CCL22

Chemokine (C-C motif) ligand 22, also known as CCL22, is a human gene.cite web | title = Entrez Gene: CCL22 chemokine (C-C motif) ligand 22| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6367| accessdate = ]

The protein encoded by this gene is secreted by dendritic cells and macrophages, and elicits its effects on its target cells by interacting with cell surface chemokine receptors such as CCR4.cite journal | author = Vulcano M, Albanesi C, Stoppacciaro A, Bagnati R, D'Amico G, Struyf S, Transidico P, Bonecchi R, Del Prete A, Allavena P, Ruco LP, Chiabrando C, Girolomoni G, Mantovani A, Sozzani S | title = Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo | journal = Eur. J. Immunol. | volume = 31 | issue = 3 | pages = 812–22 | year = 2001 | pmid = 11241286 | doi = 10.1002/1521-4141(200103)31:3<812::AID-IMMU812>3.0.CO;2-L | issn = | doilabel = 10.1002/1521-4141(200103)31:3812::AID-IMMU8123.0.CO;2-L ] The gene for CCL22 is located in human chromosome 16 in a cluster with other chemokines called CX3CL1 and CCL17.cite journal | author = Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD | title = Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q | journal = Genomics | volume = 60 | issue = 3 | pages = 295–308 | year = 1999 | pmid = 10493829 | doi = 10.1006/geno.1999.5927 | issn = ] cite journal | author = Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O | title = Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13 | journal = Cytogenet. Cell Genet. | volume = 81 | issue = 1 | pages = 10–1 | year = 1998 | pmid = 9691168 | doi = 10.1159/000015000 | issn = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Robertson MJ |title=Role of chemokines in the biology of natural killer cells. |journal=J. Leukoc. Biol. |volume=71 |issue= 2 |pages= 173–83 |year= 2002 |pmid= 11818437 |doi=
*cite journal | author=Gear AR, Camerini D |title=Platelet chemokines and chemokine receptors: linking hemostasis, inflammation, and host defense. |journal=Microcirculation (New York, N.Y. : 1994) |volume=10 |issue= 3-4 |pages= 335–50 |year= 2003 |pmid= 12851650 |doi= 10.1038/sj.mn.7800198
*cite journal | author=Godiska R, Chantry D, Raport CJ, "et al." |title=Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells. |journal=J. Exp. Med. |volume=185 |issue= 9 |pages= 1595–604 |year= 1997 |pmid= 9151897 |doi=
*cite journal | author=Chang M, McNinch J, Elias C, "et al." |title=Molecular cloning and functional characterization of a novel CC chemokine, stimulated T cell chemotactic protein (STCP-1) that specifically acts on activated T lymphocytes. |journal=J. Biol. Chem. |volume=272 |issue= 40 |pages= 25229–37 |year= 1997 |pmid= 9312138 |doi=
*cite journal | author=Pal R, Garzino-Demo A, Markham PD, "et al." |title=Inhibition of HIV-1 infection by the beta-chemokine MDC. |journal=Science |volume=278 |issue= 5338 |pages= 695–8 |year= 1997 |pmid= 9381181 |doi=
*cite journal | author=Imai T, Chantry D, Raport CJ, "et al." |title=Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. |journal=J. Biol. Chem. |volume=273 |issue= 3 |pages= 1764–8 |year= 1998 |pmid= 9430724 |doi=
*cite journal | author=Nomiyama H, Imai T, Kusuda J, "et al." |title=Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13. |journal=Cytogenet. Cell Genet. |volume=81 |issue= 1 |pages= 10–1 |year= 1998 |pmid= 9691168 |doi=
*cite journal | author=Struyf S, Proost P, Sozzani S, "et al." |title=Enhanced anti-HIV-1 activity and altered chemotactic potency of NH2-terminally processed macrophage-derived chemokine (MDC) imply an additional MDC receptor. |journal=J. Immunol. |volume=161 |issue= 6 |pages= 2672–5 |year= 1998 |pmid= 9743322 |doi=
*cite journal | author=Meucci O, Fatatis A, Simen AA, "et al." |title=Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 24 |pages= 14500–5 |year= 1998 |pmid= 9826729 |doi=
*cite journal | author=Proost P, Struyf S, Schols D, "et al." |title=Truncation of macrophage-derived chemokine by CD26/ dipeptidyl-peptidase IV beyond its predicted cleavage site affects chemotactic activity and CC chemokine receptor 4 interaction. |journal=J. Biol. Chem. |volume=274 |issue= 7 |pages= 3988–93 |year= 1999 |pmid= 9933589 |doi=
*cite journal | author=Loftus BJ, Kim UJ, Sneddon VP, "et al." |title=Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. |journal=Genomics |volume=60 |issue= 3 |pages= 295–308 |year= 1999 |pmid= 10493829 |doi= 10.1006/geno.1999.5927
*cite journal | author=Annunziato F, Romagnani P, Cosmi L, "et al." |title=Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selection. |journal=J. Immunol. |volume=165 |issue= 1 |pages= 238–46 |year= 2000 |pmid= 10861057 |doi=
*cite journal | author=Vulcano M, Albanesi C, Stoppacciaro A, "et al." |title=Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo. |journal=Eur. J. Immunol. |volume=31 |issue= 3 |pages= 812–22 |year= 2001 |pmid= 11241286 |doi=
*cite journal | author=Berin MC, Dwinell MB, Eckmann L, Kagnoff MF |title=Production of MDC/CCL22 by human intestinal epithelial cells. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=280 |issue= 6 |pages= G1217–26 |year= 2001 |pmid= 11352815 |doi=
*cite journal | author=Lambeir AM, Proost P, Durinx C, "et al." |title=Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family. |journal=J. Biol. Chem. |volume=276 |issue= 32 |pages= 29839–45 |year= 2001 |pmid= 11390394 |doi= 10.1074/jbc.M103106200
*cite journal | author=Wakahara S, Fujii Y, Nakao T, "et al." |title=Gene expression profiles for Fc epsilon RI, cytokines and chemokines upon Fc epsilon RI activation in human cultured mast cells derived from peripheral blood. |journal=Cytokine |volume=16 |issue= 4 |pages= 143–52 |year= 2002 |pmid= 11792124 |doi= 10.1006/cyto.2001.0958
*cite journal | author=Ghia P, Strola G, Granziero L, "et al." |title=Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22. |journal=Eur. J. Immunol. |volume=32 |issue= 5 |pages= 1403–13 |year= 2002 |pmid= 11981828 |doi= 10.1002/1521-4141(200205)32:5&lt;1403::AID-IMMU1403&gt;3.0.CO;2-Y
*cite journal | author=D'Ambrosio D, Albanesi C, Lang R, "et al." |title=Quantitative differences in chemokine receptor engagement generate diversity in integrin-dependent lymphocyte adhesion. |journal=J. Immunol. |volume=169 |issue= 5 |pages= 2303–12 |year= 2002 |pmid= 12193695 |doi=
*cite journal | author=Campbell JD, Stinson MJ, Simons FE, HayGlass KT |title=Systemic chemokine and chemokine receptor responses are divergent in allergic versus non-allergic humans. |journal=Int. Immunol. |volume=14 |issue= 11 |pages= 1255–62 |year= 2003 |pmid= 12407016 |doi=

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