Interleukin 26

protein
Name = Interleukin 26
caption =


width =
HGNCid = 17119
Symbol = IL26
AltSymbols = , AK155
EntrezGene = 55801
OMIM = 605679
RefSeq = NM_018402
UniProt = Q9NPH9
PDB =
ECnumber =
Chromosome = 12
Arm = q
Band = 15
LocusSupplementaryData =

Interleukin-26 (IL-26) is a 171-amino acid protein, which is similar in amino acid sequence to interleukin 10. It was originally called AK155 and is composed of a signal sequence, 6 helices, and 4 conserved cysteine residues. IL-26 is expressed in certain herpesvirus-transformed T cells but not in primary stimulated T cells. [A. Knappe, et al., Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with herpesvirus saimiri. Journal of Virolology, 2000, Volume 74, pages 3881-3887.] IL-26 signals through a receptor complex comprising two distinct proteins called IL-20 receptor 1 and IL-10 receptor 2. [F. Sheikh, et al., IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2. Journal of Immunology, 2004, Volume 172, pages 2006-2010.] By signaling through this receptor complex, IL-26 induces rapid phosphorylation of the transcription factors STAT1 and STAT3, which enhance IL-10 and IL-8 secretion and as expression of the CD54 molecule on the surface of epithelial cells. [cite journal |author=Hör S, Pirzer H, Dumoutier L, Bauer F, Wittmann S, Sticht H, Renauld J, de Waal Malefyt R, Fickenscher H |title=The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains |journal=J Biol Chem |volume=279 |issue=32 |pages=33343–51 |year=2004 |pmid=15178681 |doi=10.1074/jbc.M405000200]

References