IL17A

Interleukin 17A, also known as IL17A, is a human gene.cite web | title = Entrez Gene: IL17A interleukin 17A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3605| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.cite web | title = Entrez Gene: IL17A interleukin 17A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3605| accessdate = ]

ee also

* Interleukin 17

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gaffen SL |title=Biology of recently discovered cytokines: interleukin-17--a unique inflammatory cytokine with roles in bone biology and arthritis. |journal=Arthritis Res. Ther. |volume=6 |issue= 6 |pages= 240–7 |year= 2005 |pmid= 15535837 |doi= 10.1186/ar1444
*cite journal | author=Lubberts E, Koenders MI, van den Berg WB |title=The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models. |journal=Arthritis Res. Ther. |volume=7 |issue= 1 |pages= 29–37 |year= 2006 |pmid= 15642151 |doi= 10.1186/ar1478
*cite journal | author=Yao Z, Painter SL, Fanslow WC, "et al." |title=Human IL-17: a novel cytokine derived from T cells. |journal=J. Immunol. |volume=155 |issue= 12 |pages= 5483–6 |year= 1996 |pmid= 7499828 |doi=
*cite journal | author=Rouvier E, Luciani MF, Mattéi MG, "et al." |title=CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. |journal=J. Immunol. |volume=150 |issue= 12 |pages= 5445–56 |year= 1993 |pmid= 8390535 |doi=
*cite journal | author=Fossiez F, Djossou O, Chomarat P, "et al." |title=T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. |journal=J. Exp. Med. |volume=183 |issue= 6 |pages= 2593–603 |year= 1996 |pmid= 8676080 |doi=
*cite journal | author=Yao Z, Spriggs MK, Derry JM, "et al." |title=Molecular characterization of the human interleukin (IL)-17 receptor. |journal=Cytokine |volume=9 |issue= 11 |pages= 794–800 |year= 1998 |pmid= 9367539 |doi=
*cite journal | author=Murphy KP, Gagne P, Pazmany C, Moody MD |title=Expression of human interleukin-17 in Pichia pastoris: purification and characterization. |journal=Protein Expr. Purif. |volume=12 |issue= 2 |pages= 208–14 |year= 1998 |pmid= 9518462 |doi= 10.1006/prep.1997.0832
*cite journal | author=Teunissen MB, Koomen CW, de Waal Malefyt R, "et al." |title=Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes. |journal=J. Invest. Dermatol. |volume=111 |issue= 4 |pages= 645–9 |year= 1998 |pmid= 9764847 |doi= 10.1046/j.1523-1747.1998.00347.x
*cite journal | author=Shalom-Barak T, Quach J, Lotz M |title=Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappaB. |journal=J. Biol. Chem. |volume=273 |issue= 42 |pages= 27467–73 |year= 1998 |pmid= 9765276 |doi=
*cite journal | author=Shin HC, Benbernou N, Fekkar H, "et al." |title=Regulation of IL-17, IFN-gamma and IL-10 in human CD8(+) T cells by cyclic AMP-dependent signal transduction pathway. |journal=Cytokine |volume=10 |issue= 11 |pages= 841–50 |year= 1999 |pmid= 9878122 |doi= 10.1006/cyto.1998.0375
*cite journal | author=Laan M, Cui ZH, Hoshino H, "et al." |title=Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. |journal=J. Immunol. |volume=162 |issue= 4 |pages= 2347–52 |year= 1999 |pmid= 9973514 |doi=
*cite journal | author=Kotake S, Udagawa N, Takahashi N, "et al." |title=IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. |journal=J. Clin. Invest. |volume=103 |issue= 9 |pages= 1345–52 |year= 1999 |pmid= 10225978 |doi=
*cite journal | author=Shin HC, Benbernou N, Esnault S, Guenounou M |title=Expression of IL-17 in human memory CD45RO+ T lymphocytes and its regulation by protein kinase A pathway. |journal=Cytokine |volume=11 |issue= 4 |pages= 257–66 |year= 1999 |pmid= 10328864 |doi= 10.1006/cyto.1998.0433
*cite journal | author=Andoh A, Takaya H, Makino J, "et al." |title=Cooperation of interleukin-17 and interferon-gamma on chemokine secretion in human fetal intestinal epithelial cells. |journal=Clin. Exp. Immunol. |volume=125 |issue= 1 |pages= 56–63 |year= 2001 |pmid= 11472426 |doi=
*cite journal | author=Laan M, Palmberg L, Larsson K, Lindén A |title=Free, soluble interleukin-17 protein during severe inflammation in human airways. |journal=Eur. Respir. J. |volume=19 |issue= 3 |pages= 534–7 |year= 2002 |pmid= 11936535 |doi=
*cite journal | author=Andoh A, Fujino S, Bamba S, "et al." |title=IL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts. |journal=J. Immunol. |volume=169 |issue= 4 |pages= 1683–7 |year= 2002 |pmid= 12165487 |doi=
*cite journal | author=Andoh A, Shimada M, Bamba S, "et al." |title=Extracellular signal-regulated kinases 1 and 2 participate in interleukin-17 plus tumor necrosis factor-alpha-induced stabilization of interleukin-6 mRNA in human pancreatic myofibroblasts. |journal=Biochim. Biophys. Acta |volume=1591 |issue= 1-3 |pages= 69–74 |year= 2002 |pmid= 12183057 |doi=
*cite journal | author=Hsieh HG, Loong CC, Lin CY |title=Interleukin-17 induces src/MAPK cascades activation in human renal epithelial cells. |journal=Cytokine |volume=19 |issue= 4 |pages= 159–74 |year= 2003 |pmid= 12297109 |doi=
*cite journal | author=Aggarwal S, Ghilardi N, Xie MH, "et al." |title=Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. |journal=J. Biol. Chem. |volume=278 |issue= 3 |pages= 1910–4 |year= 2003 |pmid= 12417590 |doi= 10.1074/jbc.M207577200
*cite journal | author=Maertzdorf J, Osterhaus AD, Verjans GM |title=IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts. |journal=J. Immunol. |volume=169 |issue= 10 |pages= 5897–903 |year= 2003 |pmid= 12421973 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes