Cyclin B2

Cyclin B2
Identifiers
Symbols	CCNB2; HsT17299
External IDs	OMIM: 602755 MGI: 88311 HomoloGene: 74359 GeneCards: CCNB2 Gene
Gene Ontology Molecular function • protein binding • protein kinase binding Cellular component • membrane fraction • nucleus • centrosome • cytosol • cytosol • microtubule cytoskeleton Biological process • cell cycle checkpoint • regulation of cyclin-dependent protein kinase activity • G2/M transition of mitotic cell cycle • mitotic cell cycle • in utero embryonic development • mitosis • regulation of G2/M transition of mitotic cell cycle • growth • T cell homeostasis • thymus development • cell division Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9133	12442
Ensembl	ENSG00000157456	ENSMUSG00000032218
UniProt	O95067	Q922E9
RefSeq (mRNA)	NM_004701.3	NM_007630.2
RefSeq (protein)	NP_004692.1	NP_031656.2
Location (UCSC)	Chr 15: 59.4 – 59.42 Mb	Chr 9: 70.26 – 70.27 Mb
PubMed search	[1]	[2]

G2/mitotic-specific cyclin-B2 is a protein that in humans is encoded by the CCNB2 gene.

Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control.^[1]

See also

• Cyclin B

Interactions

Cyclin B2 has been shown to interact with TGF beta receptor 2.^[2]

References

1. ^ "Entrez Gene: CCNB2 cyclin B2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9133. 
2. ^ Liu, J H; Wei S, Burnette P K, Gamero A M, Hutton M, Djeu J Y (Jan. 1999). "Functional association of TGF-beta receptor II with cyclin B". Oncogene (ENGLAND) 18 (1): 269–75. doi:10.1038/sj.onc.1202263. ISSN 0950-9232. PMID 9926943. 

Further reading

• He J, Choe S, Walker R, et al. (1995). "Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity.". J. Virol. 69 (11): 6705–11. PMC 189580. PMID 7474080. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=189580. 
• Re F, Braaten D, Franke EK, Luban J (1995). "Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B.". J. Virol. 69 (11): 6859–64. PMC 189600. PMID 7474100. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=189600. 
• Di Marzio P, Choe S, Ebright M, et al. (1996). "Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr.". J. Virol. 69 (12): 7909–16. PMC 189735. PMID 7494303. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=189735. 
• Jowett JB, Planelles V, Poon B, et al. (1995). "The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle.". J. Virol. 69 (10): 6304–13. PMC 189529. PMID 7666531. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=189529. 
• Jackman M, Firth M, Pines J (1995). "Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 primarily to the Golgi apparatus.". EMBO J. 14 (8): 1646–54. PMC 398257. PMID 7737117. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=398257. 
• Pines J, Hunter T (1994). "The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B.". EMBO J. 13 (16): 3772–81. PMC 395290. PMID 8070405. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=395290. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Poon B, Jowett JB, Stewart SA, et al. (1997). "Human immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustard.". J. Virol. 71 (5): 3961–71. PMC 191548. PMID 9094673. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=191548. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Mahalingam S, Ayyavoo V, Patel M, et al. (1998). "HIV-1 Vpr interacts with a human 34-kDa mov34 homologue, a cellular factor linked to the G2/M phase transition of the mammalian cell cycle.". Proc. Natl. Acad. Sci. U.S.A. 95 (7): 3419–24. doi:10.1073/pnas.95.7.3419. PMC 19851. PMID 9520381. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=19851. 
• Brandeis M, Rosewell I, Carrington M, et al. (1998). "Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero.". Proc. Natl. Acad. Sci. U.S.A. 95 (8): 4344–9. doi:10.1073/pnas.95.8.4344. PMC 22491. PMID 9539739. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=22491. 
• Felzien LK, Woffendin C, Hottiger MO, et al. (1998). "HIV transcriptional activation by the accessory protein, VPR, is mediated by the p300 co-activator.". Proc. Natl. Acad. Sci. U.S.A. 95 (9): 5281–6. doi:10.1073/pnas.95.9.5281. PMC 20252. PMID 9560267. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=20252. 
• Liu JH, Wei S, Burnette PK, et al. (1999). "Functional association of TGF-beta receptor II with cyclin B.". Oncogene 18 (1): 269–75. doi:10.1038/sj.onc.1202263. PMID 9926943. 
• Hrimech M, Yao XJ, Branton PE, Cohen EA (2000). "Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A.". EMBO J. 19 (15): 3956–67. doi:10.1093/emboj/19.15.3956. PMC 306605. PMID 10921877. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=306605. 
• Elder RT, Yu M, Chen M, et al. (2000). "Cell cycle G2 arrest induced by HIV-1 Vpr in fission yeast (Schizosaccharomyces pombe) is independent of cell death and early genes in the DNA damage checkpoint.". Virus Res. 68 (2): 161–73. doi:10.1016/S0168-1702(00)00167-2. PMID 10958988. 
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948. 
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072. 
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1083732. 
• Elder RT, Yu M, Chen M, et al. (2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25.". Virology 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413. 
• Mouland AJ, Coady M, Yao XJ, Cohen EA (2002). "Hypophosphorylation of poly(A) polymerase and increased polyadenylation activity are associated with human immunodeficiency virus type 1 Vpr expression.". Virology 292 (2): 321–30. doi:10.1006/viro.2001.1261. PMID 11878934.