposide and TRAIL. |journal=Mol. Cell. Biol. |volume=20 |issue= 1 |pages= 205–12 |year= 2000 |pmid= 10594023 |doi=
*cite journal | author=Kuang AA, Diehl GE, Zhang J, Winoto A |title=FADD is required for DR4- and DR5-mediated apoptosis: lack of trail-induced apoptosis in FADD-deficient mouse embryonic fibroblasts. |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25065–8 |year= 2000 |pmid= 10862756 |doi= 10.1074/jbc.C000284200
*cite journal | author=Miyazaki T, Reed JC |title=A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins. |journal=Nat. Immunol. |volume=2 |issue= 6 |pages= 493–500 |year= 2001 |pmid= 11376335 |doi= 10.1038/88684
*cite journal | author=Trauzold A, Wermann H, Arlt A, "et al." |title=CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells. |journal=Oncogene |volume=20 |issue= 31 |pages= 4258–69 |year= 2001 |pmid= 11464292 |doi= 10.1038/sj.onc.1204559
*cite journal | author=Dörr J, Bechmann I, Waiczies S, "et al." |title=Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain. |journal=J. Neurosci. |volume=22 |issue= 4 |pages= RC209 |year= 2002 |pmid= 11844843 |doi=
*cite journal | author=Koyama S, Koike N, Adachi S |title=Expression of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in gastric carcinoma and tumor-infiltrating lymphocytes: a possible mechanism of immune evasion of the tumor. |journal=J. Cancer Res. Clin. Oncol. |volume=128 |issue= 2 |pages= 73–9 |year= 2002 |pmid= 11862476 |doi= 10.1007/s004320100292
*cite journal | author=Guan B, Yue P, Lotan R, Sun SY |title=Evidence that the human death receptor 4 is regulated by activator protein 1. |journal=Oncogene |volume=21 |issue= 20 |pages= 3121–9 |year= 2002 |pmid= 12082627 |doi= 10.1038/sj.onc.1205430
*cite journal | author=Söderström TS, Poukkula M, Holmström TH, "et al." |title=Mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in activated T cells abrogates TRAIL-induced apoptosis upstream of the mitochondrial amplification loop and caspase-8. |journal=J. Immunol. |volume=169 |issue= 6 |pages= 2851–60 |year= 2002 |pmid= 12218097 |doi=

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