- CXCL5
Chemokine (C-X-C motif) ligand 5, also known as CXCL5, is a human
gene .cite web | title = Entrez Gene: CXCL5 chemokine (C-X-C motif) ligand 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6374| accessdate = ]The protein encoded by this gene, CXCL5 is a small
cytokine belonging to the CXCchemokine family that is also known as epithelial-derived neutrophil-activating peptide 78 (ENA-78). It is produced following stimulation of cells with the inflammatory cytokinesinterleukin-1 ortumor necrosis factor-alpha .cite journal | author = Chang MS, McNinch J, Basu R, Simonet S | title = Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene | journal = J. Biol. Chem. | volume = 269 | issue = 41 | pages = 25277–82 | year = 1994 | pmid = 7929219 | doi = | issn = | url = http://www.jbc.org/cgi/content/abstract/269/41/25277 ] Expression of CXCL5 has also been observed ineosinophil s, and can be inhibited with the type IIinterferon IFN-γ.cite journal | author = Persson T, Monsef N, Andersson P, Bjartell A, Malm J, Calafat J, Egesten A | title = Expression of the neutrophil-activating CXC chemokine ENA-78/CXCL5 by human eosinophils | journal = Clin. Exp. Allergy | volume = 33 | issue = 4 | pages = 531–7 | year = 2003 | pmid = 12680872 | doi = 10.1046/j.1365-2222.2003.01609.x ] This chemokine stimulates the chemotaxis of neutrophils possessingangiogenic properties. It elicits these effects by interacting with the cell surfacechemokine receptor CXCR2. Thegene for CXCL5 is encoded on fourexon s and is located on humanchromosome 4 amongst several other CXC chemokine genes.cite journal | author = O'Donovan N, Galvin M, Morgan JG | title = Physical mapping of the CXC chemokine locus on human chromosome 4 | journal = Cytogenet. Cell Genet. | volume = 84 | issue = 1-2 | pages = 39–42 | year = 1999 | pmid = 10343098 | doi = 10.1159/000015209 ] CXCL5 has been implicated in connective tissue remodelling.References
Further reading
*cite journal | author=Duchene J, Lecomte F, Ahmed S, Cayla C, Pesquero J, Bader M, Perretti M, Ahluwalia A |title=A novel inflammatory pathway involved in leukocyte recruitment: role for the kinin B1 receptor and the chemokine CXCL5. |journal=J. Immunol. |volume=179 |issue= 7 |pages= 4849–56 |year= 2007 |pmid= 17878384 |doi= PBB_Further_reading
citations =
*cite journal | author=Walz A, Schmutz P, Mueller C, Schnyder-Candrian S |title=Regulation and function of the CXC chemokine ENA-78 in monocytes and its role in disease. |journal=J. Leukoc. Biol. |volume=62 |issue= 5 |pages= 604–11 |year= 1997 |pmid= 9365115 |doi=
*cite journal | author=Struyf S, Proost P, Van Damme J |title=Regulation of the immune response by the interaction of chemokines and proteases. |journal=Adv. Immunol. |volume=81 |issue= |pages= 1–44 |year= 2004 |pmid= 14711052 |doi=10.1016/S0065-2776(03)81001-5
*cite journal | author=Walz A, Burgener R, Car B, "et al." |title=Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8. |journal=J. Exp. Med. |volume=174 |issue= 6 |pages= 1355–62 |year= 1992 |pmid= 1744577 |doi=10.1084/jem.174.6.1355
*cite journal | author=Power CA, Furness RB, Brawand C, Wells TN |title=Cloning of a full-length cDNA encoding the neutrophil-activating peptide ENA-78 from human platelets. |journal=Gene |volume=151 |issue= 1-2 |pages= 333–4 |year= 1995 |pmid= 7828901 |doi=10.1016/0378-1119(94)90682-3
*cite journal | author=Chang MS, McNinch J, Basu R, Simonet S |title=Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene. |journal=J. Biol. Chem. |volume=269 |issue= 41 |pages= 25277–82 |year= 1994 |pmid= 7929219 |doi=
*cite journal | author=Corbett MS, Schmitt I, Riess O, Walz A |title=Characterization of the gene for human neutrophil-activating peptide 78 (ENA-78). |journal=Biochem. Biophys. Res. Commun. |volume=205 |issue= 1 |pages= 612–7 |year= 1995 |pmid= 7999089 |doi= 10.1006/bbrc.1994.2709
*cite journal | author=Koch AE, Kunkel SL, Harlow LA, "et al." |title=Epithelial neutrophil activating peptide-78: a novel chemotactic cytokine for neutrophils in arthritis. |journal=J. Clin. Invest. |volume=94 |issue= 3 |pages= 1012–8 |year= 1994 |pmid= 8083342 |doi=10.1172/JCI117414
*cite journal | author=Power CA, Clemetson JM, Clemetson KJ, Wells TN |title=Chemokine and chemokine receptor mRNA expression in human platelets. |journal=Cytokine |volume=7 |issue= 6 |pages= 479–82 |year= 1996 |pmid= 8580362 |doi= 10.1006/cyto.1995.0065
*cite journal | author=Ahuja SK, Murphy PM |title=The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor. |journal=J. Biol. Chem. |volume=271 |issue= 34 |pages= 20545–50 |year= 1996 |pmid= 8702798 |doi=10.1074/jbc.271.34.20545
*cite journal | author=Keates S, Keates AC, Mizoguchi E, "et al." |title=Enterocytes are the primary source of the chemokine ENA-78 in normal colon and ulcerative colitis. |journal=Am. J. Physiol. |volume=273 |issue= 1 Pt 1 |pages= G75–82 |year= 1997 |pmid= 9252512 |doi=
*cite journal | author=Wuyts A, Proost P, Lenaerts JP, "et al." |title=Differential usage of the CXC chemokine receptors 1 and 2 by interleukin-8, granulocyte chemotactic protein-2 and epithelial-cell-derived neutrophil attractant-78. |journal=Eur. J. Biochem. |volume=255 |issue= 1 |pages= 67–73 |year= 1998 |pmid= 9692902 |doi=10.1046/j.1432-1327.1998.2550067.x
*cite journal | author=Wyrick PB, Knight ST, Paul TR, "et al." |title=Persistent chlamydial envelope antigens in antibiotic-exposed infected cells trigger neutrophil chemotaxis. |journal=J. Infect. Dis. |volume=179 |issue= 4 |pages= 954–66 |year= 1999 |pmid= 10068592 |doi=10.1086/314676
*cite journal | author=Wuyts A, Govaerts C, Struyf S, "et al." |title=Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms. |journal=Eur. J. Biochem. |volume=260 |issue= 2 |pages= 421–9 |year= 1999 |pmid= 10095777 |doi=10.1046/j.1432-1327.1999.00166.x
*cite journal | author=Hogaboam CM, Bone-Larson CL, Steinhauser ML, "et al." |title=Novel CXCR2-dependent liver regenerative qualities of ELR-containing CXC chemokines. |journal=Faseb J. |volume=13 |issue= 12 |pages= 1565–74 |year= 1999 |pmid= 10463948 |doi=
*cite journal | author=Luu NT, Rainger GE, Nash GB |title=Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils. |journal=J. Immunol. |volume=164 |issue= 11 |pages= 5961–9 |year= 2000 |pmid= 10820279 |doi=
*cite journal | author=Crane IJ, Wallace CA, McKillop-Smith S, Forrester JV |title=Control of chemokine production at the blood-retina barrier. |journal=Immunology |volume=101 |issue= 3 |pages= 426–33 |year= 2000 |pmid= 11106948 |doi=10.1046/j.0019-2805.2000.01105.x
*cite journal | author=Zhang C, Thornton MA, Kowalska MA, "et al." |title=Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus. |journal=Blood |volume=98 |issue= 3 |pages= 610–7 |year= 2001 |pmid= 11468158 |doi=10.1182/blood.V98.3.610
*cite journal | author=Chandrasekar B, Melby PC, Sarau HM, "et al." |title=Chemokine-cytokine cross-talk. The ELR+ CXC chemokine LIX (CXCL5) amplifies a proinflammatory cytokine response via a phosphatidylinositol 3-kinase-NF-kappa B pathway. |journal=J. Biol. Chem. |volume=278 |issue= 7 |pages= 4675–86 |year= 2003 |pmid= 12468547 |doi= 10.1074/jbc.M207006200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899PBB_Controls
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