CXCL6

protein
Name = chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)
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HGNCid = 10643
Symbol = CXCL6
AltSymbols = SCYB6, GCP-2, CKA-3
EntrezGene = 6372
OMIM = 138965
RefSeq = NM_002993
UniProt = P80162
PDB =
ECnumber =
Chromosome = 4
Arm = q
Band = 21
LocusSupplementaryData =

Chemokine (C-X-C motif) ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family that is also known as granulocyte chemotactic protein 2 (GCP-2). As its former name suggests, CXCL6 is a chemoattractant for neutrophilic granulocytes. [cite journal |author=Proost P, Wuyts A, Conings R, Lenaerts J, Billiau A, Opdenakker G, Van Damme J |title=Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines |journal=Biochemistry |volume=32 |issue=38 |pages=10170–7 |year=1993 |pmid=8399143 |doi=10.1021/bi00089a037] cite journal |author=Wuyts A, Van Osselaer N, Haelens A, Samson I, Herdewijn P, Ben-Baruch A, Oppenheim J, Proost P, Van Damme J |title=Characterization of synthetic human granulocyte chemotactic protein 2: usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties |journal=Biochemistry |volume=36 |issue=9 |pages=2716–23 |year=1997 |pmid=9054580 |doi=10.1021/bi961999z] It elicits its chemotactic effects by interacting with the chemokine receptors CXCR1 and CXCR2. The gene for CXCL6 is located on human chromosome 4 in a cluster with other CXC chemokine genes. [cite journal |author=Modi W, Chen Z |title=Localization of the human CXC chemokine subfamily on the long arm of chromosome 4 using radiation hybrids |journal=Genomics |volume=47 |issue=1 |pages=136–9 |year=1998 |pmid=9465307 |doi=10.1006/geno.1997.5100] [cite journal |author=O'Donovan N, Galvin M, Morgan J |title=Physical mapping of the CXC chemokine locus on human chromosome 4 |journal=Cytogenet Cell Genet |volume=84 |issue=1-2 |pages=39–42 |year=1999 |pmid=10343098 |doi=10.1159/000015209]

References