CD1E

CD1e molecule, also known as CD1E, is a human gene.cite web | title = Entrez Gene: CD1E CD1e molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=913| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Several alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found; however, their biological validity has not been determined.cite web | title = Entrez Gene: CD1E CD1e molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=913| accessdate = ]

ee also

* Cluster of differentiation

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Brigl M, Brenner MB |title=CD1: antigen presentation and T cell function. |journal=Annu. Rev. Immunol. |volume=22 |issue= |pages= 817–90 |year= 2004 |pmid= 15032598 |doi= 10.1146/annurev.immunol.22.012703.104608
*cite journal | author=Calabi F, Jarvis JM, Martin L, Milstein C |title=Two classes of CD1 genes. |journal=Eur. J. Immunol. |volume=19 |issue= 2 |pages= 285–92 |year= 1989 |pmid= 2467814 |doi=
*cite journal | author=Yu CY, Milstein C |title=A physical map linking the five CD1 human thymocyte differentiation antigen genes. |journal=EMBO J. |volume=8 |issue= 12 |pages= 3727–32 |year= 1990 |pmid= 2583117 |doi=
*cite journal | author=Albertson DG, Fishpool R, Sherrington P, "et al." |title=Sensitive and high resolution in situ hybridization to human chromosomes using biotin labelled probes: assignment of the human thymocyte CD1 antigen genes to chromosome 1. |journal=EMBO J. |volume=7 |issue= 9 |pages= 2801–5 |year= 1988 |pmid= 3053166 |doi=
*cite journal | author=Martin LH, Calabi F, Milstein C |title=Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 23 |pages= 9154–8 |year= 1987 |pmid= 3097645 |doi=
*cite journal | author=Adams MD, Kerlavage AR, Fleischmann RD, "et al." |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3–174 |year= 1995 |pmid= 7566098 |doi=
*cite journal | author=Han M, Hannick LI, DiBrino M, Robinson MA |title=Polymorphism of human CD1 genes. |journal=Tissue Antigens |volume=54 |issue= 2 |pages= 122–7 |year= 2000 |pmid= 10488738 |doi=
*cite journal | author=Angenieux C, Salamero J, Fricker D, "et al." |title=Characterization of CD1e, a third type of CD1 molecule expressed in dendritic cells. |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37757–64 |year= 2001 |pmid= 10948205 |doi= 10.1074/jbc.M007082200
*cite journal | author=Mirones I, Oteo M, Parra-Cuadrado JF, Martínez-Naves E |title=Identification of two novel human CD1E alleles. |journal=Tissue Antigens |volume=56 |issue= 2 |pages= 159–61 |year= 2001 |pmid= 11019917 |doi=
*cite journal | author=Tamouza R, Sghiri R, Ramasawmy R, "et al." |title=Two novel CD1 E alleles identified in black African individuals. |journal=Tissue Antigens |volume=59 |issue= 5 |pages= 417–20 |year= 2003 |pmid= 12144626 |doi=
*cite journal | author=Angénieux C, Salamero J, Fricker D, "et al." |title=Common characteristics of the human and rhesus macaque CD1e molecules: conservation of biochemical and biological properties during primate evolution. |journal=Immunogenetics |volume=54 |issue= 12 |pages= 842–9 |year= 2003 |pmid= 12671734 |doi= 10.1007/s00251-003-0538-0
*cite journal | author=Angénieux C, Fraisier V, Maître B, "et al." |title=The cellular pathway of CD1e in immature and maturing dendritic cells. |journal=Traffic |volume=6 |issue= 4 |pages= 286–302 |year= 2005 |pmid= 15752135 |doi= 10.1111/j.1600-0854.2005.00272.x
*cite journal | author=de la Salle H, Mariotti S, Angenieux C, "et al." |title=Assistance of microbial glycolipid antigen processing by CD1e. |journal=Science |volume=310 |issue= 5752 |pages= 1321–4 |year= 2005 |pmid= 16311334 |doi= 10.1126/science.1115301
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Caporale CM, Papola F, Fioroni MA, "et al." |title=Susceptibility to Guillain-Barré syndrome is associated to polymorphisms of CD1 genes. |journal=J. Neuroimmunol. |volume=177 |issue= 1-2 |pages= 112–8 |year= 2006 |pmid= 16820217 |doi= 10.1016/j.jneuroim.2006.05.018

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes