Interleukin 18

Interleukin-18 (IL-18) is a cytokine produced by macrophages and other cells that belongs to the IL-1 superfamily. IL-18 works together with IL-12 to induce cell-mediated immunity following infection with microbial products like lipopolysaccharide (LPS). After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon-γ (IFN-γ) or type II interferon that plays an important role in activating the macrophages or other cells. Apart from its physiological role, IL-18 is also able to induce severe inflammatory reactions, which suggests its role in certain inflammatory disorders. PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. [cite web | title = Entrez Gene: IL18 interleukin 18 (interferon-gamma-inducing factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3606| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Biet F, Locht C, Kremer L |title=Immunoregulatory functions of interleukin 18 and its role in defense against bacterial pathogens. |journal=J. Mol. Med. |volume=80 |issue= 3 |pages= 147–62 |year= 2002 |pmid= 11894141 |doi= 10.1007/s00109-001-0307-1
*cite journal | author=Nakanishi K |title= [Regulation of Th1 and Th2 immune responses by IL-18] |journal=Kekkaku |volume=77 |issue= 2 |pages= 87–93 |year= 2002 |pmid= 11905033 |doi=
*cite journal | author=Reddy P, Ferrara JL |title=Role of interleukin-18 in acute graft-vs-host disease. |journal=J. Lab. Clin. Med. |volume=141 |issue= 6 |pages= 365–71 |year= 2003 |pmid= 12819633 |doi= 10.1016/S0022-2143(03)00028-3
*cite journal | author=Kanai T, Uraushihara K, Totsuka T, "et al." |title=Macrophage-derived IL-18 targeting for the treatment of Crohn's disease. |journal=Current drug targets. Inflammation and allergy |volume=2 |issue= 2 |pages= 131–6 |year= 2003 |pmid= 14561165 |doi=
*cite journal | author=Matsui K, Tsutsui H, Nakanishi K |title=Pathophysiological roles for IL-18 in inflammatory arthritis. |journal=Expert Opin. Ther. Targets |volume=7 |issue= 6 |pages= 701–24 |year= 2005 |pmid= 14640907 |doi= 10.1517/14728222.7.6.701
*cite journal | author=Yoshimoto T, Nakanishi K |title=Roles of IL-18 in basophils and mast cells. |journal=Allergology international : official journal of the Japanese Society of Allergology |volume=55 |issue= 2 |pages= 105–13 |year= 2006 |pmid= 17075246 |doi= 10.2332/allergolint.55.105
*cite journal | author=Orozco A, Gemmell E, Bickel M, Seymour GJ |title=Interleukin 18 and periodontal disease. |journal=J. Dent. Res. |volume=86 |issue= 7 |pages= 586–93 |year= 2007 |pmid= 17586702 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes