CD14

Cluster of differentiation 14 also known as CD14 is a human gene.cite journal | author = Setoguchi M, Nasu N, Yoshida S, Higuchi Y, Akizuki S, Yamamoto S | title = Mouse and human CD14 (myeloid cell-specific leucine-rich glycoprotein) primary structure deduced from cDNA clones | journal = Biochim. Biophys. Acta | volume = 1008 | issue = 2 | pages = 213–22 | year = 1989 | month = July | pmid = 2472171 | doi = 10.1016/0167-4781(80)90012-3 | url = | issn = ] cite journal | author = Simmons DL, Tan S, Tenen DG, Nicholson-Weller A, Seed B | title = Monocyte antigen CD14 is a phospholipid anchored membrane protein | journal = Blood | volume = 73 | issue = 1 | pages = 284–9 | year = 1989 | month = January | pmid = 2462937 | url = http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=2462937 | issn = ]

The protein encoded by this gene is a component of the innate immune system. CD14 exists in two forms. It is either anchored into the membrane by a a glycosylphosphatidylinositol tail (mCD14) or it appears in a soluble form (sCD14). Soluble CD14 appears either after shedding of mCD14 (48 KDa) or is directly secreted from intracellular vesicles (56 KDa).cite journal | author = Kirkland TN, Viriyakosol S | title = Structure-function analysis of soluble and membrane-bound CD14 | journal = Prog. Clin. Biol. Res. | volume = 397 | issue = | pages = 79–87 | year = 1998 | pmid = 9575549 | doi = | url = | issn = ]

CD14 takes its name from its inclusion in the cluster of differentiation group of cell surface marker proteins.

CD14 was the first described pattern recognition receptor.

Function

CD14 acts as a co-receptor (along with the Toll-like receptor TLR 4 and MD-2) for the detection of bacterial lipopolysaccharide (LPS).cite journal | author = Kitchens RL | title = Role of CD14 in cellular recognition of bacterial lipopolysaccharides | journal = Chem. Immunol. | volume = 74 | issue = | pages = 61–82 | year = 2000 | pmid = 10608082 | url = | issn = ] cite journal | author = Tapping RI, Tobias PS | title = Soluble CD14-mediated cellular responses to lipopolysaccharide | journal = Chem. Immunol. | volume = 74 | issue = | pages = 108–21 | year = 2000 | pmid = 10608084 | doi = | url = | issn = ] CD14 can only bind LPS in the presence of lipopolysaccharide-binding protein (LBP).Although LPS is considered it's main ligand CD14 also recognizes other pathogen associated molecular patterns.

Tissue distribution

CD14 is expressed mainly by macrophages and (at 10 times lesser extent) by neutrophil granulocytes. A soluble form sCD14 is secreted by the liver and monocytes and is sufficient in low concentrations to confer LPS-responsiveness to cells which otherwise do not express CD14.

Differentiation

CD14+ are monocytes that can differentiate into a host of different cells. (A '+' sign refers to the presence of the CD14 protein on a cell. )

One type of cell is the dendritic cell, where differentiation is encouraged by cytokines. Examples of cytokines that will cause dendritic cell differentiation includes GM-CSF and IL-4.

External links

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References

Further reading

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*cite journal | author=Todd RF, Petty HR |title=Beta 2 (CD11/CD18) integrins can serve as signaling partners for other leukocyte receptors. |journal=J. Lab. Clin. Med. |volume=129 |issue= 5 |pages= 492–8 |year= 1997 |pmid= 9142045 |doi=

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