- CXCL9
Chemokine (C-X-C motif) ligand 9 (CXCL9) is a small
cytokine belonging to the CXCchemokine family that is also known as Monokine induced by gamma interferon (MIG). CXCL9 is a T-cellchemoattractant , which is induced by IFN-γ. It is closely related to two other CXC chemokines calledCXCL10 andCXCL11 , whose genes are located near thegene for CXCL9 on humanchromosome 4 .cite journal | author = Lee HH, Farber JM | title = Localization of the gene for the human MIG cytokine on chromosome 4q21 adjacent to INP10 reveals a chemokine "mini-cluster" | journal = Cytogenet. Cell Genet. | volume = 74 | issue = 4 | pages = 255–8 | year = 1996 | pmid = 8976378 | doi = | issn = ] cite journal | author = O'Donovan N, Galvin M, Morgan JG | title = Physical mapping of the CXC chemokine locus on human chromosome 4 | journal = Cytogenet. Cell Genet. | volume = 84 | issue = 1-2 | pages = 39–42 | year = 1999 | pmid = 10343098 | doi = | issn = ] CXCL9, CXCL10 and CXCL11 all elicit their chemotactic functions by interacting with thechemokine receptor CXCR3.cite journal | author = Tensen CP, Flier J, Van Der Raaij-Helmer EM, Sampat-Sardjoepersad S, Van Der Schors RC, Leurs R, Scheper RJ, Boorsma DM, Willemze R | title = Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3) | journal = J. Invest. Dermatol. | volume = 112 | issue = 5 | pages = 716–22 | year = 1999 | pmid = 10233762 | doi = 10.1046/j.1523-1747.1999.00581.x | issn = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Farber JM |title=A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 14 |pages= 5238–42 |year= 1990 |pmid= 2115167 |doi=
*cite journal | author=Liao F, Rabin RL, Yannelli JR, "et al." |title=Human Mig chemokine: biochemical and functional characterization. |journal=J. Exp. Med. |volume=182 |issue= 5 |pages= 1301–14 |year= 1995 |pmid= 7595201 |doi=
*cite journal | author=Farber JM |title=HuMig: a new human member of the chemokine family of cytokines. |journal=Biochem. Biophys. Res. Commun. |volume=192 |issue= 1 |pages= 223–30 |year= 1993 |pmid= 8476424 |doi= 10.1006/bbrc.1993.1403
*cite journal | author=Lee HH, Farber JM |title=Localization of the gene for the human MIG cytokine on chromosome 4q21 adjacent to INP10 reveals a chemokine "mini-cluster". |journal=Cytogenet. Cell Genet. |volume=74 |issue= 4 |pages= 255–8 |year= 1997 |pmid= 8976378 |doi=
*cite journal | author=Weng Y, Siciliano SJ, Waldburger KE, "et al." |title=Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. |journal=J. Biol. Chem. |volume=273 |issue= 29 |pages= 18288–91 |year= 1998 |pmid= 9660793 |doi=
*cite journal | author=Erdel M, Laich A, Utermann G, "et al." |title=The human gene encoding SCYB9B, a putative novel CXC chemokine, maps to human chromosome 4q21 like the closely related genes for MIG (SCYB9) and INP10 (SCYB10). |journal=Cytogenet. Cell Genet. |volume=81 |issue= 3-4 |pages= 271–2 |year= 1998 |pmid= 9730616 |doi=
*cite journal | author=Jenh CH, Cox MA, Kaminski H, "et al." |title=Cutting edge: species specificity of the CC chemokine 6Ckine signaling through the CXC chemokine receptor CXCR3: human 6Ckine is not a ligand for the human or mouse CXCR3 receptors. |journal=J. Immunol. |volume=162 |issue= 7 |pages= 3765–9 |year= 1999 |pmid= 10201891 |doi=
*cite journal | author=Rabin RL, Park MK, Liao F, "et al." |title=Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling. |journal=J. Immunol. |volume=162 |issue= 7 |pages= 3840–50 |year= 1999 |pmid= 10201901 |doi=
*cite journal | author=Tensen CP, Flier J, Van Der Raaij-Helmer EM, "et al." |title=Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3). |journal=J. Invest. Dermatol. |volume=112 |issue= 5 |pages= 716–22 |year= 1999 |pmid= 10233762 |doi= 10.1046/j.1523-1747.1999.00581.x
*cite journal | author=Shields PL, Morland CM, Salmon M, "et al." |title=Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver. |journal=J. Immunol. |volume=163 |issue= 11 |pages= 6236–43 |year= 1999 |pmid= 10570316 |doi=
*cite journal | author=Jinquan T, Jing C, Jacobi HH, "et al." |title=CXCR3 expression and activation of eosinophils: role of IFN-gamma-inducible protein-10 and monokine induced by IFN-gamma. |journal=J. Immunol. |volume=165 |issue= 3 |pages= 1548–56 |year= 2000 |pmid= 10903763 |doi=
*cite journal | author=Loetscher P, Pellegrino A, Gong JH, "et al." |title=The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3. |journal=J. Biol. Chem. |volume=276 |issue= 5 |pages= 2986–91 |year= 2001 |pmid= 11110785 |doi= 10.1074/jbc.M005652200
*cite journal | author=Romagnani P, Annunziato F, Lazzeri E, "et al." |title=Interferon-inducible protein 10, monokine induced by interferon gamma, and interferon-inducible T-cell alpha chemoattractant are produced by thymic epithelial cells and attract T-cell receptor (TCR) alphabeta+ CD8+ single-positive T cells, TCRgammadelta+ T cells, and natural killer-type cells in human thymus. |journal=Blood |volume=97 |issue= 3 |pages= 601–7 |year= 2001 |pmid= 11157474 |doi=
*cite journal | author=Dwinell MB, Lügering N, Eckmann L, Kagnoff MF |title=Regulated production of interferon-inducible T-cell chemoattractants by human intestinal epithelial cells. |journal=Gastroenterology |volume=120 |issue= 1 |pages= 49–59 |year= 2001 |pmid= 11208713 |doi=
*cite journal | author=Lambeir AM, Proost P, Durinx C, "et al." |title=Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family. |journal=J. Biol. Chem. |volume=276 |issue= 32 |pages= 29839–45 |year= 2001 |pmid= 11390394 |doi= 10.1074/jbc.M103106200
*cite journal | author=Stoof TJ, Flier J, Sampat S, "et al." |title=The antipsoriatic drug dimethylfumarate strongly suppresses chemokine production in human keratinocytes and peripheral blood mononuclear cells. |journal=Br. J. Dermatol. |volume=144 |issue= 6 |pages= 1114–20 |year= 2001 |pmid= 11422029 |doi=
*cite journal | author=Campbell JD, Stinson MJ, Simons FE, "et al." |title=In vivo stability of human chemokine and chemokine receptor expression. |journal=Hum. Immunol. |volume=62 |issue= 7 |pages= 668–78 |year= 2001 |pmid= 11423172 |doi=
*cite journal | author=Scapini P, Laudanna C, Pinardi C, "et al." |title=Neutrophils produce biologically active macrophage inflammatory protein-3alpha (MIP-3alpha)/CCL20 and MIP-3beta/CCL19. |journal=Eur. J. Immunol. |volume=31 |issue= 7 |pages= 1981–8 |year= 2001 |pmid= 11449350 |doi=
*cite journal | author=Gillitzer R |title=Inflammation in human skin: a model to study chemokine-mediated leukocyte migration in vivo. |journal=J. Pathol. |volume=194 |issue= 4 |pages= 393–4 |year= 2001 |pmid= 11523044 |doi= 10.1002/1096-9896(200108)194:4<393::AID-PATH907>3.0.CO;2-7 |doilabel=10.1002/1096-9896(200108)194:4393::AID-PATH9073.0.CO;2-7
*cite journal | author=Romagnani P, Rotondi M, Lazzeri E, "et al." |title=Expression of IP-10/CXCL10 and MIG/CXCL9 in the thyroid and increased levels of IP-10/CXCL10 in the serum of patients with recent-onset Graves' disease. |journal=Am. J. Pathol. |volume=161 |issue= 1 |pages= 195–206 |year= 2002 |pmid= 12107104 |doi=PBB_Controls
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