Macrophage inflammatory protein
- Macrophage inflammatory protein
protein
Name = chemokine (C-C motif) ligand 3
caption =
width =
HGNCid = 10627
Symbol = CCL3
AltSymbols = SCYA3, MIP-1α
EntrezGene = 6348
OMIM = 182283
RefSeq = NM_002983
UniProt = P10147
PDB = 1B50
ECnumber =
Chromosome = 17
Arm = q
Band = 12
LocusSupplementaryData =
protein
Name = chemokine (C-C motif) ligand 4
caption =
width =
HGNCid = 10630
Symbol = CCL4
AltSymbols = SCYA4, MIP-1β, LAG1
EntrezGene = 6351
OMIM = 182284
RefSeq = NM_002984
UniProt = P13236
PDB = 1HUM
ECnumber =
Chromosome = 17
Arm = q
Band = 21
LocusSupplementaryData = -q23
Macrophage Inflammatory Proteins (MIP) belong to the family of chemotactic cytokines known as chemokines. In humans, there are two major forms, MIP-1α and MIP-1β that are now officially named CCL3 and CCL4 respectively. Both are major factors produced by macrophages after they are stimulated with bacterial endotoxins. [Sherry et al. Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1-beta. J. Exp. Med. 168: 2251-2259, 1988. ] They activate human granulocytes (neutrophils, eosinophils and basophils) which can lead to acute neutrophilic inflammation. They also induce the synthesis and release of other pro-inflammatory cytokines such as interleukin 1 (IL-1), IL-6 and TNF-α from fibroblasts and macrophages. The genes for CCL3 and CCL4 are both located on human chromosome 17. [Irving et al. Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q. Nucleic Acids Res. 18: 3261-3270, 1990. ]
References
ee also
* chemokine
External links
*
Wikimedia Foundation.
2010.
Look at other dictionaries:
macrophage inflammatory protein 1 — (= MIP1) Cytokine now recognized to exist in two forms, MIP1 a and MIP1 b (SIS a, TY 5, L2G25B, 464.1, GOS 19 1). Small cytokine (monokine) with inflammatory and chemokinetic properties … Dictionary of molecular biology
macrophage inflammatory protein 2 — (= MIP2) Cytokine that is chemotactic for neutrophils … Dictionary of molecular biology
Protein — A large molecule composed of one or more chains of amino acids in a specific order determined by the base sequence of nucleotides in the DNA coding for the protein. Proteins are required for the structure, function, and regulation of the body s… … Medical dictionary
Macrophage migration inhibitory factor — (glycosylation inhibiting factor) PDB rendering based on 1ca7 … Wikipedia
Macrophage — A macrophage of a mouse stretching its arms (pseudopodia) to engulf two particles, possibly pathogens. Trypan Blue Exclusion. Latin macrophagocytus … Wikipedia
Alveolar macrophage — Micrograph showing hemosiderin laden alveolar marcophages, as seen in a pulmonary haemorrhage. H E stain. An alveolar macrophage (or dust cell) is a type of macrophage found in the pulmonary alveolus, near the pneumocytes, but separated from the… … Wikipedia
Granulocyte macrophage colony-stimulating factor — Not to be confused with granulocyte colony stimulating factor. Colony stimulating factor 2 (granulocyte macrophage) PDB rendering based on 2gmf … Wikipedia
C-reactive protein — C reactive protein, pentraxin related Constructed from 1B09 … Wikipedia
Nuclear receptor related 1 protein — Nuclear receptor subfamily 4, group A, member 2 PDB rendering based on 1cit … Wikipedia
CD40 (protein) — CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. PBB Summary… … Wikipedia
