Interleukin-27 receptor

Interleukin-27 receptor

protein
Name = interleukin 27 receptor, alpha
caption =


width =
HGNCid = 17290
Symbol = IL27RA
AltSymbols = WSX-1, TCCR, CRL1, WSX1, zcytor1, IL-27R
EntrezGene = 9466
OMIM = 605350
RefSeq = NM_004843
UniProt = Q6UWB1
PDB =
ECnumber =
Chromosome = 19
Arm = p
Band = 13.11
LocusSupplementaryData = protein
Name = Epstein-Barr virus induced gene 3
caption =


width =
HGNCid = 3129
Symbol = EBI3
AltSymbols =
EntrezGene = 10148
OMIM = 605816
RefSeq = NM_005755
UniProt = Q14213
PDB =
ECnumber =
Chromosome = 19
Arm = p
Band = 13
LocusSupplementaryData = The interleukin-27 receptor is a type I cytokine receptor for interleukin-27. It is a heterodimer composed of the interleukin 27 receptor, alpha subunitcite journal | author = Sprecher CA, Grant FJ, Baumgartner JW, Presnell SR, Schrader SK, Yamagiwa T, Whitmore TE, O'Hara PJ, Foster DF | title = Cloning and characterization of a novel class I cytokine receptor | journal = Biochem. Biophys. Res. Commun. | volume = 246 | issue = 1 | pages = 82–90 | year = 1998 | pmid = 9600072 | doi = 10.1006/bbrc.1998.8576 ] cite journal | author = Chen Q, Ghilardi N, Wang H, Baker T, Xie MH, Gurney A, Grewal IS, de Sauvage FJ | title = Development of Th1-type immune responses requires the type I cytokine receptor TCCR | journal = Nature | volume = 407 | issue = 6806 | pages = 916–20 | year = 2000 | pmid = 11057672 | doi = 10.1038/35038103 ] and EBI3.cite journal | author = Devergne O, Hummel M, Koeppen H, Le Beau MM, Nathanson EC, Kieff E, Birkenbach M | title = A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes | journal = J. Virol. | volume = 70 | issue = 2 | pages = 1143–53 | year = 1996 | month = February | pmid = 8551575 | pmc = 189923 | url = http://jvi.asm.org/cgi/content/abstract/70/2/1143 | issn = ]

IL27RA essential for transcriptional activation of STAT1 and for augmenting the induction of T-bet expression during initiation of Th1 cell differentiation.cite journal | author = Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, Mak TW, Yoshimura A, Yoshida H | title = Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment | journal = J. Immunol. | volume = 170 | issue = 10 | pages = 4886–90 | year = 2003 | month = May | pmid = 12734330 | doi = | url = http://www.jimmunol.org/cgi/content/abstract/170/10/4886 | issn = ]

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