CCL9

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Name = chemokine (C-C motif) ligand 9
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Symbol = CCL9
AltSymbols = SCYB9, CCL10, MIP-1gamma, CCF18, MRP-2
EntrezGene = 20308
OMIM =
RefSeq = NM_011338
UniProt = P51670
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Chemokine (C-C motif) ligand 9 (CCL9) is a small cytokine belonging to the CC chemokine family, also called "macrophage inflammatory protein-1 gamma" (MIP-1γ), "macrophage inflammatory protein-related protein-2" (MRP-2) and CCF18 , that has been described in rodents. CCL9 has also been previously designated CCL10, although this name is no longer in use. It is secreted by follicle-associated epithelium (FAE) such as that found around Peyer's patches, and attracts dendritic cells that possess the cell surface molecule CD11b and the chemokine receptor CCR1. [cite journal |author=Zhao X, Sato A, Dela Cruz C, Linehan M, Luegering A, Kucharzik T, Shirakawa A, Marquez G, Farber J, Williams I, Iwasaki A |title=CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells |journal=J Immunol |volume=171 |issue=6 |pages=2797–803 |year=2003 |pmid=12960300] CCL9 can activate osteoclasts through its receptor CCR1 (the most abundant chemokine receptor found on osteoclasts) suggesting an important role for CCL9 in bone resorption. [cite journal |author=Lean J, Murphy C, Fuller K, Chambers T |title=CCL9/MIP-1gamma and its receptor CCR1 are the major chemokine ligand/receptor species expressed by osteoclasts |journal=J Cell Biochem |volume=87 |issue=4 |pages=386–93 |year=2002 |pmid=12397598 |doi=10.1002/jcb.10319] CCL9 is constitutively expressed in macrophages and myeloid cells. [cite journal |author=Youn B, Jang I, Broxmeyer H, Cooper S, Jenkins N, Gilbert D, Copeland N, Elick T, Fraser M, Kwon B |title=A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors |journal=J Immunol |volume=155 |issue=5 |pages=2661–7 |year=1995 |pmid=7650394] cite journal |author=Hara T, Bacon K, Cho L, Yoshimura A, Morikawa Y, Copeland N, Gilbert D, Jenkins N, Schall T, Miyajima A |title=Molecular cloning and functional characterization of a novel member of the C-C chemokine family |journal=J Immunol |volume=155 |issue=11 |pages=5352–8 |year=1995 |pmid=7594550] The gene for CCL9 is located on chromosome 11 in mice.

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