MSR1

Macrophage scavenger receptor 1, also known as MSR1, is a human gene.cite web | title = Entrez Gene: MSR1 macrophage scavenger receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4481| accessdate = ]

MSR1 has also recently been designated CD204 (cluster of differentiation 204).

PBB_Summary
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summary_text = This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.cite web | title = Entrez Gene: MSR1 macrophage scavenger receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4481| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Asaoka H, Matsumoto A, Itakura H, Kodama T |title= [Structural and function of the human macrophage scavenger receptor] |journal=Nippon Rinsho |volume=51 |issue= 6 |pages= 1677–83 |year= 1993 |pmid= 8391600 |doi=
*cite journal | author=Naito M, Suzuki H, Mori T, "et al." |title=Coexpression of type I and type II human macrophage scavenger receptors in macrophages of various organs and foam cells in atherosclerotic lesions. |journal=Am. J. Pathol. |volume=141 |issue= 3 |pages= 591–9 |year= 1992 |pmid= 1519666 |doi=
*cite journal | author=Matsumoto A, Naito M, Itakura H, "et al." |title=Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 23 |pages= 9133–7 |year= 1991 |pmid= 2251254 |doi=
*cite journal | author=Emi M, Asaoka H, Matsumoto A, "et al." |title=Structure, organization, and chromosomal mapping of the human macrophage scavenger receptor gene. |journal=J. Biol. Chem. |volume=268 |issue= 3 |pages= 2120–5 |year= 1993 |pmid= 8093617 |doi=
*cite journal | author=Ashkenas J, Penman M, Vasile E, "et al." |title=Structures and high and low affinity ligand binding properties of murine type I and type II macrophage scavenger receptors. |journal=J. Lipid Res. |volume=34 |issue= 6 |pages= 983–1000 |year= 1993 |pmid= 8394868 |doi=
*cite journal | author=Resnick D, Chatterton JE, Schwartz K, "et al." |title=Structures of class A macrophage scavenger receptors. Electron microscopic study of flexible, multidomain, fibrous proteins and determination of the disulfide bond pattern of the scavenger receptor cysteine-rich domain. |journal=J. Biol. Chem. |volume=271 |issue= 43 |pages= 26924–30 |year= 1996 |pmid= 8900177 |doi=
*cite journal | author=Hsu HY, Hajjar DP, Khan KM, Falcone DJ |title=Ligand binding to macrophage scavenger receptor-A induces urokinase-type plasminogen activator expression by a protein kinase-dependent signaling pathway. |journal=J. Biol. Chem. |volume=273 |issue= 2 |pages= 1240–6 |year= 1998 |pmid= 9422792 |doi=
*cite journal | author=Gough PJ, Greaves DR, Gordon S |title=A naturally occurring isoform of the human macrophage scavenger receptor (SR-A) gene generated by alternative splicing blocks modified LDL uptake. |journal=J. Lipid Res. |volume=39 |issue= 3 |pages= 531–43 |year= 1998 |pmid= 9548586 |doi=
*cite journal | author=Teupser D, Thiery J, Seidel D |title=Alpha-tocopherol down-regulates scavenger receptor activity in macrophages. |journal=Atherosclerosis |volume=144 |issue= 1 |pages= 109–15 |year= 1999 |pmid= 10381284 |doi=
*cite journal | author=Nakamura T, Hinagata J, Tanaka T, "et al." |title=HSP90, HSP70, and GAPDH directly interact with the cytoplasmic domain of macrophage scavenger receptors. |journal=Biochem. Biophys. Res. Commun. |volume=290 |issue= 2 |pages= 858–64 |year= 2002 |pmid= 11785981 |doi= 10.1006/bbrc.2001.6271
*cite journal | author=Tomokiyo R, Jinnouchi K, Honda M, "et al." |title=Production, characterization, and interspecies reactivities of monoclonal antibodies against human class A macrophage scavenger receptors. |journal=Atherosclerosis |volume=161 |issue= 1 |pages= 123–32 |year= 2002 |pmid= 11882324 |doi=
*cite journal | author=Xu J, Zheng SL, Komiya A, "et al." |title=Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk. |journal=Nat. Genet. |volume=32 |issue= 2 |pages= 321–5 |year= 2002 |pmid= 12244320 |doi= 10.1038/ng994
*cite journal | author=Xu J, Zheng SL, Komiya A, "et al." |title=Common sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk. |journal=Am. J. Hum. Genet. |volume=72 |issue= 1 |pages= 208–12 |year= 2003 |pmid= 12471593 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kosswig N, Rice S, Daugherty A, Post SR |title=Class A scavenger receptor-mediated adhesion and internalization require distinct cytoplasmic domains. |journal=J. Biol. Chem. |volume=278 |issue= 36 |pages= 34219–25 |year= 2003 |pmid= 12819208 |doi= 10.1074/jbc.M303465200
*cite journal | author=Miller DC, Zheng SL, Dunn RL, "et al." |title=Germ-line mutations of the macrophage scavenger receptor 1 gene: association with prostate cancer risk in African-American men. |journal=Cancer Res. |volume=63 |issue= 13 |pages= 3486–9 |year= 2003 |pmid= 12839931 |doi=
*cite journal | author=Wang L, McDonnell SK, Cunningham JM, "et al." |title=No association of germline alteration of MSR1 with prostate cancer risk. |journal=Nat. Genet. |volume=35 |issue= 2 |pages= 128–9 |year= 2003 |pmid= 12958598 |doi= 10.1038/ng1239
*cite journal | author=Nupponen NN, Wallén MJ, Ponciano D, "et al." |title=Mutational analysis of susceptibility genes RNASEL/HPC1, ELAC2/HPC2, and MSR1 in sporadic prostate cancer. |journal=Genes Chromosomes Cancer |volume=39 |issue= 2 |pages= 119–25 |year= 2004 |pmid= 14695991 |doi= 10.1002/gcc.10308
*cite journal | author=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance. |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8

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