CD43

Sialophorin (leukosialin, CD43), also known as SPN, is a human gene.cite web | title = Entrez Gene: SPN sialophorin (leukosialin, CD43)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6693| accessdate = ]

PBB_Summary
section_title =
summary_text = Sialophorin (leukosialin) is a major sialoglycoprotein on the surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes, which appears to be important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation. [supplied by OMIM] cite web | title = Entrez Gene: SPN sialophorin (leukosialin, CD43)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6693| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Fukuda M, Carlsson SR |title=Leukosialin, a major sialoglycoprotein on human leukocytes as differentiation antigens. |journal=Med. Biol. |volume=64 |issue= 6 |pages= 335–43 |year= 1987 |pmid= 2950285 |doi=
*cite journal | author=Rogaev EI, Keryanov SA |title=Unusual variability of the complex dinucleotide repeat block at the SPN locus. |journal=Hum. Mol. Genet. |volume=1 |issue= 8 |pages= 657 |year= 1993 |pmid= 1301183 |doi=
*cite journal | author=Rosenstein Y, Park JK, Hahn WC, "et al." |title=CD43, a molecule defective in Wiskott-Aldrich syndrome, binds ICAM-1. |journal=Nature |volume=354 |issue= 6350 |pages= 233–5 |year= 1992 |pmid= 1683685 |doi= 10.1038/354233a0
*cite journal | author=Schmid K, Hediger MA, Brossmer R, "et al." |title=Amino acid sequence of human plasma galactoglycoprotein: identity with the extracellular region of CD43 (sialophorin). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 2 |pages= 663–7 |year= 1992 |pmid= 1731338 |doi=
*cite journal | author=Kudo S, Fukuda M |title=A short, novel promoter sequence confers the expression of human leukosialin, a major sialoglycoprotein on leukocytes. |journal=J. Biol. Chem. |volume=266 |issue= 13 |pages= 8483–9 |year= 1991 |pmid= 1827122 |doi=
*cite journal | author=Park JK, Rosenstein YJ, Remold-O'Donnell E, "et al." |title=Enhancement of T-cell activation by the CD43 molecule whose expression is defective in Wiskott-Aldrich syndrome. |journal=Nature |volume=350 |issue= 6320 |pages= 706–9 |year= 1991 |pmid= 2023632 |doi= 10.1038/350706a0
*cite journal | author=Shelley CS, Remold-O'Donnell E, Rosen FS, Whitehead AS |title=Structure of the human sialophorin (CD43) gene. Identification of features atypical of genes encoding integral membrane proteins. |journal=Biochem. J. |volume=270 |issue= 3 |pages= 569–76 |year= 1990 |pmid= 2241892 |doi=
*cite journal | author=Pallant A, Eskenazi A, Mattei MG, "et al." |title=Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 4 |pages= 1328–32 |year= 1989 |pmid= 2521952 |doi=
*cite journal | author=Shelley CS, Remold-O'Donnell E, Davis AE, "et al." |title=Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 8 |pages= 2819–23 |year= 1989 |pmid= 2784859 |doi=
*cite journal | author=Srinivas RV, Su T, Trimble LA, "et al." |title=Enhanced susceptibility to human immunodeficiency virus infection in CD4+ T lymphocytes genetically deficient in CD43. |journal=AIDS Res. Hum. Retroviruses |volume=11 |issue= 9 |pages= 1015–21 |year= 1996 |pmid= 8554898 |doi=
*cite journal | author=Hirao M, Sato N, Kondo T, "et al." |title=Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway. |journal=J. Cell Biol. |volume=135 |issue= 1 |pages= 37–51 |year= 1996 |pmid= 8858161 |doi=
*cite journal | author=Yonemura S, Hirao M, Doi Y, "et al." |title=Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2. |journal=J. Cell Biol. |volume=140 |issue= 4 |pages= 885–95 |year= 1998 |pmid= 9472040 |doi=
*cite journal | author=Pedraza-Alva G, Mérida LB, Burakoff SJ, Rosenstein Y |title=T cell activation through the CD43 molecule leads to Vav tyrosine phosphorylation and mitogen-activated protein kinase pathway activation. |journal=J. Biol. Chem. |volume=273 |issue= 23 |pages= 14218–24 |year= 1998 |pmid= 9603925 |doi=
*cite journal | author=Serrador JM, Nieto M, Alonso-Lebrero JL, "et al." |title=CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contacts. |journal=Blood |volume=91 |issue= 12 |pages= 4632–44 |year= 1998 |pmid= 9616160 |doi=
*cite journal | author=Pace KE, Lee C, Stewart PL, Baum LG |title=Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1. |journal=J. Immunol. |volume=163 |issue= 7 |pages= 3801–11 |year= 1999 |pmid= 10490978 |doi=
*cite journal | author=Seveau S, Keller H, Maxfield FR, "et al." |title=Neutrophil polarity and locomotion are associated with surface redistribution of leukosialin (CD43), an antiadhesive membrane molecule. |journal=Blood |volume=95 |issue= 8 |pages= 2462–70 |year= 2000 |pmid= 10753822 |doi=
*cite journal | author=Fratazzi C, Manjunath N, Arbeit RD, "et al." |title=A macrophage invasion mechanism for mycobacteria implicating the extracellular domain of CD43. |journal=J. Exp. Med. |volume=192 |issue= 2 |pages= 183–92 |year= 2000 |pmid= 10899905 |doi=
*cite journal | author=Santana MA, Pedraza-Alva G, Olivares-Zavaleta N, "et al." |title=CD43-mediated signals induce DNA binding activity of AP-1, NF-AT, and NFkappa B transcription factors in human T lymphocytes. |journal=J. Biol. Chem. |volume=275 |issue= 40 |pages= 31460–8 |year= 2000 |pmid= 10908570 |doi= 10.1074/jbc.M005231200
*cite journal | author=van den Berg TK, Nath D, Ziltener HJ, "et al." |title=Cutting edge: CD43 functions as a T cell counterreceptor for the macrophage adhesion receptor sialoadhesin (Siglec-1). |journal=J. Immunol. |volume=166 |issue= 6 |pages= 3637–40 |year= 2001 |pmid= 11238599 |doi=

External links

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