- CD32
protein
Name= Fc fragment of IgG, low affinity IIa, receptor (CD32)
caption=
width=
HGNCid=3616
Symbol=FCGR2A
AltSymbols=FCG2, FCGR2A1, FCGR2
EntrezGene=2212
OMIM=146790
RefSeq=NM_021642
UniProt=P12318
PDB=
ECnumber=
Chromosome=1
Arm=q
Band=23
LocusSupplementaryData=protein
Name= Fc fragment of IgG, low affinity IIb, receptor (CD32)
caption=
width=
HGNCid=3618
Symbol=FCGR2B
AltSymbols=FCG2, FCGR2
EntrezGene=2213
OMIM=604590
RefSeq=NM_004001
UniProt=P31994
PDB=
ECnumber=
Chromosome=1
Arm=q
Band=23
LocusSupplementaryData=protein
Name=Fc fragment of IgG, low affinity IIb, receptor for (CD32)
caption=
width=
HGNCid=15626
Symbol=FCGR2C
AltSymbols=
EntrezGene=9103
OMIM=
RefSeq=NM_201563
UniProt=P31995
PDB=
ECnumber=
Chromosome=1
Arm=q
Band=23
LocusSupplementaryData=CD32 is a surface receptor protein and part of a large population of
B cell co-receptors, which act to modulate signalling.It has a low-affinity for
IgG antibodies and down-regulates antibody production in the presence of IgG. This feedback loops essentially lowers the production of IgG produced by B cells when there is a surplus in the body. [Coico, R., Sunshine, G., and Benjamin, E. (2003). "Immunology: A Short Course" p.97.]Monoclonal antibodies can distinguish between type A and type B.cite journal |author=Veri MC, Gorlatov S, Li H, "et al" |title=Monoclonal antibodies capable of discriminating the human inhibitory Fcgamma-receptor IIB (CD32B) from the activating Fcgamma-receptor IIA (CD32A): biochemical, biological and functional characterization |journal=Immunology |volume=121 |issue=3 |pages=392–404 |year=2007 |pmid=17386079 |doi=10.1111/j.1365-2567.2007.02588.x]
External links
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References
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