- Cyclin E
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cyclin E1 Identifiers Symbol CCNE1 Alt. symbols CCNE Entrez 898 HUGO 1589 OMIM 123837 RefSeq NM_001238 UniProt P24864 Other data Locus Chr. 19 q12 cyclin E2 Identifiers Symbol CCNE2 Entrez 9134 HUGO 1590 OMIM 603775 RefSeq NM_057749 UniProt O96020 Other data Locus Chr. 8 q22.1 Cyclin E is a member of the cyclin family.
Cyclin E binds to G1 phase Cdk2, which is required for the transition from G1 to S phase. The Cyclin E/CDK2 complex phosphorylates p27Kip1 (an inhibitor of Cyclin D), tagging it for degradation, thus promoting expression of Cyclin A, allowing progression to S phase.
External links
Cell cycle proteins Cyclin CDK CDK inhibitor P53 p63 p73 family Phases and
checkpointsOther cellular phasesB bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°) Categories:- Genes on chromosome 19
- Genes on chromosome 8
- Cell biology stubs
- Cell cycle
- Proteins
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