CCL12

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Name = chemokine (C-C motif) ligand 12
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Symbol = CCL12
AltSymbols = SCYA12
EntrezGene = 20293
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RefSeq = NM_011331
UniProt = Q62401
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Chemokine (C-C motif) ligand 12 (CCL12) is a small cytokine belonging to the CC chemokine family that has been described in mice. It is also known as "monocyte chemotactic protein 5" (MCP-5) and, due to its similarity with the human chemokine MCP-1, sometimes it is called "MCP-1-related chemokine". CCL12 specifically attracts eosinophils, monocytes and lymphocytes.cite journal |author=Jia G, Gonzalo J, Lloyd C, Kremer L, Lu L, Martinez-A C, Wershil B, Gutierrez-Ramos J |title=Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation |journal=J Exp Med |volume=184 |issue=5 |pages=1939–51 |year=1996 |pmid=8920881 |doi=10.1084/jem.184.5.1939] This chemokine is found predomiantly in lymph nodes and thymus under normal conditions, and its expression can be hugely induced in macrophages.cite journal |author=Sarafi M, Garcia-Zepeda E, MacLean J, Charo I, Luster A |title=Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1 |journal=J Exp Med |volume=185 |issue=1 |pages=99–109 |year=1997 |pmid=8996246 |doi=10.1084/jem.185.1.99] It is thought to coordinate cell movements during early allergic reactions, and immune response to pathogens. The gene for CCL12 is found in a cluster of CC chemokines on mouse chromosome 11.

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