- Cyclin B
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Structure of human cyclin B.[1]
cyclin B1 Identifiers Symbol CCNB1 Alt. symbols CCNB Entrez 891 HUGO 1579 OMIM 123836 RefSeq NM_031966 UniProt P14635 Other data Locus Chr. 5 q12 cyclin B2 Identifiers Symbol CCNB2 Entrez 9133 HUGO 1580 OMIM 602755 RefSeq NM_004701 UniProt O95067 Other data Locus Chr. 15 q21.3 cyclin B3 Identifiers Symbol CCNB3 Entrez 85417 HUGO 18709 OMIM 300456 RefSeq NM_033670 UniProt Q8WWL7 Other data Locus Chr. X p11 Cyclin B is a member of the cyclin family.
Cyclin B is a mitotic cyclin. The amount of cyclin B (which binds to Cdk1) and the activity of the cyclin B-Cdk complex rise through the cell cycle[2] until mitosis, where they fall abruptly due to degradation of cyclin B (Cdk1 is constitutively present).[3] The complex of Cdk and cyclin B is called maturation promoting factor or mitosis promoting factor (MPF).
See also
References
- ^ Petri, E.T., Errico, A., Escobedo, L., Hunt, T., and Basavappa, R. (2007). "The crystal structure of human cyclin B". Cell Cycle 11 (11): 1342–9. PMID 17495533.
- ^ Ito M (August 2000). "Factors controlling cyclin B expression". Plant Mol. Biol. 43 (5-6): 677–90. doi:10.1023/A:1006336005587. PMID 11089869. http://www.kluweronline.com/art.pdf?issn=0167-4412&volume=43&page=677.
- ^ Hershko A (September 1999). "Mechanisms and regulation of the degradation of cyclin B". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 354 (1389): 1571–5; discussion 1575–6. doi:10.1098/rstb.1999.0500. PMC 1692665. PMID 10582242. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1692665.
External links
Cell cycle proteins Cyclin CDK CDK inhibitor P53 p63 p73 family Phases and
checkpointsOther cellular phasesB bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°) Categories:- Genes on chromosome 5
- Genes on chromosome 15
- Genes on chromosome X
- Cell cycle
- Proteins
- Cell biology stubs
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