Serpin peptidase inhibitor, clade B (ovalbumin), member 5

PDB rendering based on 1wz9.
Symbols SERPINB5; PI5; maspin
External IDs OMIM154790 MGI109579 HomoloGene20580 GeneCards: SERPINB5 Gene
RNA expression pattern
PBB GE SERPINB5 204855 at tn.png
More reference expression data
Species Human Mouse
Entrez 5268 20724
Ensembl ENSG00000206075 ENSMUSG00000067006
UniProt P36952 Q3ULZ0
RefSeq (mRNA) NM_002639.4 NM_009257.3
RefSeq (protein) NP_002630.2 NP_033283.1
Location (UCSC) Chr 18:
61.14 – 61.17 Mb
Chr 1:
108.76 – 108.78 Mb
PubMed search [1] [2]

Maspin is a serpin and tumor suppressor gene.[1]

It has been associated with prostate cancer and breast cancer.[2]

It has also been associated with tumors of the pancreas.[3]

It was identified in 1994.[4]


  1. ^ Sager R, Sheng S, Pemberton P, Hendrix M (1997). "Maspin. A tumor suppressing serpin". Adv Exp Med Biol 425: 77–88. PMID 9433491. 
  2. ^ Shao LJ, Shi HY, Ayala G, Rowley D, Zhang M (July 2008). "Haploinsufficiency of the maspin tumor suppressor gene leads to hyperplastic lesions in prostate". Cancer Res. 68 (13): 5143–51. doi:10.1158/0008-5472.CAN-08-0163. PMC 2518316. PMID 18593913. 
  3. ^ Kashima K, Ohike N, Mukai S, Sato M, Takahashi M, Morohoshi T (February 2008). "Expression of the tumor suppressor gene maspin and its significance in intraductal papillary mucinous neoplasms of the pancreas". Hbpd Int 7 (1): 86–90. PMID 18234645. 
  4. ^ Khalkhali-Ellis Z (December 2006). "Maspin: the new frontier". Clin. Cancer Res. 12 (24): 7279–83. doi:10.1158/1078-0432.CCR-06-1589. PMID 17189399. 

Further reading

  • Sager R, Sheng S, Pemberton P, Hendrix MJ (1998). "Maspin. A tumor suppressing serpin.". Adv. Exp. Med. Biol. 425: 77–88. PMID 9433491. 
  • Sheng S (2006). "The promise and challenge toward the clinical application of maspin in cancer.". Front. Biosci. 9: 2733–45. doi:10.2741/1432. PMID 15353310. 
  • Lockett J, Yin S, Li X, et al. (2006). "Tumor suppressive maspin and epithelial homeostasis.". J. Cell. Biochem. 97 (4): 651–60. doi:10.1002/jcb.20721. PMID 16329135. 
  • Chen EI, Yates JR (2006). "Maspin and tumor metastasis.". IUBMB Life 58 (1): 25–9. doi:10.1080/15216540500531721. PMID 16540429. 
  • Khalkhali-Ellis Z (2007). "Maspin: the new frontier.". Clin. Cancer Res. 12 (24): 7279–83. doi:10.1158/1078-0432.CCR-06-1589. PMID 17189399. 
  • Schneider SS, Schick C, Fish KE, et al. (1995). "A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene.". Proc. Natl. Acad. Sci. U.S.A. 92 (8): 3147–51. doi:10.1073/pnas.92.8.3147. PMC 42122. PMID 7724531. 
  • Pemberton PA, Wong DT, Gibson HL, et al. (1995). "The tumor suppressor maspin does not undergo the stressed to relaxed transition or inhibit trypsin-like serine proteases. Evidence that maspin is not a protease inhibitory serpin.". J. Biol. Chem. 270 (26): 15832–7. doi:10.1074/jbc.270.26.15832. PMID 7797587. 
  • Zou Z, Anisowicz A, Hendrix MJ, et al. (1994). "Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells.". Science 263 (5146): 526–9. doi:10.1126/science.8290962. PMID 8290962. 
  • Pemberton PA, Tipton AR, Pavloff N, et al. (1998). "Maspin is an intracellular serpin that partitions into secretory vesicles and is present at the cell surface.". J. Histochem. Cytochem. 45 (12): 1697–706. PMID 9389773. 
  • Xia W, Lau YK, Hu MC, et al. (2000). "High tumoral maspin expression is associated with improved survival of patients with oral squamous cell carcinoma.". Oncogene 19 (20): 2398–403. doi:10.1038/sj.onc.1203535. PMID 10828881. 
  • Biliran H, Sheng S (2002). "Pleiotrophic inhibition of pericellular urokinase-type plasminogen activator system by endogenous tumor suppressive maspin.". Cancer Res. 61 (24): 8676–82. PMID 11751384. 
  • Blacque OE, Worrall DM (2002). "Evidence for a direct interaction between the tumor suppressor serpin, maspin, and types I and III collagen.". J. Biol. Chem. 277 (13): 10783–8. doi:10.1074/jbc.M110992200. PMID 11788595. 
  • Dokras A, Gardner LM, Kirschmann DA, et al. (2002). "The tumour suppressor gene maspin is differentially regulated in cytotrophoblasts during human placental development.". Placenta 23 (4): 274–80. doi:10.1053/plac.2001.0784. PMID 11969337. 
  • Jiang N, Meng Y, Zhang S, et al. (2002). "Maspin sensitizes breast carcinoma cells to induced apoptosis.". Oncogene 21 (26): 4089–98. doi:10.1038/sj.onc.1205507. PMID 12037665. 
  • Odero-Marah VA, Khalkhali-Ellis Z, Schneider GB, et al. (2002). "Tyrosine phosphorylation of maspin in normal mammary epithelia and breast cancer cells.". Biochem. Biophys. Res. Commun. 295 (4): 800–5. doi:10.1016/S0006-291X(02)00764-7. PMID 12127964. 
  • Maass N, Biallek M, Rösel F, et al. (2002). "Hypermethylation and histone deacetylation lead to silencing of the maspin gene in human breast cancer.". Biochem. Biophys. Res. Commun. 297 (1): 125–8. doi:10.1016/S0006-291X(02)02136-8. PMID 12220518. 
  • Sood AK, Fletcher MS, Gruman LM, et al. (2002). "The paradoxical expression of maspin in ovarian carcinoma.". Clin. Cancer Res. 8 (9): 2924–32. PMID 12231537. 
  • Son HJ, Sohn TS, Song SY, et al. (2003). "Maspin expression in human gastric adenocarcinoma.". Pathol. Int. 52 (8): 508–13. doi:10.1046/j.1440-1827.2002.01381.x. PMID 12366809. 
  • Bass R, Fernández AM, Ellis V (2003). "Maspin inhibits cell migration in the absence of protease inhibitory activity.". J. Biol. Chem. 277 (49): 46845–8. doi:10.1074/jbc.C200532200. PMID 12384513. 

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