CCL3

For the aerodrome using the TC LID, CCL3, see Christina Lake Aerodrome.

Chemokine (C-C motif) ligand 3
PDB rendering based on 1b50.
Available structures PDB 1B50, 1B53, 2X69, 2X6G, 3FPU, 3H44, 3KBX
Identifiers
Symbols	CCL3; G0S19-1; LD78ALPHA; MIP-1-alpha; MIP1A; SCYA3
External IDs	OMIM: 182283 HomoloGene: 88430 GeneCards: CCL3 Gene
Gene Ontology Molecular function • signal transducer activity • chemokine activity • chemoattractant activity Cellular component • extracellular region • extracellular space • soluble fraction Biological process • cellular calcium ion homeostasis • exocytosis • cellular component movement • chemotaxis • inflammatory response • immune response • cytoskeleton organization • signal transduction • G-protein coupled receptor protein signaling pathway • cell-cell signaling • regulation of viral genome replication • positive chemotaxis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6348	n/a
Ensembl	ENSG00000006075	n/a
UniProt	P10147	n/a
RefSeq (mRNA)	NM_002983.2	n/a
RefSeq (protein)	NP_002974.1	n/a
Location (UCSC)	Chr 17: 34.42 – 34.42 Mb	n/a
PubMed search	[1]	n/a

Chemokine (C-C motif) ligand 3 (CCL3) is a protein that in humans is encoded by the CCL3 gene.

CCL3, also known as Macrophage inflammatory protein-1α (MIP-1α), is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes (Wolpe et al., 1988). Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha and beta.[supplied by OMIM]^[1]

Interactions

CCL3 has been shown to interact with CCL4.^[2]

See also

• Macrophage inflammatory proteins

References

1. ^ "Entrez Gene: CCL3 chemokine (C-C motif) ligand 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6348. 
2. ^ Guan, E; Wang J, Norcross M A (Apr. 2001). "Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer". J. Biol. Chem. (United States) 276 (15): 12404–9. doi:10.1074/jbc.M006327200. ISSN 0021-9258. PMID 11278300. 

Further reading

• Menten P, Wuyts A, Van Damme J (2003). "Macrophage inflammatory protein-1.". Cytokine Growth Factor Rev. 13 (6): 455–81. doi:10.1016/S1359-6101(02)00045-X. PMID 12401480. 
• Muthumani K, Desai BM, Hwang DS, et al. (2004). "HIV-1 Vpr and anti-inflammatory activity.". DNA Cell Biol. 23 (4): 239–47. doi:10.1089/104454904773819824. PMID 15142381. 
• Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection.". Curr. HIV Res. 3 (1): 87–94. doi:10.2174/1570162052773013. PMID 15638726. 
• Zhao RY, Elder RT (2005). "Viral infections and cell cycle G2/M regulation.". Cell Res. 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175. 
• Zhao RY, Bukrinsky M, Elder RT (2005). "HIV-1 viral protein R (Vpr) & host cellular responses.". Indian J. Med. Res. 121 (4): 270–86. PMID 15817944. 
• Li L, Li HS, Pauza CD, et al. (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions.". Cell Res. 15 (11–12): 923–34. doi:10.1038/sj.cr.7290370. PMID 16354571.