CCR1

Chemokine (C-C motif) receptor 1, also known as CCR1, is a human gene.

CCR1 has also recently been designated CD191 (cluster of differentiation 191).

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summary_text = This gene encodes a member of the beta chemokine receptor family, which belongs to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors, which mediate signal transduction, are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CXCR1, are found to form a gene cluster on chromosome 3p. [cite web | title = Entrez Gene: CCR1 chemokine (C-C motif) receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1230| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gerard C, Gerard NP |title=C5A anaphylatoxin and its seven transmembrane-segment receptor. |journal=Annu. Rev. Immunol. |volume=12 |issue= |pages= 775–808 |year= 1994 |pmid= 8011297 |doi= 10.1146/annurev.iy.12.040194.004015
*cite journal | author=Ruibal-Ares BH, Belmonte L, Baré PC, "et al." |title=HIV-1 infection and chemokine receptor modulation. |journal=Curr. HIV Res. |volume=2 |issue= 1 |pages= 39–50 |year= 2004 |pmid= 15053339 |doi=
*cite journal | author=Nomura H, Nielsen BW, Matsushima K |title=Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors. |journal=Int. Immunol. |volume=5 |issue= 10 |pages= 1239–49 |year= 1994 |pmid= 7505609 |doi=
*cite journal | author=Ben-Baruch A, Xu L, Young PR, "et al." |title=Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3. |journal=J. Biol. Chem. |volume=270 |issue= 38 |pages= 22123–8 |year= 1995 |pmid= 7545673 |doi=
*cite journal | author=Post TW, Bozic CR, Rothenberg ME, "et al." |title=Molecular characterization of two murine eosinophil beta chemokine receptors. |journal=J. Immunol. |volume=155 |issue= 11 |pages= 5299–305 |year= 1995 |pmid= 7594543 |doi=
*cite journal | author=Neote K, DiGregorio D, Mak JY, "et al." |title=Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor. |journal=Cell |volume=72 |issue= 3 |pages= 415–25 |year= 1993 |pmid= 7679328 |doi=
*cite journal | author=Gao JL, Kuhns DB, Tiffany HL, "et al." |title=Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor. |journal=J. Exp. Med. |volume=177 |issue= 5 |pages= 1421–7 |year= 1993 |pmid= 7683036 |doi=
*cite journal | author=Combadiere C, Ahuja SK, Van Damme J, "et al." |title=Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2B. |journal=J. Biol. Chem. |volume=270 |issue= 50 |pages= 29671–5 |year= 1996 |pmid= 8530354 |doi=
*cite journal | author=Kuang Y, Wu Y, Jiang H, Wu D |title=Selective G protein coupling by C-C chemokine receptors. |journal=J. Biol. Chem. |volume=271 |issue= 8 |pages= 3975–8 |year= 1996 |pmid= 8626727 |doi=
*cite journal | author=Boring L, Gosling J, Monteclaro FS, "et al." |title=Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9. |journal=J. Biol. Chem. |volume=271 |issue= 13 |pages= 7551–8 |year= 1996 |pmid= 8631787 |doi=
*cite journal | author=Gong X, Gong W, Kuhns DB, "et al." |title=Monocyte chemotactic protein-2 (MCP-2) uses CCR1 and CCR2B as its functional receptors. |journal=J. Biol. Chem. |volume=272 |issue= 18 |pages= 11682–5 |year= 1997 |pmid= 9115216 |doi=
*cite journal | author=Daugherty BL, Springer MS |title=The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21. |journal=Genomics |volume=41 |issue= 2 |pages= 294–5 |year= 1997 |pmid= 9143512 |doi= 10.1006/geno.1997.4626
*cite journal | author=Pakianathan DR, Kuta EG, Artis DR, "et al." |title=Distinct but overlapping epitopes for the interaction of a CC-chemokine with CCR1, CCR3 and CCR5. |journal=Biochemistry |volume=36 |issue= 32 |pages= 9642–8 |year= 1997 |pmid= 9289016 |doi= 10.1021/bi970593z
*cite journal | author=Coulin F, Power CA, Alouani S, "et al." |title=Characterisation of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines. |journal=Eur. J. Biochem. |volume=248 |issue= 2 |pages= 507–15 |year= 1997 |pmid= 9346309 |doi=
*cite journal | author=Youn BS, Zhang SM, Broxmeyer HE, "et al." |title=Characterization of CKbeta8 and CKbeta8-1: two alternatively spliced forms of human beta-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1. |journal=Blood |volume=91 |issue= 9 |pages= 3118–26 |year= 1998 |pmid= 9558365 |doi=
*cite journal | author=Nardelli B, Tiffany HL, Bong GW, "et al." |title=Characterization of the signal transduction pathway activated in human monocytes and dendritic cells by MPIF-1, a specific ligand for CC chemokine receptor 1. |journal=J. Immunol. |volume=162 |issue= 1 |pages= 435–44 |year= 1999 |pmid= 9886417 |doi=
*cite journal | author=Shaw KT, Greig NH |title=Chemokine receptor mRNA expression at the in vitro blood-brain barrier during HIV infection. |journal=Neuroreport |volume=10 |issue= 1 |pages= 53–6 |year= 1999 |pmid= 10094132 |doi=
*cite journal | author=Zhang S, Youn BS, Gao JL, "et al." |title=Differential effects of leukotactin-1 and macrophage inflammatory protein-1 alpha on neutrophils mediated by CCR1. |journal=J. Immunol. |volume=162 |issue= 8 |pages= 4938–42 |year= 1999 |pmid= 10202040 |doi=
*cite journal | author=Lalani AS, Masters J, Zeng W, "et al." |title=Use of chemokine receptors by poxviruses. |journal=Science |volume=286 |issue= 5446 |pages= 1968–71 |year= 1999 |pmid= 10583963 |doi=

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