CXCR7

Chemokine (C-X-C motif) receptor 7, also known as CXCR7, is a human gene.cite web | title = Entrez Gene: CXCR7 chemokine (C-X-C motif) receptor 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57007| accessdate = ]

This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP) and was considered to be an orphan receptor, it has been later been shown to bind the chemokines CXCL12/SDF-1 and CXCL11. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. Whereas some reports claim that the receptor induces signaling following ligand binding, recent findings in zebrafish suggest that CXCR7 functions primarily by sequestering the chemokine CXCL12. cite web | title = Entrez Gene: CXCR7 chemokine (C-X-C motif) receptor 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57007| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nagata S, Ishihara T, Robberecht P, "et al." |title=RDC1 may not be VIP receptor. |journal=Trends Pharmacol. Sci. |volume=13 |issue= 3 |pages= 102–3 |year= 1992 |pmid= 1315461 |doi=
*cite journal | author=Libert F, Passage E, Parmentier M, "et al." |title=Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor. |journal=Genomics |volume=11 |issue= 1 |pages= 225–7 |year= 1992 |pmid= 1662665 |doi=
*cite journal | author=Sreedharan SP, Robichon A, Peterson KE, Goetzl EJ |title=Cloning and expression of the human vasoactive intestinal peptide receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 11 |pages= 4986–90 |year= 1991 |pmid= 1675791 |doi=
*cite journal | author=Law NM, Rosenzweig SA |title=Characterization of the G-protein linked orphan receptor GPRN1/RDC1. |journal=Biochem. Biophys. Res. Commun. |volume=201 |issue= 1 |pages= 458–65 |year= 1994 |pmid= 8198609 |doi= 10.1006/bbrc.1994.1723
*cite journal | author=Shimizu N, Soda Y, Kanbe K, "et al." |title=A putative G protein-coupled receptor, RDC1, is a novel coreceptor for human and simian immunodeficiency viruses. |journal=J. Virol. |volume=74 |issue= 2 |pages= 619–26 |year= 2000 |pmid= 10623723 |doi=
*cite journal | author=Broberg K, Zhang M, Strömbeck B, "et al." |title=Fusion of RDC1 with HMGA2 in lipomas as the result of chromosome aberrations involving 2q35-37 and 12q13-15. |journal=Int. J. Oncol. |volume=21 |issue= 2 |pages= 321–6 |year= 2003 |pmid= 12118328 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Hillier LW, Graves TA, Fulton RS, "et al." |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466
*cite journal | author=Balabanian K, Lagane B, Infantino S, "et al." |title=The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes. |journal=J. Biol. Chem. |volume=280 |issue= 42 |pages= 35760–6 |year= 2005 |pmid= 16107333 |doi= 10.1074/jbc.M508234200
*cite journal | author=Infantino S, Moepps B, Thelen M |title=Expression and regulation of the orphan receptor RDC1 and its putative ligand in human dendritic and B cells. |journal=J. Immunol. |volume=176 |issue= 4 |pages= 2197–207 |year= 2006 |pmid= 16455976 |doi=
*cite journal | author=Burns JM, Summers BC, Wang Y, "et al." |title=A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. |journal=J. Exp. Med. |volume=203 |issue= 9 |pages= 2201–13 |year= 2006 |pmid= 16940167 |doi= 10.1084/jem.20052144
*cite journal | author=Proost P, Mortier A, Loos T, "et al." |title=Proteolytic processing of CXCL11 by CD13/aminopeptidase N impairs CXCR3 and CXCR7 binding and signaling and reduces lymphocyte and endothelial cell migration. |journal=Blood |volume=110 |issue= 1 |pages= 37–44 |year= 2007 |pmid= 17363734 |doi= 10.1182/blood-2006-10-049072
*cite journal | author=Miao Z, Luker KE, "et al." |title=CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature. |journal=PNAS | volume=104 |pages= 15735–15740 |year=2007 |doi=10.1073/pnas.0610444104
*cite journal|author=Wang J, Shiozawa Y, Wang J "et al." |title=The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer. |journal=J Biol Chem |volume=283 |year= 2008 |pages=number=4283–4294 |doi=10.1074/jbc.M707465200
*cite journal|author=Boldajipour B, Mahabaleshwar H, Kardash E "et al" |title=Control of Chemokine-Guided Cell Migration by Ligand Sequestration. |journal=Cell |volume=132 |year= 2008 |pages=463-473 | pmid=18267076 |doi=10.1016/j.cell.2007.12.034

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