KLRC2

Killer cell lectin-like receptor subfamily C, member 2, also known as KLRC2, is a human gene.cite web | title = Entrez Gene: KLRC2 killer cell lectin-like receptor subfamily C, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3822| accessdate = ]

PBB_Summary
section_title =
summary_text = Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined.cite web | title = Entrez Gene: KLRC2 killer cell lectin-like receptor subfamily C, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3822| accessdate = ]

ee also

* Cluster of differentiation

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Houchins JP, Yabe T, McSherry C, Bach FH |title=DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. |journal=J. Exp. Med. |volume=173 |issue= 4 |pages= 1017–20 |year= 1991 |pmid= 2007850 |doi=
*cite journal | author=Yabe T, McSherry C, Bach FH, "et al." |title=A multigene family on human chromosome 12 encodes natural killer-cell lectins. |journal=Immunogenetics |volume=37 |issue= 6 |pages= 455–60 |year= 1993 |pmid= 8436421 |doi=
*cite journal | author=Houchins JP, Lanier LL, Niemi EC, "et al." |title=Natural killer cell cytolytic activity is inhibited by NKG2-A and activated by NKG2-C. |journal=J. Immunol. |volume=158 |issue= 8 |pages= 3603–9 |year= 1997 |pmid= 9103421 |doi=
*cite journal | author=Braud VM, Allan DS, O'Callaghan CA, "et al." |title=HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C. |journal=Nature |volume=391 |issue= 6669 |pages= 795–9 |year= 1998 |pmid= 9486650 |doi= 10.1038/35869
*cite journal | author=Plougastel B, Trowsdale J |title=Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes. |journal=Genomics |volume=49 |issue= 2 |pages= 193–9 |year= 1998 |pmid= 9598306 |doi= 10.1006/geno.1997.5197
*cite journal | author=Lanier LL, Corliss B, Wu J, Phillips JH |title=Association of DAP12 with activating CD94/NKG2C NK cell receptors. |journal=Immunity |volume=8 |issue= 6 |pages= 693–701 |year= 1998 |pmid= 9655483 |doi=
*cite journal | author=Glienke J, Sobanov Y, Brostjan C, "et al." |title=The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex. |journal=Immunogenetics |volume=48 |issue= 3 |pages= 163–73 |year= 1998 |pmid= 9683661 |doi=
*cite journal | author=Ding Y, Sumitran S, Holgersson J |title=Direct binding of purified HLA class I antigens by soluble NKG2/CD94 C-type lectins from natural killer cells. |journal=Scand. J. Immunol. |volume=49 |issue= 5 |pages= 459–65 |year= 1999 |pmid= 10320637 |doi=
*cite journal | author=Khakoo SI, Rajalingam R, Shum BP, "et al." |title=Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans. |journal=Immunity |volume=12 |issue= 6 |pages= 687–98 |year= 2000 |pmid= 10894168 |doi=
*cite journal | author=Shum BP, Flodin LR, Muir DG, "et al." |title=Conservation and variation in human and common chimpanzee CD94 and NKG2 genes. |journal=J. Immunol. |volume=168 |issue= 1 |pages= 240–52 |year= 2002 |pmid= 11751968 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hikami K, Tsuchiya N, Yabe T, Tokunaga K |title=Variations of human killer cell lectin-like receptors: common occurrence of NKG2-C deletion in the general population. |journal=Genes Immun. |volume=4 |issue= 2 |pages= 160–7 |year= 2003 |pmid= 12618865 |doi= 10.1038/sj.gene.6363940
*cite journal | author=Miyashita R, Tsuchiya N, Hikami K, "et al." |title=Molecular genetic analyses of human NKG2C (KLRC2) gene deletion. |journal=Int. Immunol. |volume=16 |issue= 1 |pages= 163–8 |year= 2004 |pmid= 14688071 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ortega C, Romero P, Palma A, "et al." |title=Role for NKG2-A and NKG2-C surface receptors in chronic CD4+ T-cell responses. |journal=Immunol. Cell Biol. |volume=82 |issue= 6 |pages= 587–95 |year= 2005 |pmid= 15550116 |doi= 10.1111/j.0818-9641.2004.01284.x
*cite journal | author=Gumá M, Busch LK, Salazar-Fontana LI, "et al." |title=The CD94/NKG2C killer lectin-like receptor constitutes an alternative activation pathway for a subset of CD8+ T cells. |journal=Eur. J. Immunol. |volume=35 |issue= 7 |pages= 2071–80 |year= 2005 |pmid= 15940674 |doi= 10.1002/eji.200425843

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