SERPINB9

Serpin peptidase inhibitor, clade B (ovalbumin), member 9, also known as SERPINB9, is a human gene.cite web | title = Entrez Gene: SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5272| accessdate = ]

PBB_Summary
section_title =
summary_text = PI9 belongs to the large superfamily of serine proteinase inhibitors (serpins), which bind to and inactivate serine proteinases. These interactions are involved in many cellular processes, including coagulation, fibrinolysis, complement fixation, matrix remodeling, and apoptosis (Sprecher et al., 1995). [supplied by OMIM] cite web | title = Entrez Gene: SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5272| accessdate = ]

ee also

* Serpin

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Sprecher CA, Morgenstern KA, Mathewes S, "et al." |title=Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors. |journal=J. Biol. Chem. |volume=270 |issue= 50 |pages= 29854–61 |year= 1996 |pmid= 8530382 |doi=
*cite journal | author=Sun J, Bird CH, Sutton V, "et al." |title=A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes. |journal=J. Biol. Chem. |volume=271 |issue= 44 |pages= 27802–9 |year= 1996 |pmid= 8910377 |doi=
*cite journal | author=Sun J, Stephens R, Mirza G, "et al." |title=A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes. |journal=Cytogenet. Cell Genet. |volume=82 |issue= 3-4 |pages= 273–7 |year= 1999 |pmid= 9858835 |doi=
*cite journal | author=Annand RR, Dahlen JR, Sprecher CA, "et al." |title=Caspase-1 (interleukin-1beta-converting enzyme) is inhibited by the human serpin analogue proteinase inhibitor 9. |journal=Biochem. J. |volume=342 Pt 3 |issue= |pages= 655–65 |year= 1999 |pmid= 10477277 |doi=
*cite journal | author=Kanamori H, Krieg S, Mao C, "et al." |title=Proteinase inhibitor 9, an inhibitor of granzyme B-mediated apoptosis, is a primary estrogen-inducible gene in human liver cells. |journal=J. Biol. Chem. |volume=275 |issue= 8 |pages= 5867–73 |year= 2000 |pmid= 10681578 |doi=
*cite journal | author=Bladergroen BA, Strik MC, Bovenschen N, "et al." |title=The granzyme B inhibitor, protease inhibitor 9, is mainly expressed by dendritic cells and at immune-privileged sites. |journal=J. Immunol. |volume=166 |issue= 5 |pages= 3218–25 |year= 2001 |pmid= 11207275 |doi=
*cite journal | author=Buzza MS, Hirst CE, Bird CH, "et al." |title=The granzyme B inhibitor, PI-9, is present in endothelial and mesothelial cells, suggesting that it protects bystander cells during immune responses. |journal=Cell. Immunol. |volume=210 |issue= 1 |pages= 21–9 |year= 2001 |pmid= 11485349 |doi= 10.1006/cimm.2001.1806
*cite journal | author=Hirst CE, Buzza MS, Sutton VR, "et al." |title=Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction. |journal=Mol. Hum. Reprod. |volume=7 |issue= 12 |pages= 1133–42 |year= 2002 |pmid= 11719590 |doi=
*cite journal | author=Tanaka K, Harashima N, Niiya F, "et al." |title=Serine proteinase inhibitor 9 can be recognized by cytotoxic T lymphocytes of epithelial cancer patients. |journal=Jpn. J. Cancer Res. |volume=93 |issue= 2 |pages= 198–208 |year= 2002 |pmid= 11856484 |doi=
*cite journal | author=ten Berge RL, Meijer CJ, Dukers DF, "et al." |title=Expression levels of apoptosis-related proteins predict clinical outcome in anaplastic large cell lymphoma. |journal=Blood |volume=99 |issue= 12 |pages= 4540–6 |year= 2002 |pmid= 12036886 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hirst CE, Buzza MS, Bird CH, "et al." |title=The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency. |journal=J. Immunol. |volume=170 |issue= 2 |pages= 805–15 |year= 2003 |pmid= 12517944 |doi=
*cite journal | author=Rowshani AT, Florquin S, Bemelman F, "et al." |title=Hyperexpression of the granzyme B inhibitor PI-9 in human renal allografts: a potential mechanism for stable renal function in patients with subclinical rejection. |journal=Kidney Int. |volume=66 |issue= 4 |pages= 1417–22 |year= 2005 |pmid= 15458434 |doi= 10.1111/j.1523-1755.2004.00903.x
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Mahrus S, Kisiel W, Craik CS |title=Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B. |journal=J. Biol. Chem. |volume=279 |issue= 52 |pages= 54275–82 |year= 2005 |pmid= 15494398 |doi= 10.1074/jbc.M411482200
*cite journal | author=Classen CF, Ushmorov A, Bird P, Debatin KM |title=The granzyme B inhibitor PI-9 is differentially expressed in all main subtypes of pediatric acute lymphoblastic leukemias. |journal=Haematologica |volume=89 |issue= 11 |pages= 1314–21 |year= 2006 |pmid= 15531453 |doi=
*cite journal | author=Bruneel A, Labas V, Mailloux A, "et al." |title=Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. |journal=Proteomics |volume=5 |issue= 15 |pages= 3876–84 |year= 2006 |pmid= 16130169 |doi= 10.1002/pmic.200401239
*cite journal | author=van Houdt IS, Oudejans JJ, van den Eertwegh AJ, "et al." |title=Expression of the apoptosis inhibitor protease inhibitor 9 predicts clinical outcome in vaccinated patients with stage III and IV melanoma. |journal=Clin. Cancer Res. |volume=11 |issue= 17 |pages= 6400–7 |year= 2005 |pmid= 16144945 |doi= 10.1158/1078-0432.CCR-05-0306
*cite journal | author=Stelzl U, Worm U, Lalowski M, "et al." |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209

External links

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