SERPINB7

Serpin peptidase inhibitor, clade B (ovalbumin), member 7
Identifiers
Symbols	SERPINB7; DKFZp686D06190; MEGSIN; MGC120014; MGC120015
External IDs	OMIM: 603357 MGI: 2151053 HomoloGene: 68363 GeneCards: SERPINB7 Gene
Gene Ontology Molecular function • serine-type endopeptidase inhibitor activity • peptidase inhibitor activity Cellular component • cytoplasm Biological process • negative regulation of endopeptidase activity • regulation of proteolysis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8710	116872
Ensembl	ENSG00000166396	ENSMUSG00000067001
UniProt	O75635	Q6P3F8
RefSeq (mRNA)	NM_001040147.1	NM_027548.3
RefSeq (protein)	NP_001035237.1	NP_081824.1
Location (UCSC)	Chr 18: 61.42 – 61.47 Mb	Chr 1: 109.3 – 109.35 Mb
PubMed search	[1]	[2]

Serpin B7 is a protein that in humans is encoded by the SERPINB7 gene.^[1]

See also

• Serpin

References

1. ^ "Entrez Gene: SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8710. 

Further reading

• Tsujimoto M, Tsuruoka N, Ishida N, et al. (1997). "Purification, cDNA cloning, and characterization of a new serpin with megakaryocyte maturation activity.". J. Biol. Chem. 272 (24): 15373–80. doi:10.1074/jbc.272.24.15373. PMID 9182567. 
• Miyata T, Nangaku M, Suzuki D, et al. (1998). "A mesangium-predominant gene, megsin, is a new serpin upregulated in IgA nephropathy.". J. Clin. Invest. 102 (4): 828–36. doi:10.1172/JCI2450. PMC 508946. PMID 9710452. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=508946. 
• Inagi R, Miyata T, Suzuki D, et al. (2001). "Specific tissue distribution of megsin, a novel serpin, in the glomerulus and its up-regulation in IgA nephropathy.". Biochem. Biophys. Res. Commun. 286 (5): 1098–106. doi:10.1006/bbrc.2001.5509. PMID 11527413. 
• Inagi R, Miyata T, Imasawa T, et al. (2003). "Mesangial cell-predominant gene, megsin.". Nephrol. Dial. Transplant. 17 Suppl 9: 32–3. PMID 12386281. 
• Inagi R, Miyata T, Nangaku M, et al. (2003). "Transcriptional regulation of a mesangium-predominant gene, megsin.". J. Am. Soc. Nephrol. 13 (11): 2715–22. doi:10.1097/01.ASN.0000033507.32175.FA. PMID 12397041. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Li YJ, Du Y, Li CX, et al. (2004). "Family-based association study showing that immunoglobulin A nephropathy is associated with the polymorphisms 2093C and 2180T in the 3' untranslated region of the Megsin gene.". J. Am. Soc. Nephrol. 15 (7): 1739–43. doi:10.1097/01.ASN.0000130858.00688.46. PMID 15213261. 
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=515316. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Inagi R, Nangaku M, Usuda N, et al. (2005). "Novel serpinopathy in rat kidney and pancreas induced by overexpression of megsin.". J. Am. Soc. Nephrol. 16 (5): 1339–49. doi:10.1681/ASN.2004070600. PMID 15788472. 
• Xia Y, Li Y, Du Y, et al. (2006). "Association of MEGSIN 2093C-2180T haplotype at the 3' untranslated region with disease severity and progression of IgA nephropathy.". Nephrol. Dial. Transplant. 21 (6): 1570–4. doi:10.1093/ndt/gfk096. PMID 16431886. 
• Xia YF, Huang S, Li X, et al. (2006). "A family-based association study of megsin A23167G polymorphism with susceptibility and progression of IgA nephropathy in a Chinese population.". Clin. Nephrol. 65 (3): 153–9. PMID 16550745. 

External links

• The MEROPS online database for peptidases and their inhibitors: I04.012
• MeSH SERPINB7+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.