TNFRSF13C

Tumor necrosis factor receptor superfamily, member 13C, also known as TNFRSF13C, is a human gene.cite web | title = Entrez Gene: TNFRSF13C tumor necrosis factor receptor superfamily, member 13C| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=115650| accessdate = ]

PBB_Summary
section_title =
summary_text = B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.cite web | title = Entrez Gene: TNFRSF13C tumor necrosis factor receptor superfamily, member 13C| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=115650| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Laâbi Y, Egle A, Strasser A |title=TNF cytokine family: more BAFF-ling complexities. |journal=Curr. Biol. |volume=11 |issue= 24 |pages= R1013–6 |year= 2002 |pmid= 11747837 |doi=
*cite journal | author=Defrance T, Casamayor-Pallejà M, Krammer PH |title=The life and death of a B cell. |journal=Adv. Cancer Res. |volume=86 |issue= |pages= 195–225 |year= 2003 |pmid= 12374279 |doi=
*cite journal | author=Ambrose CM |title=BAFF-R. |journal=J. Biol. Regul. Homeost. Agents |volume=16 |issue= 3 |pages= 211–3 |year= 2003 |pmid= 12456020 |doi=
*cite journal | author=Bossen C, Schneider P |title=BAFF, APRIL and their receptors: structure, function and signaling. |journal=Semin. Immunol. |volume=18 |issue= 5 |pages= 263–75 |year= 2007 |pmid= 16914324 |doi= 10.1016/j.smim.2006.04.006
*cite journal | author=Treml LS, Crowley JE, Cancro MP |title=BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells. |journal=Semin. Immunol. |volume=18 |issue= 5 |pages= 297–304 |year= 2007 |pmid= 16919470 |doi= 10.1016/j.smim.2006.07.001
*cite journal | author=Kalled SL |title=Impact of the BAFF/BR3 axis on B cell survival, germinal center maintenance and antibody production. |journal=Semin. Immunol. |volume=18 |issue= 5 |pages= 290–6 |year= 2007 |pmid= 16931038 |doi= 10.1016/j.smim.2006.06.002
*cite journal | author=Mackay F, Leung H |title=The role of the BAFF/APRIL system on T cell function. |journal=Semin. Immunol. |volume=18 |issue= 5 |pages= 284–9 |year= 2007 |pmid= 16931039 |doi= 10.1016/j.smim.2006.04.005
*cite journal | author=Schneider P, MacKay F, Steiner V, "et al." |title=BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. |journal=J. Exp. Med. |volume=189 |issue= 11 |pages= 1747–56 |year= 1999 |pmid= 10359578 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Thompson JS, Bixler SA, Qian F, "et al." |title=BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. |journal=Science |volume=293 |issue= 5537 |pages= 2108–11 |year= 2001 |pmid= 11509692 |doi= 10.1126/science.1061965
*cite journal | author=Yan M, Brady JR, Chan B, "et al." |title=Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency. |journal=Curr. Biol. |volume=11 |issue= 19 |pages= 1547–52 |year= 2002 |pmid= 11591325 |doi=
*cite journal | author=Rolink AG, Melchers F |title=BAFFled B cells survive and thrive: roles of BAFF in B-cell development. |journal=Curr. Opin. Immunol. |volume=14 |issue= 2 |pages= 266–75 |year= 2002 |pmid= 11869903 |doi=
*cite journal | author=Xu LG, Shu HB |title=TNFR-associated factor-3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kappa B activation and IL-10 production. |journal=J. Immunol. |volume=169 |issue= 12 |pages= 6883–9 |year= 2003 |pmid= 12471121 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kim HM, Yu KS, Lee ME, "et al." |title=Crystal structure of the BAFF-BAFF-R complex and its implications for receptor activation. |journal=Nat. Struct. Biol. |volume=10 |issue= 5 |pages= 342–8 |year= 2003 |pmid= 12715002 |doi= 10.1038/nsb925
*cite journal | author=Liu Y, Hong X, Kappler J, "et al." |title=Ligand-receptor binding revealed by the TNF family member TALL-1. |journal=Nature |volume=423 |issue= 6935 |pages= 49–56 |year= 2003 |pmid= 12721620 |doi= 10.1038/nature01543
*cite journal | author=Gordon NC, Pan B, Hymowitz SG, "et al." |title=BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site. |journal=Biochemistry |volume=42 |issue= 20 |pages= 5977–83 |year= 2003 |pmid= 12755599 |doi= 10.1021/bi034017g

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