Interleukin 3

Interleukin 3 (colony-stimulating factor, multiple), also known as IL3, is a human gene.cite web | title = Entrez Gene: IL3 interleukin 3 (colony-stimulating factor, multiple)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3562| accessdate = ]

Interleukin-3 (IL-3) is an interleukin, a type of biological signal (cytokine) that can improve the body's natural response to disease as part of the immune system. It acts by binding to the Interleukin-3 receptor.

IL-3 stimulates the proliferation of hematopoietic pluripotent progenitor cells. It is secreted by activated T cells to support growth and differentiation of T cells from the bone marrow in an immune response. The human IL-3 gene encodes a protein 152 amino acids long, and the naturally occurring IL-3 is glycosylated. The human IL-3 gene is located on chromosome 5, only 9 kilobases from the GM-CSF gene, and its function is quite similar to GM-CSF.

References

Further reading

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citations =
*cite journal | author=Wagemaker G, Burger H, van Gils FC, "et al." |title=Interleukin-3. |journal=Biotherapy (Dordrecht, Netherlands) |volume=2 |issue= 4 |pages= 337–45 |year= 1991 |pmid= 2268499 |doi=
*cite journal | author=Martinez-Moczygemba M, Huston DP |title=Biology of common beta receptor-signaling cytokines: IL-3, IL-5, and GM-CSF. |journal=J. Allergy Clin. Immunol. |volume=112 |issue= 4 |pages= 653–65; quiz 666 |year= 2003 |pmid= 14564341 |doi= 10.1016/S0091 |doi_brokendate=2008-06-23
*cite journal | author=Mroczko B, Szmitkowski M |title=Hematopoietic cytokines as tumor markers. |journal=Clin. Chem. Lab. Med. |volume=42 |issue= 12 |pages= 1347–54 |year= 2005 |pmid= 15576295 |doi= 10.1515/CCLM.2004.253
*cite journal | author=Kitamura T, Sato N, Arai K, Miyajima A |title=Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors. |journal=Cell |volume=66 |issue= 6 |pages= 1165–74 |year= 1991 |pmid= 1833064 |doi=
*cite journal | author=Urdal DL, Price V, Sassenfeld HM, "et al." |title=Molecular characterization of colony-stimulating factors and their receptors: human interleukin-3. |journal=Ann. N. Y. Acad. Sci. |volume=554 |issue= |pages= 167–76 |year= 1989 |pmid= 2544122 |doi=
*cite journal | author=Otsuka T, Miyajima A, Brown N, "et al." |title=Isolation and characterization of an expressible cDNA encoding human IL-3. Induction of IL-3 mRNA in human T cell clones. |journal=J. Immunol. |volume=140 |issue= 7 |pages= 2288–95 |year= 1988 |pmid= 3127463 |doi=
*cite journal | author=Yang YC, Ciarletta AB, Temple PA, "et al." |title=Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3. |journal=Cell |volume=47 |issue= 1 |pages= 3–10 |year= 1986 |pmid= 3489530 |doi=
*cite journal | author=Le Beau MM, Epstein ND, O'Brien SJ, "et al." |title=The interleukin 3 gene is located on human chromosome 5 and is deleted in myeloid leukemias with a deletion of 5q. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 16 |pages= 5913–7 |year= 1987 |pmid= 3497400 |doi=
*cite journal | author=Dorssers L, Burger H, Bot F, "et al." |title=Characterization of a human multilineage-colony-stimulating factor cDNA clone identified by a conserved noncoding sequence in mouse interleukin-3. |journal=Gene |volume=55 |issue= 1 |pages= 115–24 |year= 1987 |pmid= 3497843 |doi=
*cite journal | author=Chirmule N, Goonewardena H, Pahwa S, "et al." |title=HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells. |journal=J. Biol. Chem. |volume=270 |issue= 33 |pages= 19364–9 |year= 1995 |pmid= 7642615 |doi=
*cite journal | author=Than S, Oyaizu N, Pahwa RN, "et al." |title=Effect of human immunodeficiency virus type-1 envelope glycoprotein gp160 on cytokine production from cord-blood T cells. |journal=Blood |volume=84 |issue= 1 |pages= 184–8 |year= 1994 |pmid= 8018916 |doi=
*cite journal | author=Le Beau MM, Espinosa R, Neuman WL, "et al." |title=Cytogenetic and molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 12 |pages= 5484–8 |year= 1993 |pmid= 8516290 |doi=
*cite journal | author=Stomski FC, Sun Q, Bagley CJ, "et al." |title=Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding. |journal=Mol. Cell. Biol. |volume=16 |issue= 6 |pages= 3035–46 |year= 1996 |pmid= 8649415 |doi=
*cite journal | author=Feng Y, Klein BK, McWherter CA |title=Three-dimensional solution structure and backbone dynamics of a variant of human interleukin-3. |journal=J. Mol. Biol. |volume=259 |issue= 3 |pages= 524–41 |year= 1996 |pmid= 8676386 |doi= 10.1006/jmbi.1996.0337
*cite journal | author=Vanhaesebroeck B, Welham MJ, Kotani K, "et al." |title=P110delta, a novel phosphoinositide 3-kinase in leukocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 9 |pages= 4330–5 |year= 1997 |pmid= 9113989 |doi=
*cite journal | author=Klein BK, Feng Y, McWherter CA, "et al." |title=The receptor binding site of human interleukin-3 defined by mutagenesis and molecular modeling. |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22630–41 |year= 1997 |pmid= 9278420 |doi=
*cite journal | author=Sanchez X, Suetomi K, Cousins-Hodges B, "et al." |title=CXC chemokines suppress proliferation of myeloid progenitor cells by activation of the CXC chemokine receptor 2. |journal=J. Immunol. |volume=160 |issue= 2 |pages= 906–10 |year= 1998 |pmid= 9551928 |doi=
*cite journal | author=Tabira T, Chui DH, Fan JP, "et al." |title=Interleukin-3 and interleukin-3 receptors in the brain. |journal=Ann. N. Y. Acad. Sci. |volume=840 |issue= |pages= 107–16 |year= 1998 |pmid= 9629242 |doi=
*cite journal | author=Nilsen EM, Johansen FE, Jahnsen FL, "et al." |title=Cytokine profiles of cultured microvascular endothelial cells from the human intestine. |journal=Gut |volume=42 |issue= 5 |pages= 635–42 |year= 1998 |pmid= 9659156 |doi=

External links

* [http://bmp.lexical.com/KS/pppo/ch17/ch17_4.html/ Structure, Function, and Clinical Applications of Interleukin-3]

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