Uncoupling protein

Uncoupling protein

An uncoupling protein is a mitochondrial inner membrane protein that can dissipate the proton gradient before it can be used to provide the energy for oxidative phosphorylation.cite journal |author=Nedergaard J, Ricquier D, Kozak LP |title=Uncoupling proteins: current status and therapeutic prospects |journal=EMBO Rep. |volume=6 |issue=10 |pages=917–21 |year=2005 |pmid=16179945 |doi=10.1038/sj.embor.7400532]

There are five types known in mammals:
* UCP1, also known as thermogenin
* UCP2
* UCP3
* SLC25A27, also known as "UCP4"
* SLC25A14, also known as "UCP5"

Uncoupling proteins play a role in normal physiology, as in hibernation, because the energy is used to generate heat (see thermogenesis) instead of producing ATP. However, other substances such as 2,4-Dinitrophenol and CCCP also serve the same uncoupling function, and are considered poisonous. Ethanol and salicyclic acid are also uncoupling agents and will deplete the body of ATP and increase body temperature if taken in excess.

References

External links

*


Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Look at other dictionaries:

  • Uncoupling Protein — 1 (mitochondrial, proton carrier) Größe 307 Aminosäuren Struktur multipass Membranprotein Bezeichner …   Deutsch Wikipedia

  • uncoupling protein — a protein that occurs in the inner membrane of the mitochondria of brown adipose tissue, important in nonshivering thermogenesis; it dissipates the proton gradient created by the respiratory chain, thus uncoupling oxidation from phosphorylation… …   Medical dictionary

  • Mitochondrial trifunctional protein — Schematic demonstrating mitochondrial fatty acid beta oxidation and effects of long chain 3 hydroxyacyl coenzyme A dehydrogenase deficiency, LCHAD deficiency Mitochondrial trifunctional protein is a protein which catalyzes several reactions in… …   Wikipedia

  • Mitochondrial membrane transport protein — Mitochondrial membrane transport proteins are proteins which exist in the membranes of mitochondria and which serve to transport[1] molecules and other factors such as ions into or out of the organelles. Examples Examples of mitochondrial… …   Wikipedia

  • G protein-coupled receptor — G protein coupled receptors (GPCRs), also known as seven transmembrane domain receptors, 7TM receptors, heptahelical receptors, and G protein linked receptors (GPLR), comprise a large protein family of transmembrane receptors that sense molecules …   Wikipedia

  • UCP3 — Uncoupling protein 3 (mitochondrial, proton carrier), also known as UCP3, is a human gene.cite journal | author = Vidal Puig A, Solanes G, Grujic D, Flier JS, Lowell BB | title = UCP3: an uncoupling protein homologue expressed preferentially and… …   Wikipedia

  • UCP2 — Uncoupling protein 2 (mitochondrial, proton carrier), also known as UCP2, is a human gene. PBB Summary section title = summary text = Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins …   Wikipedia

  • Thermogenin — uncoupling protein 1 (mitochondrial, proton carrier) Masse/Länge Primärstruktur 307 Aminosäuren …   Deutsch Wikipedia

  • UCP — uncoupling protein; urinary coproporphyrin; urinary C peptide …   Medical dictionary

  • UCP — • uncoupling protein; • urinary coproporphyrin; • urinary C peptide …   Dictionary of medical acronyms & abbreviations

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”