IL2RB

Interleukin 2 receptor, beta, also known as IL2RB, is a human gene.cite web | title = Entrez Gene: IL2RB interleukin 2 receptor, beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3560| accessdate = ]

PBB_Summary
section_title =
summary_text = The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein.cite web | title = Entrez Gene: IL2RB interleukin 2 receptor, beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3560| accessdate = ]

ee also

* IL-2 receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ellery JM, Nicholls PJ |title=Alternate signalling pathways from the interleukin-2 receptor. |journal=Cytokine Growth Factor Rev. |volume=13 |issue= 1 |pages= 27–40 |year= 2002 |pmid= 11750878 |doi=
*cite journal | author=Purvis SF, Georges DL, Williams TM, Lederman MM |title=Suppression of interleukin-2 and interleukin-2 receptor expression in Jurkat cells stably expressing the human immunodeficiency virus Tat protein. |journal=Cell. Immunol. |volume=144 |issue= 1 |pages= 32–42 |year= 1992 |pmid= 1394441 |doi=
*cite journal | author=Torigoe T, Saragovi HU, Reed JC |title=Interleukin 2 regulates the activity of the lyn protein-tyrosine kinase in a B-cell line. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 7 |pages= 2674–8 |year= 1992 |pmid= 1557373 |doi=
*cite journal | author=Maslinski W, Remillard B, Tsudo M, Strom TB |title=Interleukin-2 (IL-2) induces tyrosine kinase-dependent translocation of active raf-1 from the IL-2 receptor into the cytosol. |journal=J. Biol. Chem. |volume=267 |issue= 22 |pages= 15281–4 |year= 1992 |pmid= 1639773 |doi=
*cite journal | author=Miyazaki T, Maruyama M, Yamada G, "et al." |title=The integrity of the conserved 'WS motif' common to IL-2 and other cytokine receptors is essential for ligand binding and signal transduction. |journal=EMBO J. |volume=10 |issue= 11 |pages= 3191–7 |year= 1991 |pmid= 1915291 |doi=
*cite journal | author=Shibuya H, Yoneyama M, Nakamura Y, "et al." |title=The human interleukin-2 receptor beta-chain gene: genomic organization, promoter analysis and chromosomal assignment. |journal=Nucleic Acids Res. |volume=18 |issue= 13 |pages= 3697–703 |year= 1990 |pmid= 1973832 |doi=
*cite journal | author=Hatakeyama M, Kono T, Kobayashi N, "et al." |title=Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular association. |journal=Science |volume=252 |issue= 5012 |pages= 1523–8 |year= 1991 |pmid= 2047859 |doi=
*cite journal | author=Mills GB, May C, McGill M, "et al." |title=Interleukin 2-induced tyrosine phosphorylation. Interleukin 2 receptor beta is tyrosine phosphorylated. |journal=J. Biol. Chem. |volume=265 |issue= 6 |pages= 3561–7 |year= 1990 |pmid= 2303462 |doi=
*cite journal | author=Oyaizu N, Chirmule N, Kalyanaraman VS, "et al." |title=Human immunodeficiency virus type 1 envelope glycoprotein gp120 produces immune defects in CD4+ T lymphocytes by inhibiting interleukin 2 mRNA. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 6 |pages= 2379–83 |year= 1990 |pmid= 2315327 |doi=
*cite journal | author=Gnarra JR, Otani H, Wang MG, "et al." |title=Human interleukin 2 receptor beta-chain gene: chromosomal localization and identification of 5' regulatory sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 9 |pages= 3440–4 |year= 1990 |pmid= 2333293 |doi=
*cite journal | author=Tsudo M, Kitamura F, Miyasaka M |title=Characterization of the interleukin 2 receptor beta chain using three distinct monoclonal antibodies. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 6 |pages= 1982–6 |year= 1989 |pmid= 2467293 |doi=
*cite journal | author=Hatakeyama M, Tsudo M, Minamoto S, "et al." |title=Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's. |journal=Science |volume=244 |issue= 4904 |pages= 551–6 |year= 1989 |pmid= 2785715 |doi=
*cite journal | author=Kornfeld H, Cruikshank WW, Pyle SW, "et al." |title=Lymphocyte activation by HIV-1 envelope glycoprotein. |journal=Nature |volume=335 |issue= 6189 |pages= 445–8 |year= 1988 |pmid= 2843775 |doi= 10.1038/335445a0
*cite journal | author=Leonard WJ, Donlon TA, Lebo RV, Greene WC |title=Localization of the gene encoding the human interleukin-2 receptor on chromosome 10. |journal=Science |volume=228 |issue= 4707 |pages= 1547–9 |year= 1985 |pmid= 3925551 |doi=
*cite journal | author=Bamborough P, Hedgecock CJ, Richards WG |title=The interleukin-2 and interleukin-4 receptors studied by molecular modelling. |journal=Structure |volume=2 |issue= 9 |pages= 839–51 |year= 1995 |pmid= 7529123 |doi=
*cite journal | author=Minami Y, Nakagawa Y, Kawahara A, "et al." |title=Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathway. |journal=Immunity |volume=2 |issue= 1 |pages= 89–100 |year= 1995 |pmid= 7600304 |doi=
*cite journal | author=Giri JG, Kumaki S, Ahdieh M, "et al." |title=Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. |journal=EMBO J. |volume=14 |issue= 15 |pages= 3654–63 |year= 1995 |pmid= 7641685 |doi=
*cite journal | author=Kirken RA, Rui H, Evans GA, Farrar WL |title=Characterization of an interleukin-2 (IL-2)-induced tyrosine phosphorylated 116-kDa protein associated with the IL-2 receptor beta-subunit. |journal=J. Biol. Chem. |volume=268 |issue= 30 |pages= 22765–70 |year= 1993 |pmid= 7693677 |doi=
*cite journal | author=Puri RK, Leland P, Aggarwal BB |title=Constitutive expression of human immunodeficiency virus type 1 tat gene inhibits interleukin 2 and interleukin 2 receptor expression in a human CD4+ T lymphoid (H9) cell line. |journal=AIDS Res. Hum. Retroviruses |volume=11 |issue= 1 |pages= 31–40 |year= 1995 |pmid= 7734194 |doi=
*cite journal | author=Miyazaki T, Liu ZJ, Kawahara A, "et al." |title=Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. |journal=Cell |volume=81 |issue= 2 |pages= 223–31 |year= 1995 |pmid= 7736574 |doi=

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