Interleukin 29

Interleukin 29

protein
Name = Interleukin 29
caption =


width =
HGNCid = 18363
Symbol = IL29
AltSymbols = , IFNL1
EntrezGene = 282618
OMIM = 607403
RefSeq = NM_172140
UniProt = Q8IU54
PDB =
ECnumber =
Chromosome = 19
Arm = q
Band = 13.13
LocusSupplementaryData =

Interleukin-29 (IL-29) is a protein of the helical cytokine family and is a type III interferon. [Vilcek, Novel interferons. Nature Immunology, 2003, Volume 4, pages 8-9 ] It is also known as IFNλ1 and is highly similar in amino acid sequence to the IL-28, the other type III interferon.

IL-29 plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses.

The IL-29 gene is found on chromosome 19 in humans. [P. Sheppard, et al., IL-28, IL-29 and their class II cytokine receptor IL-28R. Nature Immunology, 2003, Volume 4, pages 63-68.]

References


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