CDKN2C

Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4), also known as CDKN2C, is a human gene.cite web | title = Entrez Gene: CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1031| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.cite web | title = Entrez Gene: CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1031| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Guan KL, Jenkins CW, Li Y, "et al." |title=Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. |journal=Genes Dev. |volume=8 |issue= 24 |pages= 2939–52 |year= 1995 |pmid= 8001816 |doi=
*cite journal | author=Serrano M, Hannon GJ, Beach D |title=A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. |journal=Nature |volume=366 |issue= 6456 |pages= 704–7 |year= 1994 |pmid= 8259215 |doi= 10.1038/366704a0
*cite journal | author=Ghosh PK, Anderson J, Cohen N, "et al." |title=Expression of the leukemia-associated gene, p18, in normal and malignant tissues; inactivation of expression in a patient with cleaved B cell lymphoma/leukemia. |journal=Oncogene |volume=8 |issue= 10 |pages= 2869–72 |year= 1993 |pmid= 8397372 |doi=
*cite journal | author=Simos G, Maison C, Georgatos SD |title=Characterization of p18, a component of the lamin B receptor complex and a new integral membrane protein of the avian erythrocyte nuclear envelope. |journal=J. Biol. Chem. |volume=271 |issue= 21 |pages= 12617–25 |year= 1996 |pmid= 8647873 |doi=
*cite journal | author=Ragione FD, Russo GL, Oliva A, "et al." |title=Biochemical characterization of p16INK4- and p18-containing complexes in human cell lines. |journal=J. Biol. Chem. |volume=271 |issue= 27 |pages= 15942–9 |year= 1996 |pmid= 8663131 |doi=
*cite journal | author=Lapointe J, Lachance Y, Labrie Y, Labrie C |title=A p18 mutant defective in CDK6 binding in human breast cancer cells. |journal=Cancer Res. |volume=56 |issue= 20 |pages= 4586–9 |year= 1996 |pmid= 8840966 |doi=
*cite journal | author=Venkataramani R, Swaminathan K, Marmorstein R |title=Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations. |journal=Nat. Struct. Biol. |volume=5 |issue= 1 |pages= 74–81 |year= 1998 |pmid= 9437433 |doi=
*cite journal | author=Fåhraeus R, Laín S, Ball KL, Lane DP |title=Characterization of the cyclin-dependent kinase inhibitory domain of the INK4 family as a model for a synthetic tumour suppressor molecule. |journal=Oncogene |volume=16 |issue= 5 |pages= 587–96 |year= 1998 |pmid= 9482104 |doi= 10.1038/sj.onc.1201580
*cite journal | author=Iolascon A, Giordani L, Moretti A, "et al." |title=Analysis of CDKN2A, CDKN2B, CDKN2C, and cyclin Ds gene status in hepatoblastoma. |journal=Hepatology |volume=27 |issue= 4 |pages= 989–95 |year= 1998 |pmid= 9537438 |doi= 10.1002/hep.510270414
*cite journal | author=Blais A, Labrie Y, Pouliot F, "et al." |title=Structure of the gene encoding the human cyclin-dependent kinase inhibitor p18 and mutational analysis in breast cancer. |journal=Biochem. Biophys. Res. Commun. |volume=247 |issue= 1 |pages= 146–53 |year= 1998 |pmid= 9636670 |doi= 10.1006/bbrc.1998.8497
*cite journal | author=Noh SJ, Li Y, Xiong Y, Guan KL |title=Identification of functional elements of p18INK4C essential for binding and inhibition of cyclin-dependent kinase (CDK) 4 and CDK6. |journal=Cancer Res. |volume=59 |issue= 3 |pages= 558–64 |year= 1999 |pmid= 9973200 |doi=
*cite journal | author=Li J, Byeon IJ, Ericson K, "et al." |title=Tumor suppressor INK4: determination of the solution structure of p18INK4C and demonstration of the functional significance of loops in p18INK4C and p16INK4A. |journal=Biochemistry |volume=38 |issue= 10 |pages= 2930–40 |year= 1999 |pmid= 10074345 |doi= 10.1021/bi982286e
*cite journal | author=Schreiber M, Muller WJ, Singh G, Graham FL |title=Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity. |journal=Oncogene |volume=18 |issue= 9 |pages= 1663–76 |year= 1999 |pmid= 10208428 |doi= 10.1038/sj.onc.1202466
*cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, "et al." |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=
*cite journal | author=Korshunov A, Golanov A |title=Immunohistochemical analysis of p18INK4C and p14ARF protein expression in 117 oligodendrogliomas: correlation with tumor grade and clinical outcome. |journal=Arch. Pathol. Lab. Med. |volume=126 |issue= 1 |pages= 42–8 |year= 2002 |pmid= 11800646 |doi=
*cite journal | author=Blais A, Monté D, Pouliot F, Labrie C |title=Regulation of the human cyclin-dependent kinase inhibitor p18INK4c by the transcription factors E2F1 and Sp1. |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 31679–93 |year= 2002 |pmid= 12077144 |doi= 10.1074/jbc.M204554200
*cite journal | author=Arcellana-Panlilio MY, Egeler RM, Ujack E, "et al." |title=Evidence of a role for the INK4 family of cyclin-dependent kinase inhibitors in ovarian granulosa cell tumors. |journal=Genes Chromosomes Cancer |volume=35 |issue= 2 |pages= 176–81 |year= 2002 |pmid= 12203782 |doi= 10.1002/gcc.10108
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Komata T, Kanzawa T, Takeuchi H, "et al." |title=Antitumour effect of cyclin-dependent kinase inhibitors (p16(INK4A), p18(INK4C), p19(INK4D), p21(WAF1/CIP1) and p27(KIP1)) on malignant glioma cells. |journal=Br. J. Cancer |volume=88 |issue= 8 |pages= 1277–80 |year= 2004 |pmid= 12698196 |doi= 10.1038/sj.bjc.6600862
*cite journal | author=Sánchez-Aguilera A, Delgado J, Camacho FI, "et al." |title=Silencing of the p18INK4c gene by promoter hypermethylation in Reed-Sternberg cells in Hodgkin lymphomas. |journal=Blood |volume=103 |issue= 6 |pages= 2351–7 |year= 2004 |pmid= 14645011 |doi= 10.1182/blood-2003-07-2356

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