- IL1F7
Interleukin 1 family, member 7 (zeta), also known as IL1F7, is a human
gene .cite web | title = Entrez Gene: IL1F7 interleukin 1 family, member 7 (zeta)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27178| accessdate = ]PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported.cite web | title = Entrez Gene: IL1F7 interleukin 1 family, member 7 (zeta)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27178| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Nicklin MJ, Weith A, Duff GW |title=A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes. |journal=Genomics |volume=19 |issue= 2 |pages= 382–4 |year= 1994 |pmid= 8188271 |doi= 10.1006/geno.1994.1076
*cite journal | author=Nothwang HG, Strahm B, Denich D, "et al." |title=Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13. |journal=Genomics |volume=41 |issue= 3 |pages= 370–8 |year= 1997 |pmid= 9169134 |doi= 10.1006/geno.1997.4654
*cite journal | author=Mulero JJ, Pace AM, Nelken ST, "et al." |title=IL1HY1: A novel interleukin-1 receptor antagonist gene. |journal=Biochem. Biophys. Res. Commun. |volume=263 |issue= 3 |pages= 702–6 |year= 1999 |pmid= 10512743 |doi= 10.1006/bbrc.1999.1440
*cite journal | author=Smith DE, Renshaw BR, Ketchem RR, "et al." |title=Four new members expand the interleukin-1 superfamily. |journal=J. Biol. Chem. |volume=275 |issue= 2 |pages= 1169–75 |year= 2000 |pmid= 10625660 |doi=
*cite journal | author=Kumar S, McDonnell PC, Lehr R, "et al." |title=Identification and initial characterization of four novel members of the interleukin-1 family. |journal=J. Biol. Chem. |volume=275 |issue= 14 |pages= 10308–14 |year= 2000 |pmid= 10744718 |doi=
*cite journal | author=Busfield SJ, Comrack CA, Yu G, "et al." |title=Identification and gene organization of three novel members of the IL-1 family on human chromosome 2. |journal=Genomics |volume=66 |issue= 2 |pages= 213–6 |year= 2000 |pmid= 10860666 |doi= 10.1006/geno.2000.6184
*cite journal | author=Barton JL, Herbst R, Bosisio D, "et al." |title=A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities. |journal=Eur. J. Immunol. |volume=30 |issue= 11 |pages= 3299–308 |year= 2001 |pmid= 11093146 |doi=
*cite journal | author=Pan G, Risser P, Mao W, "et al." |title=IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp. |journal=Cytokine |volume=13 |issue= 1 |pages= 1–7 |year= 2001 |pmid= 11145836 |doi= 10.1006/cyto.2000.0799
*cite journal | author=Lin H, Ho AS, Haley-Vicente D, "et al." |title=Cloning and characterization of IL-1HY2, a novel interleukin-1 family member. |journal=J. Biol. Chem. |volume=276 |issue= 23 |pages= 20597–602 |year= 2001 |pmid= 11278614 |doi= 10.1074/jbc.M010095200
*cite journal | author=Debets R, Timans JC, Homey B, "et al." |title=Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. |journal=J. Immunol. |volume=167 |issue= 3 |pages= 1440–6 |year= 2001 |pmid= 11466363 |doi=
*cite journal | author=Sims JE, Nicklin MJ, Bazan JF, "et al." |title=A new nomenclature for IL-1-family genes. |journal=Trends Immunol. |volume=22 |issue= 10 |pages= 536–7 |year= 2001 |pmid= 11574262 |doi=
*cite journal | author=Nicklin MJ, Barton JL, Nguyen M, "et al." |title=A sequence-based map of the nine genes of the human interleukin-1 cluster. |journal=Genomics |volume=79 |issue= 5 |pages= 718–25 |year= 2002 |pmid= 11991722 |doi= 10.1006/geno.2002.6751
*cite journal | author=Taylor SL, Renshaw BR, Garka KE, "et al." |title=Genomic organization of the interleukin-1 locus. |journal=Genomics |volume=79 |issue= 5 |pages= 726–33 |year= 2002 |pmid= 11991723 |doi= 10.1006/geno.2002.6752
*cite journal | author=Kumar S, Hanning CR, Brigham-Burke MR, "et al." |title=Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production. |journal=Cytokine |volume=18 |issue= 2 |pages= 61–71 |year= 2003 |pmid= 12096920 |doi=
*cite journal | author=Bufler P, Azam T, Gamboni-Robertson F, "et al." |title=A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 21 |pages= 13723–8 |year= 2002 |pmid= 12381835 |doi= 10.1073/pnas.212519099
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gao W, Kumar S, Lotze MT, "et al." |title=Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor immunity. |journal=J. Immunol. |volume=170 |issue= 1 |pages= 107–13 |year= 2003 |pmid= 12496389 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Grimsby S, Jaensson H, Dubrovska A, "et al." |title=Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity. |journal=FEBS Lett. |volume=577 |issue= 1-2 |pages= 93–100 |year= 2005 |pmid= 15527767 |doi= 10.1016/j.febslet.2004.09.069
*cite journal | author=Hillier LW, Graves TA, Fulton RS, "et al." |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466PBB_Controls
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