TGF beta 2

TGF beta 2

Transforming growth factor-beta 2 (TGF-β2) is a secreted protein known as a cytokine that performs many cellular functions and has a vital role during embryonic development (alternative names: Glioblastoma-derived T-cell suppressor factor, G-TSF, BSC-1 cell growth inhibitor, Polyergin, Cetermin). It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors. There are two named isoforms of this protein, created by alternative splicing of the same gene.

Further reading

citations =
*cite journal | author=Clark DA, Coker R |title=Transforming growth factor-beta (TGF-beta). |journal=Int. J. Biochem. Cell Biol. |volume=30 |issue= 3 |pages= 293–8 |year= 1998 |pmid= 9611771 |doi=
*cite journal | author=Wick W, Platten M, Weller M |title=Glioma cell invasion: regulation of metalloproteinase activity by TGF-beta. |journal=J. Neurooncol. |volume=53 |issue= 2 |pages= 177–85 |year= 2002 |pmid= 11716069 |doi=
*cite journal | author=Bissell DM |title=Chronic liver injury, TGF-beta, and cancer. |journal=Exp. Mol. Med. |volume=33 |issue= 4 |pages= 179–90 |year= 2002 |pmid= 11795478 |doi=
*cite journal | author=Kalluri R, Neilson EG |title=Epithelial-mesenchymal transition and its implications for fibrosis. |journal=J. Clin. Invest. |volume=112 |issue= 12 |pages= 1776–84 |year= 2004 |pmid= 14679171 |doi= 10.1172/JCI200320530
*cite journal | author=Daopin S, Piez KA, Ogawa Y, Davies DR |title=Crystal structure of transforming growth factor-beta 2: an unusual fold for the superfamily. |journal=Science |volume=257 |issue= 5068 |pages= 369–73 |year= 1992 |pmid= 1631557 |doi=
*cite journal | author=Schlunegger MP, Grütter MG |title=An unusual feature revealed by the crystal structure at 2.2 A resolution of human transforming growth factor-beta 2. |journal=Nature |volume=358 |issue= 6385 |pages= 430–4 |year= 1992 |pmid= 1641027 |doi= 10.1038/358430a0
*cite journal | author=Noma T, Glick AB, Geiser AG, "et al." |title=Molecular cloning and structure of the human transforming growth factor-beta 2 gene promoter. |journal=Growth Factors |volume=4 |issue= 4 |pages= 247–55 |year= 1992 |pmid= 1764261 |doi=
*cite journal | author=Bodmer S, Podlisny MB, Selkoe DJ, "et al." |title=Transforming growth factor-beta bound to soluble derivatives of the beta amyloid precursor protein of Alzheimer's disease. |journal=Biochem. Biophys. Res. Commun. |volume=171 |issue= 2 |pages= 890–7 |year= 1990 |pmid= 2119582 |doi=
*cite journal | author=Webb NR, Madisen L, Rose TM, Purchio AF |title=Structural and sequence analysis of TGF-beta 2 cDNA clones predicts two different precursor proteins produced by alternative mRNA splicing. |journal=DNA |volume=7 |issue= 7 |pages= 493–7 |year= 1989 |pmid= 2850146 |doi=
*cite journal | author=Madisen L, Webb NR, Rose TM, "et al." |title=Transforming growth factor-beta 2: cDNA cloning and sequence analysis. |journal=DNA |volume=7 |issue= 1 |pages= 1–8 |year= 1988 |pmid= 3162414 |doi=
*cite journal | author=Barton DE, Foellmer BE, Du J, "et al." |title=Chromosomal mapping of genes for transforming growth factors beta 2 and beta 3 in man and mouse: dispersion of TGF-beta gene family. |journal=Oncogene Res. |volume=3 |issue= 4 |pages= 323–31 |year= 1989 |pmid= 3226728 |doi=
*cite journal | author=de Martin R, Haendler B, Hofer-Warbinek R, "et al." |title=Complementary DNA for human glioblastoma-derived T cell suppressor factor, a novel member of the transforming growth factor-beta gene family. |journal=EMBO J. |volume=6 |issue= 12 |pages= 3673–7 |year= 1988 |pmid= 3322813 |doi=
*cite journal | author=Marquardt H, Lioubin MN, Ikeda T |title=Complete amino acid sequence of human transforming growth factor type beta 2. |journal=J. Biol. Chem. |volume=262 |issue= 25 |pages= 12127–31 |year= 1987 |pmid= 3476488 |doi=
*cite journal | author=Philip A, Bostedt L, Stigbrand T, O'Connor-McCourt MD |title=Binding of transforming growth factor-beta (TGF-beta) to pregnancy zone protein (PZP). Comparison to the TGF-beta-alpha 2-macroglobulin interaction. |journal=Eur. J. Biochem. |volume=221 |issue= 2 |pages= 687–93 |year= 1994 |pmid= 7513640 |doi=
*cite journal | author=Lin HY, Moustakas A, Knaus P, "et al." |title=The soluble exoplasmic domain of the type II transforming growth factor (TGF)-beta receptor. A heterogeneously glycosylated protein with high affinity and selectivity for TGF-beta ligands. |journal=J. Biol. Chem. |volume=270 |issue= 6 |pages= 2747–54 |year= 1995 |pmid= 7852346 |doi=
*cite journal | author=Hildebrand A, Romarís M, Rasmussen LM, "et al." |title=Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta. |journal=Biochem. J. |volume=302 ( Pt 2) |issue= |pages= 527–34 |year= 1994 |pmid= 8093006 |doi=
*cite journal | author=López-Casillas F, Payne HM, Andres JL, Massagué J |title=Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites. |journal=J. Cell Biol. |volume=124 |issue= 4 |pages= 557–68 |year= 1994 |pmid= 8106553 |doi=
*cite journal | author=Fromigué O, Marie PJ, Lomri A |title=Bone morphogenetic protein-2 and transforming growth factor-beta2 interact to modulate human bone marrow stromal cell proliferation and differentiation. |journal=J. Cell. Biochem. |volume=68 |issue= 4 |pages= 411–26 |year= 1998 |pmid= 9493905 |doi=
*cite journal | author=Mori T, Kawara S, Shinozaki M, "et al." |title=Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis model. |journal=J. Cell. Physiol. |volume=181 |issue= 1 |pages= 153–9 |year= 1999 |pmid= 10457363 |doi= 10.1002/(SICI)1097-4652(199910)181:1<153::AID-JCP16>3.0.CO;2-K |doilabel=10.1002/(SICI)1097-4652(199910)181:1153::AID-JCP163.0.CO;2-K

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