- CCL7
Chemokine (C-C motif) ligand 7 (CCL7) is a small
cytokine known as achemokine that was previously called monocyte-specific chemokine 3 (MCP3). Due to CCL7 possessing two adjacent N-terminalcysteine residues in its mature protein, it is classified among the subfamily of chemokines known as CC chemokines. CCL7 specifically attractsmonocyte s, and regulatesmacrophage function. It is produced by certaintumor cell lines and by macrophages.cite journal | author = Opdenakker G, Froyen G, Fiten P, Proost P, Van Damme J | title = Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines | journal = Biochem. Biophys. Res. Commun. | volume = 191 | issue = 2 | pages = 535–42 | year = 1993 | pmid = 8461011 | doi = 10.1006/bbrc.1993.1251 | issn = ] This chemokine is located onchromosome 17 in humans, in a large cluster containing many other CC chemokinescite journal | author = Opdenakker G, Fiten P, Nys G, Froyen G, Van Roy N, Speleman F, Laureys G, Van Damme J | title = The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12 | journal = Genomics | volume = 21 | issue = 2 | pages = 403–8 | year = 1994 | pmid = 7916328 | doi = 10.1006/geno.1994.1283 | issn = ] and is most closely related toCCL2 (previously called MCP1).References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Menten P, Wuyts A, Van Damme J |title=Monocyte chemotactic protein-3. |journal=Eur. Cytokine Netw. |volume=12 |issue= 4 |pages= 554–60 |year= 2002 |pmid= 11781181 |doi=
*cite journal | author=Van Damme J, Proost P, Lenaerts JP, Opdenakker G |title=Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family. |journal=J. Exp. Med. |volume=176 |issue= 1 |pages= 59–65 |year= 1992 |pmid= 1613466 |doi=
*cite journal | author=Ben-Baruch A, Xu L, Young PR, "et al." |title=Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3. |journal=J. Biol. Chem. |volume=270 |issue= 38 |pages= 22123–8 |year= 1995 |pmid= 7545673 |doi=
*cite journal | author=Opdenakker G, Fiten P, Nys G, "et al." |title=The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12. |journal=Genomics |volume=21 |issue= 2 |pages= 403–8 |year= 1994 |pmid= 7916328 |doi= 10.1006/geno.1994.1283
*cite journal | author=Minty A, Chalon P, Guillemot JC, "et al." |title=Molecular cloning of the MCP-3 chemokine gene and regulation of its expression. |journal=Eur. Cytokine Netw. |volume=4 |issue= 2 |pages= 99–110 |year= 1993 |pmid= 8318676 |doi=
*cite journal | author=Opdenakker G, Froyen G, Fiten P, "et al." |title=Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines. |journal=Biochem. Biophys. Res. Commun. |volume=191 |issue= 2 |pages= 535–42 |year= 1993 |pmid= 8461011 |doi=
*cite journal | author=Combadiere C, Ahuja SK, Van Damme J, "et al." |title=Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2B. |journal=J. Biol. Chem. |volume=270 |issue= 50 |pages= 29671–5 |year= 1996 |pmid= 8530354 |doi=
*cite journal | author=Power CA, Clemetson JM, Clemetson KJ, Wells TN |title=Chemokine and chemokine receptor mRNA expression in human platelets. |journal=Cytokine |volume=7 |issue= 6 |pages= 479–82 |year= 1996 |pmid= 8580362 |doi= 10.1006/cyto.1995.0065
*cite journal | author=Daugherty BL, Siciliano SJ, DeMartino JA, "et al." |title=Cloning, expression, and characterization of the human eosinophil eotaxin receptor. |journal=J. Exp. Med. |volume=183 |issue= 5 |pages= 2349–54 |year= 1996 |pmid= 8642344 |doi=
*cite journal | author=Kim KS, Rajarathnam K, Clark-Lewis I, Sykes BD |title=Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3. |journal=FEBS Lett. |volume=395 |issue= 2-3 |pages= 277–82 |year= 1996 |pmid= 8898111 |doi=
*cite journal | author=Meunier S, Bernassau JM, Guillemot JC, "et al." |title=Determination of the three-dimensional structure of CC chemokine monocyte chemoattractant protein 3 by 1H two-dimensional NMR spectroscopy. |journal=Biochemistry |volume=36 |issue= 15 |pages= 4412–22 |year= 1997 |pmid= 9109648 |doi= 10.1021/bi9627929
*cite journal | author=Polentarutti N, Introna M, Sozzani S, "et al." |title=Expression of monocyte chemotactic protein-3 in human monocytes and endothelial cells. |journal=Eur. Cytokine Netw. |volume=8 |issue= 3 |pages= 271–4 |year= 1997 |pmid= 9346360 |doi=
*cite journal | author=Bonini JA, Martin SK, Dralyuk F, "et al." |title=Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3. |journal=DNA Cell Biol. |volume=16 |issue= 10 |pages= 1249–56 |year= 1997 |pmid= 9364936 |doi=
*cite journal | author=Nibbs RJ, Wylie SM, Yang J, "et al." |title=Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6. |journal=J. Biol. Chem. |volume=272 |issue= 51 |pages= 32078–83 |year= 1998 |pmid= 9405404 |doi=
*cite journal | author=Wang JM, Ueda H, Howard OM, "et al." |title=HIV-1 envelope gp120 inhibits the monocyte response to chemokines through CD4 signal-dependent chemokine receptor down-regulation. |journal=J. Immunol. |volume=161 |issue= 8 |pages= 4309–17 |year= 1998 |pmid= 9780207 |doi=
*cite journal | author=Albini A, Ferrini S, Benelli R, "et al." |title=HIV-1 Tat protein mimicry of chemokines. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 22 |pages= 13153–8 |year= 1998 |pmid= 9789057 |doi=
*cite journal | author=Rabin RL, Park MK, Liao F, "et al." |title=Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling. |journal=J. Immunol. |volume=162 |issue= 7 |pages= 3840–50 |year= 1999 |pmid= 10201901 |doi=
*cite journal | author=Wedemeyer J, Lorentz A, Göke M, "et al." |title=Enhanced production of monocyte chemotactic protein 3 in inflammatory bowel disease mucosa. |journal=Gut |volume=44 |issue= 5 |pages= 629–35 |year= 1999 |pmid= 10205198 |doi=
*cite journal | author=Blanpain C, Migeotte I, Lee B, "et al." |title=CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist. |journal=Blood |volume=94 |issue= 6 |pages= 1899–905 |year= 1999 |pmid= 10477718 |doi=
*cite journal | author=Jordan NJ, Kolios G, Abbot SE, "et al." |title=Expression of functional CXCR4 chemokine receptors on human colonic epithelial cells. |journal=J. Clin. Invest. |volume=104 |issue= 8 |pages= 1061–9 |year= 1999 |pmid= 10525044 |doi=PBB_Controls
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