- CCL28
protein
Name = chemokine (C-C motif) ligand 28
caption =
width =
HGNCid = 17700
Symbol = CCL28
AltSymbols = SCYA28, MEC, CCK1
EntrezGene = 56477
OMIM = 605240
RefSeq = NM_148672
UniProt = Q9NRJ3
PDB =
ECnumber =
Chromosome = 5
Arm = p
Band = 12
LocusSupplementaryData =CCL28, also known as mucosae-associated epithelial chemokine (MEC), CCK1 and SCYA28, is a
chemokine . CCL28 regulates the chemotaxis of cells that express thechemokine receptor s CCR3 and CCR10. CCL28 is expressed bycolumnar epithelial cell s in thegut ,lung ,breast and thesalivary gland s and drives the mucosal homing of T and B lymphocytes that express CCR10, and the migration of eosinophils expressing CCR3. [Rodriguez et al. 2004. Differential gene expression by integrin 7+ and 7– memory T helper cells. BMC Immunol. 5: 13.] [Kunkel et al. 2003. CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells. J. Clin. Invest. 111: 1001-1010.] [John et al. 2005, Temporal production of CCL28 corresponds to eosinophil accumulation and airway hyperreactivity in allergic airway inflammation, Am. J. Pathol. 166: 345–353.] This chemokine is constitutively expressed in the colon, but its levels can be increased by pro-inflammatorycytokine s and certain bacterial products implying a role in effector cell recruitment to sites of epithelial injury. [Hieshima et al. 2003. CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity. J. Immunol. 170: 1452-1461. ] CCL28 has also been implicated in the migration ofIgA -expressing cells to themammary gland [Wilson and Butcher. CCL28 controls immunoglobulin (Ig)A plasma cell accumulation in the lactating mammary gland and IgA antibody transfer to the neonate. J Exp Med. 2004 Sep 20;200(6):805-9.] ,salivary gland ,intestine [Feng et al. Redundant role of chemokines CCL25/TECK and CCL28/MEC in IgA+ plasmablast recruitment to the intestinal lamina propria after rotavirus infection. J Immunol. 2006 May 15;176(10):5749-59.] and othermucosal tissue s. [Lazarus et al. A common mucosal chemokine (mucosae-associated epithelial chemokine/CCL28) selectively attracts IgA plasmablasts. J Immunol. 2003 Apr 1;170(7):3799-805] It has also been shown as a potentialantimicrobial agent effective against certain pathogens, such as Gram negative and Gram positive bacteria and the fungus "Candida albicans ". [Hieshima et al. CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity. J Immunol. 2003 Feb 1;170(3):1452-61.]Human CCL28 is encoded by an
RNA transcript of 373nucleotide s and a gene with fourexon s. The gene codes for a 127-amino acid CCL28 protein with a 22-amino acid N-terminal signal peptide. It shares 76% nucleic acid identity and 83% amino acid similarity to the equivalent molecule in mouse. [Wang et al. 2000, Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). J. Biol. Chem. 275: 22313–22323.] [Pan et al. 2000, A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues, J. Immunol. 165: 2943–2949.] Sequence analysis has revealed CCL28 to be most similar to another CC chemokine called CCL27.References
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