Leptin receptor

Leptin receptor
Leptin receptor
Symbols LEPR; CD295; DKFZp686B1731; LEP-R; OB-R; OBR
External IDs OMIM601007 MGI104993 HomoloGene1731 GeneCards: LEPR Gene
Species Human Mouse
Entrez 3953 16847
Ensembl ENSG00000116678 ENSMUSG00000057722
UniProt P48357 P48356
RefSeq (mRNA) NM_001003679.3 NM_010704
RefSeq (protein) NP_001003679.1 NP_034834
Location (UCSC) Chr 1:
65.89 – 66.11 Mb
Chr 4:
101.39 – 101.49 Mb
PubMed search [1] [2]

Leptin receptor also known as LEP-R is a protein that in humans is encoded by the LEPR gene.[1][2] LEP-R functions as a receptor for the fat cell-specific hormone leptin. LEP-R has also been designated as CD295 (cluster of differentiation 295).



The leptin hormone regulates adipose-tissue mass through hypothalamus effects on fullness and energy use, acts through the leptin receptor (LEP-R), a single-transmembrane-domain receptor of the cytokine receptor family.[3]

Clinical significance

Variations in the leptin receptor have been associated with obesity.[4]

Animals models

The db/db mouse is a model of obesity, diabetes, and dyslipidemia wherein leptin receptor activity is deficient because the mice are homozygous for a point mutation in the gene for the leptin receptor.[5] In db/db mice, induced swimming helped to overcome obesity by upregulating uncoupling proteins.[6]


  1. ^ Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Wool EA, Monroe CA, Tepper RI (Feb 1996). "Identification and expression cloning of a leptin receptor, OB-R". Cell 83 (7): 1263–71. doi:10.1016/0092-8674(95)90151-5. PMID 8548812. 
  2. ^ Winick JD, Stoffel M, Friedman JM (Feb 1997). "Identification of microsatellite markers linked to the human leptin receptor gene on chromosome 1". Genomics 36 (1): 221–2. doi:10.1006/geno.1996.0455. PMID 8812446. 
  3. ^ "Entrez Gene: LEPR leptin receptor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3953. 
  4. ^ Masuo K, Straznicky NE, Lambert GW, Katsuya T, Sugimoto K, Rakugi H, Socratous F, Hastings J, Lambert EA, Ogihara T, Esler MD (June 2008). "Leptin-receptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic nerve activation in a Caucasian male population". Hypertens. Res. 31 (6): 1093–100. doi:10.1291/hypres.31.1093. PMID 18716356. 
  5. ^ Sharma K, McCue P, Dunn SR (June 2003). "Diabetic kidney disease in the db/db mouse". Am. J. Physiol. Renal Physiol. 284 (6): F1138–44. doi:10.1152/ajprenal.00315.2002. PMID 12736165. 
  6. ^ Oh KS, Kim EY, Yoon M, Lee CM (June 2007). "Swim training improves leptin receptor deficiency-induced obesity and lipid disorder by activating uncoupling proteins". Exp. Mol. Med. 39 (3): 385–94. PMID 17603293. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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