CCL11

Chemokine (C-C motif) ligand 11 (CCL11) is a small cytokine belonging to the CC chemokine family that is also known as eotaxin-1. CCL11 selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses.cite journal | author = Ponath PD, Qin S, Ringler DJ, Clark-Lewis I, Wang J, Kassam N, Smith H, Shi X, Gonzalo JA, Newman W, Gutierrez-Ramos JC, Mackay CR | title = Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils | journal = J. Clin. Invest. | volume = 97 | issue = 3 | pages = 604–12 | year = 1996 | pmid = 8609214 | doi = | issn = | url = http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=8609214 ] cite journal | author = Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD | title = Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia | journal = Nat. Med. | volume = 2 | issue = 4 | pages = 449–56 | year = 1996 | pmid = 8597956 | doi = | issn = ] cite journal | author = Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD | title = Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia | journal = Nat. Med. | volume = 2 | issue = 4 | pages = 449–56 | year = 1996 | pmid = 8597956 | doi = 10.1038/nm0496-449 | issn = ] The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which CCL11 is a ligand include CCR2,cite journal | author = Ogilvie P, Bardi G, Clark-Lewis I, Baggiolini M, Uguccioni M | title = Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5 | journal = Blood | volume = 97 | issue = 7 | pages = 1920–4 | year = 2001 | pmid = 11264152 | doi = 10.1182/blood.V97.7.1920 | issn = ] CCR3cite journal | author = Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, Tiffany HL, Murphy PM, Yoshie O | title = Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3 | journal = J. Biol. Chem. | volume = 271 | issue = 13 | pages = 7725–30 | year = 1996 | pmid = 8631813 | doi = 10.1074/jbc.271.13.7725 | issn = ] and CCR5. However, it has been found that eotaxin-1 (CCL11) has high degree selectivity for its receptor, such that they are inactive on neutrophils and monocytes, which do not express CCR3.cite journal | author = Baggiolini M, Dewald B, Moser B | title = Human chemokines: an update | journal = Annu. Rev. Immunol. | volume = 15 | issue = | pages = 675–705 | year = 1997 | pmid = 9143704 | doi = 10.1146/annurev.immunol.15.1.675 | issn = ] The gene for human CCL11 ("scya11") is encoded on three exons and is located on chromosome 17.cite journal | author = Hein H, Schlüter C, Kulke R, Christophers E, Schröder JM, Bartels J | title = Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene | journal = Biochem. Biophys. Res. Commun. | volume = 237 | issue = 3 | pages = 537–42 | year = 1997 | pmid = 9299399 | doi = 10.1006/bbrc.1997.7169 | issn = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, "et al." |title=Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia. |journal=Nat. Med. |volume=2 |issue= 4 |pages= 449–56 |year= 1996 |pmid= 8597956 |doi=
*cite journal | author=Ponath PD, Qin S, Ringler DJ, "et al." |title=Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils. |journal=J. Clin. Invest. |volume=97 |issue= 3 |pages= 604–12 |year= 1996 |pmid= 8609214 |doi=
*cite journal | author=Kitaura M, Nakajima T, Imai T, "et al." |title=Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3. |journal=J. Biol. Chem. |volume=271 |issue= 13 |pages= 7725–30 |year= 1996 |pmid= 8631813 |doi=
*cite journal | author=Daugherty BL, Siciliano SJ, DeMartino JA, "et al." |title=Cloning, expression, and characterization of the human eosinophil eotaxin receptor. |journal=J. Exp. Med. |volume=183 |issue= 5 |pages= 2349–54 |year= 1996 |pmid= 8642344 |doi=
*cite journal | author=Choe H, Farzan M, Sun Y, "et al." |title=The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. |journal=Cell |volume=85 |issue= 7 |pages= 1135–48 |year= 1996 |pmid= 8674119 |doi=
*cite journal | author=Ponath PD, Qin S, Post TW, "et al." |title=Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. |journal=J. Exp. Med. |volume=183 |issue= 6 |pages= 2437–48 |year= 1996 |pmid= 8676064 |doi=
*cite journal | author=Bartels J, Schlüter C, Richter E, "et al." |title=Human dermal fibroblasts express eotaxin: molecular cloning, mRNA expression, and identification of eotaxin sequence variants. |journal=Biochem. Biophys. Res. Commun. |volume=225 |issue= 3 |pages= 1045–51 |year= 1996 |pmid= 8780731 |doi= 10.1006/bbrc.1996.1292
*cite journal | author=Garcia-Zepeda EA, Rothenberg ME, Weremowicz S, "et al." |title=Genomic organization, complete sequence, and chromosomal location of the gene for human eotaxin (SCYA11), an eosinophil-specific CC chemokine. |journal=Genomics |volume=41 |issue= 3 |pages= 471–6 |year= 1997 |pmid= 9169149 |doi= 10.1006/geno.1997.4656
*cite journal | author=Hein H, Schlüter C, Kulke R, "et al." |title=Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene. |journal=Biochem. Biophys. Res. Commun. |volume=237 |issue= 3 |pages= 537–42 |year= 1997 |pmid= 9299399 |doi= 10.1006/bbrc.1997.7169
*cite journal | author=Nibbs RJ, Wylie SM, Yang J, "et al." |title=Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6. |journal=J. Biol. Chem. |volume=272 |issue= 51 |pages= 32078–83 |year= 1998 |pmid= 9405404 |doi=
*cite journal | author=Rubbert A, Combadiere C, Ostrowski M, "et al." |title=Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry. |journal=J. Immunol. |volume=160 |issue= 8 |pages= 3933–41 |year= 1998 |pmid= 9558100 |doi=
*cite journal | author=Noso N, Bartels J, Mallet AI, "et al." |title=Delayed production of biologically active O-glycosylated forms of human eotaxin by tumor-necrosis-factor-alpha-stimulated dermal fibroblasts. |journal=Eur. J. Biochem. |volume=253 |issue= 1 |pages= 114–22 |year= 1998 |pmid= 9578468 |doi=
*cite journal | author=Crump MP, Rajarathnam K, Kim KS, "et al." |title=Solution structure of eotaxin, a chemokine that selectively recruits eosinophils in allergic inflammation. |journal=J. Biol. Chem. |volume=273 |issue= 35 |pages= 22471–9 |year= 1998 |pmid= 9712872 |doi=
*cite journal | author=Sabroe I, Hartnell A, Jopling LA, "et al." |title=Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways. |journal=J. Immunol. |volume=162 |issue= 5 |pages= 2946–55 |year= 1999 |pmid= 10072545 |doi=
*cite journal | author=Jinquan T, Quan S, Feili G, "et al." |title=Eotaxin activates T cells to chemotaxis and adhesion only if induced to express CCR3 by IL-2 together with IL-4. |journal=J. Immunol. |volume=162 |issue= 7 |pages= 4285–92 |year= 1999 |pmid= 10201960 |doi=
*cite journal | author=Klein RS, Williams KC, Alvarez-Hernandez X, "et al." |title=Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS. |journal=J. Immunol. |volume=163 |issue= 3 |pages= 1636–46 |year= 1999 |pmid= 10415069 |doi=
*cite journal | author=Blanpain C, Migeotte I, Lee B, "et al." |title=CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist. |journal=Blood |volume=94 |issue= 6 |pages= 1899–905 |year= 1999 |pmid= 10477718 |doi=
*cite journal | author=Zhang J, Lathbury LJ, Salamonsen LA |title=Expression of the chemokine eotaxin and its receptor, CCR3, in human endometrium. |journal=Biol. Reprod. |volume=62 |issue= 2 |pages= 404–11 |year= 2000 |pmid= 10642580 |doi=
*cite journal | author=Kampen GT, Stafford S, Adachi T, "et al." |title=Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases. |journal=Blood |volume=95 |issue= 6 |pages= 1911–7 |year= 2000 |pmid= 10706854 |doi=
*cite journal | author=Huber MA, Kraut N, Addicks T, Peter RU |title=Cell-type-dependent induction of eotaxin and CCR3 by ionizing radiation. |journal=Biochem. Biophys. Res. Commun. |volume=269 |issue= 2 |pages= 546–52 |year= 2000 |pmid= 10708591 |doi= 10.1006/bbrc.2000.2287

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes