Interleukin 19

protein
Name = Interleukin 19
caption = Crystal structure of human IL-19

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width = 250 px
HGNCid = 5990
Symbol = IL19
AltSymbols = , MDA1, ZMDA1, IL-10C
EntrezGene = 29949
OMIM = 605687
RefSeq = NM_153758
UniProt = Q9UHD0
PDB = 1N1F
ECnumber =
Chromosome = 1
Arm = q
Band = 32.2
LocusSupplementaryData =

Interleukin-19 is a cytokine that belongs to the IL-10 family of cytokines along with several other interleukins including IL-10, IL-20, IL-22, IL-24, IL-26, and several virus-encoded cytokines. It signals through the same cell surface receptor (IL-20R) that is used by IL-20 and IL-24. The IL-19 gene is expressed in resting monocytes and B cells. It is up-regulated in monocytes following stimulation with granulocyte-macrophage colony-stimulating factor (GM-CSF) or lipopolysaccharide. [Chang, C. et al., Crystal Structure of Interleukin-19 Defines a New Subfamily of Helical Cytokines. Journal of Biological Chemistry, 2003, Volume 278, pages 3308-3313.]

References