CCR10

Chemokine (C-C motif) receptor 10, also known as CCR10, is a human gene.cite web | title = Entrez Gene: CCR10 chemokine (C-C motif) receptor 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2826| accessdate = ]

PBB_Summary
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summary_text = Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002). [supplied by OMIM] cite web | title = Entrez Gene: CCR10 chemokine (C-C motif) receptor 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2826| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Marchese A, Docherty JM, Nguyen T, "et al." |title=Cloning of human genes encoding novel G protein-coupled receptors. |journal=Genomics |volume=23 |issue= 3 |pages= 609–18 |year= 1995 |pmid= 7851889 |doi= 10.1006/geno.1994.1549
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Bonini JA, Martin SK, Dralyuk F, "et al." |title=Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3. |journal=DNA Cell Biol. |volume=16 |issue= 10 |pages= 1249–56 |year= 1997 |pmid= 9364936 |doi=
*cite journal | author=Gosling J, Dairaghi DJ, Wang Y, "et al." |title=Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK. |journal=J. Immunol. |volume=164 |issue= 6 |pages= 2851–6 |year= 2000 |pmid= 10706668 |doi=
*cite journal | author=Jarmin DI, Rits M, Bota D, "et al." |title=Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine. |journal=J. Immunol. |volume=164 |issue= 7 |pages= 3460–4 |year= 2000 |pmid= 10725696 |doi=
*cite journal | author=Homey B, Wang W, Soto H, "et al." |title=Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). |journal=J. Immunol. |volume=164 |issue= 7 |pages= 3465–70 |year= 2000 |pmid= 10725697 |doi=
*cite journal | author=Wang W, Soto H, Oldham ER, "et al." |title=Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 22313–23 |year= 2000 |pmid= 10781587 |doi= 10.1074/jbc.M001461200
*cite journal | author=Pan J, Kunkel EJ, Gosslar U, "et al." |title=A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues. |journal=J. Immunol. |volume=165 |issue= 6 |pages= 2943–9 |year= 2000 |pmid= 10975800 |doi=
*cite journal | author=Patel L, Charlton SJ, Chambers JK, Macphee CH |title=Expression and functional analysis of chemokine receptors in human peripheral blood leukocyte populations. |journal=Cytokine |volume=14 |issue= 1 |pages= 27–36 |year= 2001 |pmid= 11298490 |doi= 10.1006/cyto.2000.0851
*cite journal | author=Homey B, Alenius H, Müller A, "et al." |title=CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. |journal=Nat. Med. |volume=8 |issue= 2 |pages= 157–65 |year= 2002 |pmid= 11821900 |doi= 10.1038/nm0202-157
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Lehner B, Semple JI, Brown SE, "et al." |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. |journal=Genomics |volume=83 |issue= 1 |pages= 153–67 |year= 2004 |pmid= 14667819 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Notohamiprodjo M, Segerer S, Huss R, "et al." |title=CCR10 is expressed in cutaneous T-cell lymphoma. |journal=Int. J. Cancer |volume=115 |issue= 4 |pages= 641–7 |year= 2005 |pmid= 15700309 |doi= 10.1002/ijc.20922
*cite journal | author=Rodrigues-Lisoni FC, Mehet DK, Mehemet DK, "et al." |title=In vitro and in vivo studies on CCR10 regulation by Annexin A1. |journal=FEBS Lett. |volume=580 |issue= 5 |pages= 1431–8 |year= 2006 |pmid= 16460738 |doi= 10.1016/j.febslet.2006.01.072
*cite journal | author=Fujita Y, Abe R, Sasaki M, "et al." |title=Presence of circulating CCR10+ T cells and elevated serum CTACK/CCL27 in the early stage of mycosis fungoides. |journal=Clin. Cancer Res. |volume=12 |issue= 9 |pages= 2670–5 |year= 2006 |pmid= 16675558 |doi= 10.1158/1078-0432.CCR-05-1513
*cite journal | author=Eksteen B, Miles A, Curbishley SM, "et al." |title=Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10. |journal=J. Immunol. |volume=177 |issue= 1 |pages= 593–603 |year= 2006 |pmid= 16785557 |doi=
*cite journal | author=Harasawa H, Yamada Y, Hieshima K, "et al." |title=Survey of chemokine receptor expression reveals frequent co-expression of skin-homing CCR4 and CCR10 in adult T-cell leukemia/lymphoma. |journal=Leuk. Lymphoma |volume=47 |issue= 10 |pages= 2163–73 |year= 2007 |pmid= 17071491 |doi= 10.1080/10428190600775599

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