Interleukin 24

Interleukin 24 (IL-24) is a cytokine belonging to the IL-10 family of cytokines that signals through two heterodimeric receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2. This interleukin is also known as Melanoma differentiation-associated 7 (mda-7) due to its discovery as a tumour suppressing protein. IL-24 appears to control in cell survival and proliferation by inducing rapid activation of particular transcription factors called Stat-1 and Stat-3. This cytokine is predominantly released by activated monocytes, macrophages and T helper 2 (Th2) cells [Poindexter et al., Cytokine induction of interleukin-24 in human peripheral blood mononuclear cells. Journal of Leukocyte Biology 2005, Volume 78, pages 745-752.] and acts on non-haematopoietic tissues such as skin, lung and reproductive tissues. IL-24 performs important roles in wound healing, psoriasis and cancer. [Wang M, Liang P. Interleukin-24 and its receptors. Immunology, 2005, Volume 114, pages 166-70.] Several studies have shown that cell death occurs in cancer cells/cell lines following exposure to IL-24. [Fisher PB, et al., mda-7/IL-24, a novel cancer selective apoptosis inducing cytokine gene: from the laboratory into the clinic. Cancer Biology and Therapeutics. 2003, Volume 2, pages S23-37.] [M. Sauane et al., Melanoma Differentiation Associated Gene-7/Interleukin-24 Promotes Tumor Cell-Specific Apoptosis through Both Secretory and Nonsecretory Pathways. Cancer Research, 2004, Volume 64, pages 2988-2993.] The gene for IL-24 is located on chromosome 1 in humans. [ [http://www.genecards.org/cgi-bin/carddisp.pl?gene=IL24 IL24 GeneCard ] ]

References

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = no