CXCL16

protein
Name = chemokine (C-X-C motif) ligand 16
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HGNCid = 16642
Symbol = CXCL16
AltSymbols = SCYB16, SR-PSOX, CXCLG16
EntrezGene = 58191
OMIM = 605398
RefSeq = NM_022059
UniProt = Q9H2A7
PDB =
ECnumber =
Chromosome = 17
Arm = p
Band = 13
LocusSupplementaryData =

Chemokine (C-X-C motif) ligand 16 (CXCL16) is a small cytokine belonging to the CXC chemokine family. Larger than other chemokines (with 254 amino acids), CXCL16 is composed of a CXC chemokine domain, a mucin-like stalk, a transmembrane domain and a cytoplasmic tail containing a potential tyrosine phosphorylation site that may bind SH2.cite journal |author=Matloubian M, David A, Engel S, Ryan J, Cyster J |title=A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo |journal=Nat Immunol |volume=1 |issue=4 |pages=298–304 |year=2000 |pmid=11017100 |doi=10.1038/79738] These are unusual features for a chemokine, and allow CXCL16 to be expressed as a cell surface bound molecule, as well as a soluble chemokine.cite journal |author=Abel S, Hundhausen C, Mentlein R, Schulte A, Berkhout T, Broadway N, Hartmann D, Sedlacek R, Dietrich S, Muetze B, Schuster B, Kallen K, Saftig P, Rose-John S, Ludwig A |title=The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10 |journal=J Immunol |volume=172 |issue=10 |pages=6362–72 |year=2004 |pmid=15128827] CXCL16 is produced by dendritic cells found in the T cell zones of lymphoid organs, and by cells found in the red pulp of the spleen. Cells that bind and migrate in response to CXCL16 include several subsets of T cells, and natural killer T (NKT) cells. CXCL16 interacts with the chemokine receptor CXCR6, also known as Bonzo. [cite journal |author=Wilbanks A, Zondlo S, Murphy K, Mak S, Soler D, Langdon P, Andrew D, Wu L, Briskin M |title=Expression cloning of the STRL33/BONZO/TYMSTRligand reveals elements of CC, CXC, and CX3C chemokines |journal=J Immunol |volume=166 |issue=8 |pages=5145–54 |year=2001 |pmid=11290797] Expression of CXCL16 is induced by the inflammatory cytokines IFN-gamma and TNF-alpha. The gene for human CXCL16 is located on chromosome 17.

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