CCL14

protein
Name = chemokine (C-C motif) ligand 14
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HGNCid = 10612
Symbol = CCL14
AltSymbols = SCYA14, HCC-1, HCC-3, NCC-2, SCYL2, CKb1, MCIF
EntrezGene = 6358
OMIM = 601392
RefSeq = NM_032962
UniProt = Q16627
PDB =
ECnumber =
Chromosome = 17
Arm = q
Band = 11.2
LocusSupplementaryData =

Chemokine (C-C motif) ligand 14 (CCL14) is a small cytokine belonging to the CC chemokine family. It is also commonly known as HCC-1. It is produced as a protein precursor that is procesed to generate a mature active protein containing 74 amino acids that and is 46% identical in amino acid composition to CCL3 and CCL4. This chemokine is expressed in various tissues including spleen, bone marrow, liver, muscle, and gut. [Schulz-Knappe et al., HCC-1, a novel chemokine from human plasma. J. Exp. Med., 1996, 183: 295-299.] CCL13 activates monocytes, but does not induce their chemotaxis. Human CCL13 is located on chromosome 17 within a cluster of other chemokines belonging to the CC family. [Naruseet al., A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics, 1996, 34: 236-240. ]

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